(Q64286968)

English

DNA damage repair alterations modulate M2 polarization of microglia to remodel the tumor microenvironment via the p53-mediated MDK expression in glioma

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scholarly article

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DNA damage repair alterations modulate M2 polarization of microglia to remodel the tumor microenvironment via the p53-mediated MDK expression in glioma (English)

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author name string

Xiangqi Meng

1

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Chunbin Duan

2

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Hengyuan Pang

3

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Qun Chen

4

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Bo Han

5

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Caijun Zha

6

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Magafurov Dinislam

7

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Pengfei Wu

8

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Ziwei Li

9

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Shihong Zhao

10

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Ruijia Wang

11

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Lin Lin

12

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Chuanlu Jiang

13

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Jinquan Cai

14

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language of work or name

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publication date

March 2019

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41

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185-199

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Establishment of human microglial cell lines after transfection of primary cultures of embryonic microglial cells with the SV40 large T antigen

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https://pubmed.ncbi.nlm.nih.gov/30773478

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Promoter hypermethylation and BRCA1 inactivation in sporadic breast and ovarian tumors

1 reference

https://pubmed.ncbi.nlm.nih.gov/30773478

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Surfing the p53 network

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https://pubmed.ncbi.nlm.nih.gov/30773478

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Vascular endothelial growth factor receptors in the regulation of angiogenesis and lymphangiogenesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/30773478

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Midkine is involved in neutrophil infiltration into the tubulointerstitium in ischemic renal injury

1 reference

https://pubmed.ncbi.nlm.nih.gov/30773478

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Live or let die: the cell's response to p53

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https://pubmed.ncbi.nlm.nih.gov/30773478

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

VEGF inhibits T-cell development and may contribute to tumor-induced immune suppression.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30773478

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Fully automated assessment of inflammatory cell counts and cytokine expression in bronchial tissue

1 reference

https://pubmed.ncbi.nlm.nih.gov/30773478

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Immune regulation by helminth parasites: cellular and molecular mechanisms

1 reference

https://pubmed.ncbi.nlm.nih.gov/30773478

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cytoscape: a software environment for integrated models of biomolecular interaction networks

1 reference

https://pubmed.ncbi.nlm.nih.gov/30773478

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The dark side of C5a in sepsis

1 reference

https://pubmed.ncbi.nlm.nih.gov/30773478

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

DNA damage induced by temozolomide signals to both ATM and ATR: role of the mismatch repair system

1 reference

https://pubmed.ncbi.nlm.nih.gov/30773478

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Truncated midkine induces transformation of cultured cells and short latency of tumorigenesis in nude mice.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30773478

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Lack of PTEN sequesters CHK1 and initiates genetic instability.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30773478

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Targets of microRNA regulation in the Drosophila oocyte proteome

1 reference

https://pubmed.ncbi.nlm.nih.gov/30773478

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

microRNA target predictions across seven Drosophila species and comparison to mammalian targets

1 reference

https://pubmed.ncbi.nlm.nih.gov/30773478

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles

1 reference

https://pubmed.ncbi.nlm.nih.gov/30773478

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

DNA damage: a trigger of innate immunity but a requirement for adaptive immune homeostasis

1 reference

https://pubmed.ncbi.nlm.nih.gov/30773478

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Global analysis of microRNA target gene expression reveals that miRNA targets are lower expressed in mature mouse and Drosophila tissues than in the embryos

1 reference

https://pubmed.ncbi.nlm.nih.gov/30773478

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

PPARγ Activation Primes Human Monocytes into Alternative M2 Macrophages with Anti-inflammatory Properties

1 reference

https://pubmed.ncbi.nlm.nih.gov/30773478

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The pivotal role of VEGF on glomerular macrophage infiltration in advanced diabetic nephropathy.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30773478

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Promotion of glioma cell survival by acyl-CoA synthetase 5 under extracellular acidosis conditions.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30773478

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Chromatin signature reveals over a thousand highly conserved large non-coding RNAs in mammals

1 reference

https://pubmed.ncbi.nlm.nih.gov/30773478

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Association of TNFSF4 (OX40L) polymorphisms with susceptibility to systemic sclerosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/30773478

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1

1 reference

https://pubmed.ncbi.nlm.nih.gov/30773478

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

MGMT promoter methylation in malignant gliomas: ready for personalized medicine?

