(Q64218188)

English

Amythiamicin D and Related Thiopeptides as Inhibitors of the Bacterial Elongation Factor EF-Tu: Modification of the Amino Acid at Carbon Atom C2 of Ring C Dramatically Influences Activity

scientific article published on 17 September 2013

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scholarly article

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27 February 2020

Amythiamicin D and related thiopeptides as inhibitors of the bacterial elongation factor EF-Tu: modification of the amino acid at carbon atom C2 of ring C dramatically influences activity (English)

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27 February 2020

Daniel N. Wilson

7

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27 February 2020

8

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27 February 2020

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Stefan Gross

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27 February 2020

Fabian Nguyen

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27 February 2020

Matthias Bierschenk

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27 February 2020

Daniel Sohmen

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27 February 2020

Thomas Menzel

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27 February 2020

Iris Antes

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27 February 2020

publication date

17 September 2013

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27 February 2020

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27 February 2020

8

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27 February 2020

12

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27 February 2020

1954-1962

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27 February 2020

Separation of three microbial amino acid polymerization factors

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300323

7 January 2021

based on heuristic

inferred from DOI database lookup

Mechanisms of EF-Tu, a pioneer GTPase

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300323

7 January 2021

based on heuristic

inferred from DOI database lookup

Crystal structure of active elongation factor Tu reveals major domain rearrangements

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300323

7 January 2021

based on heuristic

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Elongation factor Tu-targeted antibiotics: four different structures, two mechanisms of action

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300323

7 January 2021

based on heuristic

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Structure of an EF-Tu complex with a thiazolyl peptide antibiotic determined at 2.35 A resolution: atomic basis for GE2270A inhibition of EF-Tu

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300323

7 January 2021

based on heuristic

inferred from DOI database lookup

Structural Basis of the Action of Pulvomycin and GE2270 A on Elongation Factor Tu†,‡

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300323

7 January 2021

based on heuristic

inferred from DOI database lookup

Enacyloxin IIa pinpoints a binding pocket of elongation factor Tu for development of novel antibiotics

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300323

7 January 2021

based on heuristic

inferred from DOI database lookup

Conformational change of elongation factor Tu (EF-Tu) induced by antibiotic binding. Crystal structure of the complex between EF-Tu.GDP and aurodox

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300323

7 January 2021

based on heuristic

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Antibiotic GE2270 a: a novel inhibitor of bacterial protein synthesis. I. Isolation and characterization

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300323

7 January 2021

based on heuristic

inferred from DOI database lookup

Antibiotic GE2270 a: a novel inhibitor of bacterial protein synthesis. II. Structure elucidation

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300323

7 January 2021

based on heuristic

inferred from DOI database lookup

Components of the GE2270 Complex Produced by Planobispora rosea ATCC 53773

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300323

7 January 2021

based on heuristic

inferred from DOI database lookup

Targeted screening for elongation factor Tu binding antibiotics

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300323

7 January 2021

based on heuristic

inferred from DOI database lookup

Combinatorial modification of natural products: synthesis and in vitro analysis of derivatives of thiazole peptide antibiotic GE2270 A: A-ring modifications

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300323

7 January 2021

based on heuristic

inferred from DOI database lookup

4-Aminothiazolyl analogues of GE2270 A: antibacterial lead finding.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300323

7 January 2021

based on heuristic

inferred from DOI database lookup

In vitro and in vivo activities of novel, semisynthetic thiopeptide inhibitors of bacterial elongation factor Tu.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300323

7 January 2021

based on heuristic

inferred from DOI database lookup

Antibacterial optimization of 4-aminothiazolyl analogues of the natural product GE2270 A: identification of the cycloalkylcarboxylic acids

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300323

7 January 2021

based on heuristic

inferred from DOI database lookup

Discovery of LFF571: an investigational agent for Clostridium difficile infection

1 reference

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7 January 2021

based on heuristic

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Antimicrobial activities of chemically modified thiazolyl peptide antibiotic MDL 62,879 (GE2270A).

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300323

7 January 2021

based on heuristic

inferred from DOI database lookup

Thiopeptide antibiotics

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300323

7 January 2021

based on heuristic

inferred from DOI database lookup

From amino acids to heteroaromatics--thiopeptide antibiotics, nature's heterocyclic peptides

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300323

7 January 2021

based on heuristic

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Novel antibiotics, amythiamicins. I. Taxonomy, fermentation, isolation, physico-chemical properties, and antimicrobial activity.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300323

7 January 2021

based on heuristic

inferred from DOI database lookup

Novel antibiotics, amythiamicins. II. Structure elucidation of amythiamicin D

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300323

7 January 2021

based on heuristic

inferred from DOI database lookup

Novel antibiotics, amythiamicins. III. Structure elucidations of amythiamicins A, B and C

