(Q73042518)

English

Complete analysis of the B-cell response to a protein antigen, from in vivo germinal centre formation to 3-D modelling of affinity maturation

scientific article published on 01 March 2003

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scholarly article

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31 October 2019

Complete analysis of the B-cell response to a protein antigen, from in vivo germinal centre formation to 3-D modelling of affinity maturation (English)

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12603593%20AND%20SRC:MED&resulttype=core&format=json

31 October 2019

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31 October 2019

author name string

Claire L Adams

1

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Europe PubMed Central

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31 October 2019

E James Milner-White

3

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Europe PubMed Central

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31 October 2019

Robert Aitken

4

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31 October 2019

Paul Garside

5

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31 October 2019

David I Stott

6

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31 October 2019

publication date

1 March 2003

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31 October 2019

number of pages

14

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inferred from page(s)

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Europe PubMed Central

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31 October 2019

108

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Europe PubMed Central

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31 October 2019

3

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31 October 2019

274-287

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Europe PubMed Central

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31 October 2019

Activation-induced cytidine deaminase (AID) deficiency causes the autosomal recessive form of the Hyper-IgM syndrome (HIGM2)

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2567.2003.01583.X

21 January 2018

Impaired antibody affinity maturation process characterizes a subset of patients with common variable immunodeficiency.

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2567.2003.01583.X

21 January 2018

The dynamic structure of the germinal center.

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2567.2003.01583.X

21 January 2018

Maturation of the immune response in germinal centers

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2567.2003.01583.X

21 January 2018

Somatic hypermutation

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2567.2003.01583.X

21 January 2018

V(D)J hypermutation and receptor revision: coloring outside the lines

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2567.2003.01583.X

21 January 2018

Both DNA strands of antibody genes are hypermutation targets

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2567.2003.01583.X

21 January 2018

Somatic hypermutation of immunoglobulin genes

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2567.2003.01583.X

21 January 2018

Somatic hypermutation of antibody genes: a hot spot warms up.

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2567.2003.01583.X

21 January 2018

Visualization of specific B and T lymphocyte interactions in the lymph node

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2567.2003.01583.X

21 January 2018

Th1 and Th2 CD4+ T cells provide help for B cell clonal expansion and antibody synthesis in a similar manner in vivo

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2567.2003.01583.X

21 January 2018

Ig light chain receptor editing in anergic B cells

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2567.2003.01583.X

21 January 2018

Altered immunoglobulin expression and functional silencing of self-reactive B lymphocytes in transgenic mice.

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2567.2003.01583.X

21 January 2018

Dependence of germinal center B cells on expression of CD21/CD35 for survival.

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2567.2003.01583.X

21 January 2018

The major histocompatibility complex-restricted antigen receptor on T cells. I. Isolation with a monoclonal antibody

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2567.2003.01583.X

21 January 2018

Structural differences among monoclonal antibodies with distinct fine specificities and kinetic properties

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2567.2003.01583.X

21 January 2018

Efficient amplification and direct sequencing of mouse variable regions from any immunoglobulin gene family

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2567.2003.01583.X

21 January 2018

Analysis and Comparison of the Mouse and Human Immunoglobulin Heavy Chain JH–Cμ–Cδ Locus

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2567.2003.01583.X

21 January 2018

Somatic hypermutation in the absence of DNA-dependent protein kinase catalytic subunit (DNA-PK(cs)) or recombination-activating gene (RAG)1 activity

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2567.2003.01583.X

21 January 2018

Role of BCR affinity in T cell dependent antibody responses in vivo

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2567.2003.01583.X

21 January 2018

Intraclonal generation of antibody mutants in germinal centres

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2567.2003.01583.X

21 January 2018

A recurring two-hydrogen-bond motif incorporating a serine or threonine residue is found both at alpha-helical N termini and in other situations

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2567.2003.01583.X

21 January 2018

A natural grouping of motifs with an aspartate or asparagine residue forming two hydrogen bonds to residues ahead in sequence: their occurrence at alpha-helical N termini and in other situations

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2567.2003.01583.X

21 January 2018

Role of Tyr Residues in the Contact Region of Anti-lysozyme Monoclonal Antibody HyHEL10 for Antigen Binding

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2567.2003.01583.X

21 January 2018

Conformations of immunoglobulin hypervariable regions

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2567.2003.01583.X

21 January 2018

Antigens varying in affinity for the B cell receptor induce differential B lymphocyte responses.

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2567.2003.01583.X

21 January 2018

Somatic hypermutation and selection of B cells in thymic germinal centers responding to acetylcholine receptor in myasthenia gravis

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2567.2003.01583.X

21 January 2018

Elements regulating somatic hypermutation of an immunoglobulin κ gene: Critical role for the intron enhancer/matrix attachment region

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2567.2003.01583.X

21 January 2018

Hypermutation in antibody affinity maturation

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2567.2003.01583.X

21 January 2018

Targeting of non-Ig sequences in place of the V segment by somatic hypermutation.

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2567.2003.01583.X

21 January 2018

Enhancers of hypermutation

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2567.2003.01583.X

21 January 2018

The Ig mutator is dependent on the presence, position, and orientation of the large intron enhancer

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2567.2003.01583.X

21 January 2018

Linking class-switch recombination with somatic hypermutation

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2567.2003.01583.X

21 January 2018

A mutational analysis of binding interactions in an antigen-antibody protein-protein complex

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2567.2003.01583.X

21 January 2018

Mutational analysis of the affinity maturation of antibody 48G7.