1 reference

https://pubmed.ncbi.nlm.nih.gov/30773478

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

NOX4 expression in human microglia leads to constitutive generation of reactive oxygen species and to constitutive IL-6 expression.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30773478

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The angiogenic growth factor and biomarker midkine is a tumor-shared antigen

1 reference

https://pubmed.ncbi.nlm.nih.gov/30773478

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Loss of ATM/Chk2/p53 pathway components accelerates tumor development and contributes to radiation resistance in gliomas

1 reference

https://pubmed.ncbi.nlm.nih.gov/30773478

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Epigenetic changes of DNA repair genes in cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/30773478

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular signatures database (MSigDB) 3.0.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30773478

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cytokine release from innate immune cells: association with diverse membrane trafficking pathways

1 reference

https://pubmed.ncbi.nlm.nih.gov/30773478

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Isocitrate dehydrogenase mutations in gliomas: mechanisms, biomarkers and therapeutic target

1 reference

https://pubmed.ncbi.nlm.nih.gov/30773478

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Links between mutant p53 and genomic instability

1 reference

https://pubmed.ncbi.nlm.nih.gov/30773478

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Microglial cell origin and phenotypes in health and disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/30773478

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Integrative Genomics Viewer (IGV): high-performance genomics data visualization and exploration

1 reference

https://pubmed.ncbi.nlm.nih.gov/30773478

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

miR-181d: a predictive glioblastoma biomarker that downregulates MGMT expression

1 reference

https://pubmed.ncbi.nlm.nih.gov/30773478

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prognostically relevant gene signatures of high-grade serous ovarian carcinoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/30773478

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In human glioblastomas transcript elongation by alternative polyadenylation and miRNA targeting is a potent mechanism of MGMT silencing

1 reference

https://pubmed.ncbi.nlm.nih.gov/30773478

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

International Union of Basic and Clinical Pharmacology. [corrected]. LXXXVII. Complement peptide C5a, C4a, and C3a receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/30773478

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dual effect of serum amyloid A on the invasiveness of glioma cells.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30773478

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

M2 microglia and macrophages drive oligodendrocyte differentiation during CNS remyelination

1 reference

https://pubmed.ncbi.nlm.nih.gov/30773478

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Distinguishing score 0 from score 1+ in HER2 immunohistochemistry-negative breast cancer: clinical and pathobiological relevance.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30773478

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The somatic genomic landscape of glioblastoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/30773478

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Gene reporter assay to validate microRNA targets in Drosophila S2 cells.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30773478

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

DNA damage response genes and the development of cancer metastasis

1 reference

https://pubmed.ncbi.nlm.nih.gov/30773478

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Immune heterogeneity of glioblastoma subtypes: extrapolation from the cancer genome atlas

1 reference

https://pubmed.ncbi.nlm.nih.gov/30773478

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The M1 and M2 paradigm of macrophage activation: time for reassessment

1 reference

https://pubmed.ncbi.nlm.nih.gov/30773478

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Durable therapeutic efficacy utilizing combinatorial blockade against IDO, CTLA-4, and PD-L1 in mice with brain tumors.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30773478

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Multiple targets of the microRNA miR-8 contribute to immune homeostasis in Drosophila.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30773478

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Microglia and brain macrophages in the molecular age: from origin to neuropsychiatric disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/30773478

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Importance of EGFR/ERCC1 interaction following radiation-induced DNA damage

1 reference

https://pubmed.ncbi.nlm.nih.gov/30773478

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

MGMT testing--the challenges for biomarker-based glioma treatment

1 reference

https://pubmed.ncbi.nlm.nih.gov/30773478

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cancer-specific defects in DNA repair pathways as targets for personalized therapeutic approaches

1 reference

https://pubmed.ncbi.nlm.nih.gov/30773478

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mutant IDH1-driven cellular transformation increases RAD51-mediated homologous recombination and temozolomide resistance

1 reference

https://pubmed.ncbi.nlm.nih.gov/30773478

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

HIV-1 Tat C modulates NOX2 and NOX4 expressions through miR-17 in a human microglial cell line

1 reference

https://pubmed.ncbi.nlm.nih.gov/30773478

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

An ambulance for retinol

1 reference

https://pubmed.ncbi.nlm.nih.gov/30773478

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Transcriptional factor specificity protein 1 (SP1) promotes the proliferation of glioma cells by up-regulating midkine (MDK).

