(Q64360391)

English

Safety, tolerability, pharmacokinetics, and immunogenicity of the therapeutic monoclonal antibody mAb114 targeting Ebola virus glycoprotein (VRC 608): an open-label phase 1 study

article by Martin R Gaudinski et al published 2 March 2019 in The Lancet

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Safety, tolerability, pharmacokinetics, and immunogenicity of the therapeutic monoclonal antibody mAb114 targeting Ebola virus glycoprotein (VRC 608): an open-label phase 1 study (English)

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Orthoebolavirus zairense

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pharmacokinetics

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Barney S. Graham

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Barney S Graham

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Julie Ledgerwood

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Julie E Ledgerwood

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Adrian B. McDermott

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Adrian McDermott

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John R. Mascola

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John R Mascola

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Ingelise J Gordon

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Ingelise J Gordon

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Richard A Koup

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Alicia T. Widge

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Alicia Widge

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Nancy J Sullivan

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LaSonji A. Holman

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LaSonji A Holman

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Martha Nason

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Martin R Gaudinski

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Martin R Gaudinski

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Laura Novik

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Nina M. Berkowitz

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Nina Berkowitz

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Galina V Yamshchikov

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Galina Yamshchikov

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John Misasi

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Charla A Andrews

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Charla Andrews

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Edmund Capparelli

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Edmund Capparelli

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Katherine V Houser

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Katherine V Houser

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Sandra Sitar

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Carolyn Laurencot

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Carolyn Laurencot

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Emily E Coates

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Cristina A Carter

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Cristina Carter

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Kevin Carlton

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Eugeania Burch

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Grace L Chen

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Sandra Vazquez

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Frank Arnold

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Heather Lawlor

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Jason Gall

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Robert T Bailer

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publication date

2 March 2019

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393

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10174

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889-898

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Virus nomenclature below the species level: a standardized nomenclature for natural variants of viruses assigned to the family Filoviridae

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An outbreak of Ebola in Uganda

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Assessment of the risk of Ebola virus transmission from bodily fluids and fomites

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Treatment of Ebola hemorrhagic fever with blood transfusions from convalescent patients. International Scientific and Technical Committee

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Evaluation of convalescent whole blood for treating Ebola Virus Disease in Freetown, Sierra Leone.

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Postexposure antibody prophylaxis protects nonhuman primates from filovirus disease.

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CD8+ cellular immunity mediates rAd5 vaccine protection against Ebola virus infection of nonhuman primates

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Reversion of advanced Ebola virus disease in nonhuman primates with ZMapp

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Mice with megabase humanization of their immunoglobulin genes generate antibodies as efficiently as normal mice

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Safety, pharmacokinetics, and immunogenicity of a co-formulated cocktail of three human monoclonal antibodies targeting Ebola virus glycoprotein in healthy adults: a randomised, first-in-human phase 1 study

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A Randomized, Controlled Trial of ZMapp for Ebola Virus Infection

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Structural and molecular basis for Ebola virus neutralization by protective human antibodies

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Filoviruses require endosomal cysteine proteases for entry but exhibit distinct protease preferences

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Experimental infection of cynomolgus macaques with Ebola-Reston filoviruses from the 1989-1990 U.S. epizootic

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https://pubmed.ncbi.nlm.nih.gov/30686586

12 December 2020

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10.1016/S0140-6736(19)30036-4

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