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2567.2003.01583.X

21 January 2018

B cells extract and present immobilized antigen: implications for affinity discrimination

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2567.2003.01583.X

21 January 2018

Directed evolution of antibody fragments with monovalent femtomolar antigen-binding affinity

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2567.2003.01583.X

21 January 2018

Experimental analysis by site-directed mutagenesis of somatic mutation effects on affinity and fine specificity in antibodies specific for lysozyme

1 reference

https://pubmed.ncbi.nlm.nih.gov/12603593

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Transgenic mice and analysis of B-cell tolerance

1 reference

https://pubmed.ncbi.nlm.nih.gov/12603593

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. II. A common clonal origin for periarteriolar lymphoid sheath-associated foci and germinal centers

1 reference

https://pubmed.ncbi.nlm.nih.gov/12603593

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Patterns of antibody specificity during the BALB/c immune response to hen eggwhite lysozyme

1 reference

https://pubmed.ncbi.nlm.nih.gov/12603593

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Polyreactive IgM antibodies generated from autoimmune mice and selected for histone-binding activity

1 reference

https://pubmed.ncbi.nlm.nih.gov/12603593

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Passenger transgenes reveal intrinsic specificity of the antibody hypermutation mechanism: clustering, polarity, and specific hot spots

1 reference

https://pubmed.ncbi.nlm.nih.gov/12603593

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. III. The kinetics of V region mutation and selection in germinal center B cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/12603593

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The rate of dissociation between antibody and antigen determines the efficiency of antibody-mediated antigen presentation to T cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/12603593

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Functional characterization of the somatic hypermutation process leading to antibody D1.3, a high affinity antibody directed against lysozyme

1 reference

https://pubmed.ncbi.nlm.nih.gov/12603593

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The nucleotide sequence of a 5.5-kilobase DNA segment containing the mouse kappa immunoglobulin J and C region genes

1 reference

https://pubmed.ncbi.nlm.nih.gov/12603593

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Contrasting the in situ behavior of a memory B cell clone during primary and secondary immune responses

1 reference

https://pubmed.ncbi.nlm.nih.gov/12603593

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mapping the antigenic epitope for a monoclonal antibody against lysozyme

1 reference

https://pubmed.ncbi.nlm.nih.gov/12603593

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Turbidimetric determination of lysozyme with Micrococcus lysodeikticus cells: reexamination of reaction conditions

1 reference

https://pubmed.ncbi.nlm.nih.gov/12603593

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

VL-VH expression by monoclonal antibodies recognizing avian lysozyme

1 reference

https://pubmed.ncbi.nlm.nih.gov/12603593

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Somatic mutation and the maturation of immune response to 2-phenyl oxazolone

1 reference

https://pubmed.ncbi.nlm.nih.gov/12603593

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Antigen-specific interaction between T and B cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/12603593

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular events during maturation of the immune response to oxazolone

1 reference

https://pubmed.ncbi.nlm.nih.gov/12603593

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A three-dimensional model of an anti-lysozyme antibody

1 reference

https://pubmed.ncbi.nlm.nih.gov/12603593

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Canonical structures for the hypervariable regions of immunoglobulins

1 reference

https://pubmed.ncbi.nlm.nih.gov/12603593

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Contributions of immunoglobulin heavy and light chains to antibody specificity for lysozyme and two haptens

1 reference

https://pubmed.ncbi.nlm.nih.gov/12603593

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Germinal centers

1 reference

https://pubmed.ncbi.nlm.nih.gov/12603593

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Development of antibody diversity in single germinal centers: selective expansion of high-affinity variants.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12603593

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Early high-affinity neutralizing anti-viral IgG responses without further overall improvements of affinity

1 reference

https://pubmed.ncbi.nlm.nih.gov/12603593

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Somatic hypermutation of immunoglobulin genes is linked to transcription initiation

1 reference

https://pubmed.ncbi.nlm.nih.gov/12603593

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tracing the development of single memory-lineage B cells in a highly defined immune response

1 reference

https://pubmed.ncbi.nlm.nih.gov/12603593

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Accessing the Kabat antibody sequence database by computer

1 reference

https://pubmed.ncbi.nlm.nih.gov/12603593

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The physiology of murine germinal center reactions

1 reference

https://pubmed.ncbi.nlm.nih.gov/12603593

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Germinal center development

1 reference

https://pubmed.ncbi.nlm.nih.gov/12603593

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Monitoring and interpreting the intrinsic features of somatic hypermutation

1 reference

https://pubmed.ncbi.nlm.nih.gov/12603593

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cis-acting sequences that affect somatic hypermutation of Ig genes

1 reference

https://pubmed.ncbi.nlm.nih.gov/12603593

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Affinity dependence of the B cell response to antigen: a threshold, a ceiling, and the importance of off-rate

1 reference

https://pubmed.ncbi.nlm.nih.gov/12603593

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The dynamic nature of the antibody repertoire

1 reference

https://pubmed.ncbi.nlm.nih.gov/12603593

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Structure of an antibody-antigen complex: crystal structure of the HyHEL-10 Fab-lysozyme complex

1 reference

https://pubmed.ncbi.nlm.nih.gov/12603593

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Structural correlates of high antibody affinity: three engineered amino acid substitutions can increase the affinity of an anti-p-azophenylarsonate antibody 200-fold

1 reference

https://pubmed.ncbi.nlm.nih.gov/12603593

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Induction by antigen of intrathymic apoptosis of CD4+CD8+TCRlo thymocytes in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/12603593

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1046/J.1365-2567.2003.01583.X

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12603593%20AND%20SRC:MED&resulttype=core&format=json

31 October 2019

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12603593%20AND%20SRC:MED&resulttype=core&format=json

31 October 2019

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