1 reference

https://pubmed.ncbi.nlm.nih.gov/30773478

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Robust enumeration of cell subsets from tissue expression profiles

1 reference

https://pubmed.ncbi.nlm.nih.gov/30773478

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The DNA damage/repair cascade in glioblastoma cell lines after chemotherapeutic agent treatment

1 reference

https://pubmed.ncbi.nlm.nih.gov/30773478

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glioma Groups Based on 1p/19q, IDH, and TERT Promoter Mutations in Tumors

1 reference

https://pubmed.ncbi.nlm.nih.gov/30773478

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Diversity and plasticity of microglial cells in psychiatric and neurological disorders

1 reference

https://pubmed.ncbi.nlm.nih.gov/30773478

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Chemical proteomics reveals a γH2AX-53BP1 interaction in the DNA damage response

1 reference

https://pubmed.ncbi.nlm.nih.gov/30773478

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The Molecular Signatures Database (MSigDB) hallmark gene set collection

1 reference

https://pubmed.ncbi.nlm.nih.gov/30773478

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Vaccination with Irradiated Autologous Tumor Cells Mixed with Irradiated GM-K562 Cells Stimulates Antitumor Immunity and T Lymphocyte Activation in Patients with Recurrent Malignant Glioma

1 reference

https://pubmed.ncbi.nlm.nih.gov/30773478

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

ATRX loss promotes tumor growth and impairs nonhomologous end joining DNA repair in glioma

1 reference

https://pubmed.ncbi.nlm.nih.gov/30773478

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Classification based on mutations of TERT promoter and IDH characterizes subtypes in grade II/III gliomas

1 reference

https://pubmed.ncbi.nlm.nih.gov/30773478

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Genomic landscape of DNA repair genes in cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/30773478

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

IDH mutations in cancer and progress toward development of targeted therapeutics

1 reference

https://pubmed.ncbi.nlm.nih.gov/30773478

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

ATRX mutations and glioblastoma: Impaired DNA damage repair, alternative lengthening of telomeres, and genetic instability.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30773478

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Macrophage reaction against biomaterials in the mouse model - Phenotypes, functions and markers.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30773478

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mutant IDH1 Downregulates ATM and Alters DNA Repair and Sensitivity to DNA Damage Independent of TET2.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30773478

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Deletion of interleukin-6 in monocytes/macrophages suppresses the initiation of hepatocellular carcinoma in mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/30773478

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alternatively Activated (M2) Macrophage Phenotype Is Inducible by Endothelin-1 in Cultured Human Macrophages

1 reference

https://pubmed.ncbi.nlm.nih.gov/30773478

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Signal Peptide Peptidase, Encoded by HM13, Contributes to Tumor Progression by Affecting EGFRvIII Secretion Profiles in Glioblastoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/30773478

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Drugging the Cancers Addicted to DNA Repair

1 reference

https://pubmed.ncbi.nlm.nih.gov/30773478

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

DNA Damage and Repair Biomarkers of Immunotherapy Response

1 reference

https://pubmed.ncbi.nlm.nih.gov/30773478

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tumor Purity As an Underlying Key Factor in Glioma

1 reference

https://pubmed.ncbi.nlm.nih.gov/30773478

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mutational Landscapes of Smoking-Related Cancers in Caucasians and African Americans: Precision Oncology Perspectives at Wake Forest Baptist Comprehensive Cancer Center

1 reference

https://pubmed.ncbi.nlm.nih.gov/30773478

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Targeting glioma stem cells through combined BMI1 and EZH2 inhibition.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30773478

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Endogenous pleiotrophin and midkine regulate LPS-induced glial responses.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30773478

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Long Noncoding RNA NEAT1, Regulated by the EGFR Pathway, Contributes to Glioblastoma Progression Through the WNT/β-Catenin Pathway by Scaffolding EZH2.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30773478

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Microglia and macrophages in brain homeostasis and disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/30773478

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

LncRNA lnc-RI regulates homologous recombination repair of DNA double-strand breaks by stabilizing RAD51 mRNA as a competitive endogenous RNA.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30773478

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Loss of ATRX suppresses ATM dependent DNA damage repair by modulating H3K9me3 to enhance temozolomide sensitivity in glioma.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30773478

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mutant p53 cancers reprogram macrophages to tumor supporting macrophages via exosomal miR-1246.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30773478

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Genomic and Molecular Landscape of DNA Damage Repair Deficiency across The Cancer Genome Atlas.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30773478

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The Immune Landscape of Cancer.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30773478

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Temozolomide for Immunomodulation in the Treatment of Glioblastoma.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30773478

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Comprehensive Profiling of DNA Repair Defects in Breast Cancer Identifies a Novel Class of Endocrine Therapy Resistance Drivers

1 reference

https://pubmed.ncbi.nlm.nih.gov/30773478

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mesenchymal glioblastoma constitutes a major ceRNA signature in the TGF-β pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/30773478

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1016/J.EBIOM.2019.01.067

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