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300323

7 January 2021

based on heuristic

inferred from DOI database lookup

Novel antibiotics, amythiamicins. IV. A mutation in the elongation factor Tu gene in a resistant mutant of B. subtilis

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300323

7 January 2021

based on heuristic

inferred from DOI database lookup

Total synthesis of thiostrepton. Retrosynthetic analysis and construction of key building blocks

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300323

7 January 2021

based on heuristic

inferred from DOI database lookup

Total synthesis of thiostrepton. Assembly of key building blocks and completion of the synthesis

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300323

7 January 2021

based on heuristic

inferred from DOI database lookup

Total synthesis of the thiopeptide antibiotic amythiamicin D.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300323

7 January 2021

based on heuristic

inferred from DOI database lookup

Total synthesis of antibiotics GE2270A and GE2270T.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300323

7 January 2021

based on heuristic

inferred from DOI database lookup

Total synthesis of thiopeptide antibiotics GE2270A, GE2270T, and GE2270C1.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300323

7 January 2021

based on heuristic

inferred from DOI database lookup

Total synthesis of siomycin A: construction of synthetic segments.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300323

7 January 2021

based on heuristic

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Total synthesis and stereochemical assignment of micrococcin P1.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300323

7 January 2021

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Micrococcin P1: structure, biology and synthesis

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300323

7 January 2021

based on heuristic

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Total synthesis and complete structural assignment of thiocillin I.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300323

7 January 2021

based on heuristic

inferred from DOI database lookup

How thiostrepton was made in the laboratory

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300323

7 January 2021

based on heuristic

inferred from DOI database lookup

Total Synthesis of the Thiazolyl Peptide GE2270 A

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300323

7 January 2021

based on heuristic

inferred from DOI database lookup

Concise total synthesis of the thiazolyl peptide antibiotic GE2270 A.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300323

7 January 2021

based on heuristic

inferred from DOI database lookup

Total syntheses of the thiopeptides amythiamicin C and D.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300323

7 January 2021

based on heuristic

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N-tert-Butanesulfinyl Imines: Versatile Intermediates for the Asymmetric Synthesis of Amines

1 reference

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Nuclear magnetic resonance enantiomer regents. Configurational correlations via nuclear magnetic resonance chemical shifts of diastereomeric mandelate, O-methylmandelate, and .alpha.-methoxy-.alpha.-trifluoromethylphenylacetate (MTPA) esters

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7 January 2021

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Mosher ester analysis for the determination of absolute configuration of stereogenic (chiral) carbinol carbons

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300323

7 January 2021

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PyBOP® and PyBroP: Two reagents for the difficult coupling of the α,α-dialkyl amino acid, Aib

1 reference

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7 January 2021

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Palladium-catalyzed coupling of tetraorganotin compounds with aryl and benzyl halides. Synthetic utility and mechanism

1 reference

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7 January 2021

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The Palladium-Catalyzed Cross-Coupling Reactions of Organotin Reagents with Organic Electrophiles[New Synthetic Methods(58)]

1 reference

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7 January 2021

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Synthesis of 2'-substituted 4-bromo-2,4'-bithiazoles by regioselective cross-coupling reactions

1 reference

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7 January 2021

based on heuristic

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Synthesis of the Heterocyclic Core of the GE 2270 Antibiotics and Structure Elucidation of a Major Degradation Product

1 reference

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7 January 2021

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Mechanism of inhibition of translocation by kanamycin and viomycin: A comparative study with fusidic acid

1 reference

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7 January 2021

based on heuristic

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Over-expression of target genes as a mechanism of antibiotic resistance in bacteria.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300323

7 January 2021

based on heuristic

inferred from DOI database lookup

GE2270A-resistant mutations in elongation factor Tu allow productive aminoacyl-tRNA binding to EF-Tu.GTP.GE2270A complexes.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300323

7 January 2021

based on heuristic

inferred from DOI database lookup

Crystal structure of the ternary complex of Phe-tRNAPhe, EF-Tu, and a GTP analog

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300323

7 January 2021

based on heuristic

inferred from DOI database lookup

Solution structures of thiopeptide antibiotics

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300323

7 January 2021

based on heuristic

inferred from DOI database lookup

DynaDock: A new molecular dynamics-based algorithm for protein-peptide docking including receptor flexibility.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300323

7 January 2021

based on heuristic

inferred from DOI database lookup

Rugulactone and its analogues exert antibacterial effects through multiple mechanisms including inhibition of thiamine biosynthesis

1 reference

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7 January 2021

based on heuristic

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Identification of distinct thiopeptide-antibiotic precursor lead compounds using translation machinery assays

1 reference

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7 January 2021

based on heuristic

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1 reference

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Identifiers

10.1002/CMDC.201300323

1 reference

Europe PubMed Central

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27 February 2020

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

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27 February 2020

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