(Q67744025)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:1735694%20AND%20SRC:MED&resulttype=core&format=json

17 September 2019

title

Dual function nitroimidazoles less toxic than RSU 1069: selection of candidate drugs for clinical trial (RB 6145 and/or PD 130908 (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:1735694%20AND%20SRC:MED&resulttype=core&format=json

17 September 2019

Dual function nitroimidazoles less toxic than RSU 1069: selection of candidate drugs for clinical trial (RB 6145 and/or PD 130908) (English)

1 reference

https://api.crossref.org/works/10.1016/0360-3016(92)90872-F

12 November 2022

1 reference

https://api.crossref.org/works/10.1016/0360-3016(92)90872-F

12 November 2022

2

I. J. Stratford

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A1735694

12 November 2022

author name string

S. Cole

1

1 reference

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12 November 2022

E. M. Fielden

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A1735694

12 November 2022

G. E. Adams

4

1 reference

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12 November 2022

W. Leopold

5

1 reference

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12 November 2022

W. Elliott

6

1 reference

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12 November 2022

M. Suto

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A1735694

12 November 2022

J. Sebolt-Leopold

8

1 reference

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12 November 2022

language of work or name

English

0 references

publication date

1 January 1992

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:1735694%20AND%20SRC:MED&resulttype=core&format=json

full work available at URL

17 September 2019

https://api.elsevier.com/content/article/PII:036030169290872F?httpAccept=text/xml

1 reference

https://api.crossref.org/works/10.1016/0360-3016(92)90872-F

https://api.elsevier.com/content/article/PII:036030169290872F?httpAccept=text/plain

12 November 2022

1 reference

https://api.crossref.org/works/10.1016/0360-3016(92)90872-F

International Journal of Radiation Oncology Biology Physics

12 November 2022

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:1735694%20AND%20SRC:MED&resulttype=core&format=json

17 September 2019

volume

22

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:1735694%20AND%20SRC:MED&resulttype=core&format=json

17 September 2019

page(s)

545-548

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:1735694%20AND%20SRC:MED&resulttype=core&format=json

17 September 2019

issue

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:1735694%20AND%20SRC:MED&resulttype=core&format=json

Electron-affinic sensitization. VII. A correlation between structures, one-electron reduction potentials, and efficiencies of nitroimidazoles as hypoxic cell radiosensitizers

17 September 2019

cites work

1

1 reference

https://api.crossref.org/works/10.1016/0360-3016(92)90872-F

Radiation sensitization and chemopotentiation: RSU 1069, a compound more efficient than misonidazole in vitro and in vivo

12 November 2022

2

1 reference

https://api.crossref.org/works/10.1016/0360-3016(92)90872-F

RSU 1069, a 2-nitroimidazole containing an alkylating group: high efficiency as a radio- and chemosensitizer in vitro and in vivo

12 November 2022

3

1 reference

https://api.crossref.org/works/10.1016/0360-3016(92)90872-F

Bioreductive drugs and the selective induction of tumour hypoxia

12 November 2022

4

1 reference

https://api.crossref.org/works/10.1016/0360-3016(92)90872-F

Oral (po) dosing with RSU 1069 or RB 6145 maintains their potency as hypoxic cell radiosensitizers and cytotoxins but reduces systemic toxicity compared with parenteral (ip) administration in mice

12 November 2022

6

1 reference

https://api.crossref.org/works/10.1016/0360-3016(92)90872-F

A toxicity and pharmacokinetic study in man of the hypoxic-cell radiosensitiser RSU-1069

12 November 2022

7

1 reference

https://api.crossref.org/works/10.1016/0360-3016(92)90872-F

Synthesis and evaluation of alpha-[[(2-haloethyl)amino]methyl]-2- nitro-1H-imidazole-1-ethanols as prodrugs of alpha-[(1-aziridinyl)methyl]-2- nitro-1H-imidazole-1-ethanol (RSU-1069) and its analogues which are radiosensitizers and bioreductively ac

12 November 2022

8

1 reference

https://api.crossref.org/works/10.1016/0360-3016(92)90872-F

Induction of DNA crosslinks in vitro upon reduction of the nitroimidazole-aziridines RSU-1069 and RSU-1131

12 November 2022

9

1 reference

https://api.crossref.org/works/10.1016/0360-3016(92)90872-F

RSU 1069, a nitroimidazole containing an aziridine group. Bioreduction greatly increases cytotoxicity under hypoxic conditions

12 November 2022

10

1 reference

https://api.crossref.org/works/10.1016/0360-3016(92)90872-F

Induction of tumour hypoxia post-irradiation: a method for increasing the sensitizing efficiency of misonidazole and RSU 1069 in vivo

12 November 2022

11

1 reference

https://api.crossref.org/works/10.1016/0360-3016(92)90872-F

Dual-function radiosensitizers. Alpha-[[(2-bromoethyl)amino]methyl]-2-nitro-1H-imidazole-1-ethanol and related compounds: preparation via an aziridine equivalent

12 November 2022

13

1 reference

https://api.crossref.org/works/10.1016/0360-3016(92)90872-F

An in vitro assay to measure the viability of KHT tumor cells not previously exposed to culture conditions

12 November 2022

14

1 reference

https://api.crossref.org/works/10.1016/0360-3016(92)90872-F

Studies on the toxicity of RSU-1069

12 November 2022

15

1 reference

https://api.crossref.org/works/10.1016/0360-3016(92)90872-F

12 November 2022

Identifiers

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:1735694%20AND%20SRC:MED&resulttype=core&format=json

17 September 2019

1 reference