(Q64119068)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30595456%20AND%20SRC:MED&resulttype=core&format=json

16 April 2020

title

How Structural Biologists and the Protein Data Bank Contributed to Recent FDA New Drug Approvals (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30595456%20AND%20SRC:MED&resulttype=core&format=json

16 April 2020

1

John D Westbrook

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30595456%20AND%20SRC:MED&resulttype=core&format=json

16 April 2020

author name string

Stephen K Burley

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30595456%20AND%20SRC:MED&resulttype=core&format=json

16 April 2020

language of work or name

English

0 references

publication date

27 December 2018

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30595456%20AND%20SRC:MED&resulttype=core&format=json

16 April 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30595456%20AND%20SRC:MED&resulttype=core&format=json

16 April 2020

volume

27

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30595456%20AND%20SRC:MED&resulttype=core&format=json

16 April 2020

issue

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30595456%20AND%20SRC:MED&resulttype=core&format=json

16 April 2020

page(s)

211-217

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30595456%20AND%20SRC:MED&resulttype=core&format=json

Structure of prealbumin: secondary, tertiary and quaternary interactions determined by Fourier refinement at 1.8 A

16 April 2020

cites work

1 reference

12 December 2020

Structure of the human class I histocompatibility antigen, HLA-A2

1 reference

12 December 2020

Atomic Positions in Rhombohedral 2-Zinc Insulin Crystals

1 reference

12 December 2020

Peptide inhibitors of src SH3-SH2-phosphoprotein interactions

1 reference

12 December 2020

Crystal structure of the obese protein leptin-E100

1 reference

12 December 2020

Inhibitors of HIV-1 protease: a major success of structure-assisted drug design

1 reference

12 December 2020

The Protein Data Bank

1 reference

12 December 2020

The structure of the N-terminal actin-binding domain of human dystrophin and how mutations in this domain may cause Duchenne or Becker muscular dystrophy

1 reference

12 December 2020

Glivec (STI571, imatinib), a rationally developed, targeted anticancer drug

1 reference

12 December 2020

Crystal structures of the kinase domain of c-Abl in complex with the small molecule inhibitors PD173955 and imatinib (STI-571)

1 reference

12 December 2020

Structure of the extracellular region of HER2 alone and in complex with the Herceptin Fab

1 reference

12 December 2020

X-ray structure of human acid-β-glucosidase, the defective enzyme in Gaucher disease

1 reference

12 December 2020

Announcing the worldwide Protein Data Bank

1 reference

12 December 2020

Structural and functional analysis of the costimulatory receptor programmed death-1.

1 reference

12 December 2020

Insights into ErbB signaling from the structure of the ErbB2-pertuzumab complex

1 reference

12 December 2020

1 reference

12 December 2020

Contributions to the NIH-NIGMS Protein Structure Initiative from the PSI Production Centers.

1 reference

12 December 2020

The PD-1/PD-L1 complex resembles the antigen-binding Fv domains of antibodies and T cell receptors

1 reference

12 December 2020

Molecular recognition of parathyroid hormone by its G protein-coupled receptor

1 reference

12 December 2020

Crystal structure of the complex between programmed death-1 (PD-1) and its ligand PD-L2

1 reference

12 December 2020

PDBe: Protein Data Bank in Europe

1 reference

12 December 2020

Escape from lysosomes

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12 December 2020

Clinical efficacy of a RAF inhibitor needs broad target blockade in BRAF-mutant melanoma

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12 December 2020

Utility of protein structures in overcoming ADMET-related issues of drug-like compounds

1 reference

12 December 2020

Structural basis for dimethylarginine recognition by the Tudor domains of human SMN and SPF30 proteins

1 reference

12 December 2020

Leveraging SBDD in protein therapeutic development: antibody engineering.

1 reference

12 December 2020

Maximizing human epidermal growth factor receptor 2 inhibition: a new oncologic paradigm in the era of targeted therapy.

1 reference

12 December 2020

The role of structural information in the discovery of direct thrombin and factor Xa inhibitors

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12 December 2020

Ligand-controlled assembly of hexamers, dihexamers, and linear multihexamer structures by the engineered acylated insulin degludec

1 reference

12 December 2020

A specific antidote for dabigatran: functional and structural characterization

1 reference

12 December 2020

AG10 inhibits amyloidogenesis and cellular toxicity of the familial amyloid cardiomyopathy-associated V122I transthyretin

1 reference

12 December 2020

Structure of full-length human anti-PD1 therapeutic IgG4 antibody pembrolizumab

1 reference

12 December 2020

2015 FDA drug approvals

1 reference

12 December 2020

Innovation in the pharmaceutical industry: New estimates of R&D costs

1 reference

12 December 2020

The FAIR Guiding Principles for scientific data management and stewardship

1 reference

12 December 2020

Structural basis for blocking PD-1-mediated immune suppression by therapeutic antibody pembrolizumab

1 reference

12 December 2020

D3R grand challenge 2015: Evaluation of protein-ligand pose and affinity predictions

1 reference

12 December 2020

Protein Data Bank Japan (PDBj): updated user interfaces, resource description framework, analysis tools for large structures

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12 December 2020

Structural basis of checkpoint blockade by monoclonal antibodies in cancer immunotherapy

1 reference

12 December 2020

OneDep: Unified wwPDB System for Deposition, Biocuration, and Validation of Macromolecular Structures in the PDB Archive

1 reference

12 December 2020

Landscape of Innovation for Cardiovascular Pharmaceuticals: From Basic Science to New Molecular Entities

1 reference

12 December 2020

The impact of structural biology in medicine illustrated with four case studies

1 reference

12 December 2020

Opportunities and challenges in phenotypic drug discovery: an industry perspective

1 reference

12 December 2020

Protein crystallography and drug discovery: recollections of knowledge exchange between academia and industry

1 reference

12 December 2020

RCSB Protein Data Bank: Sustaining a living digital data resource that enables breakthroughs in scientific research and biomedical education

1 reference

12 December 2020

Validation of Structures in the Protein Data Bank

1 reference

12 December 2020

Contribution of NIH funding to new drug approvals 2010-2016.

1 reference

12 December 2020

Worldwide Protein Data Bank biocuration supporting open access to high-quality 3D structural biology data

1 reference

12 December 2020

Cryo-EM in drug discovery: achievements, limitations and prospects

1 reference

12 December 2020