(Q73168250)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11069928%20AND%20SRC:MED&resulttype=core&format=json

1 November 2019

title

Limitations of cyclosporin A inhibition of the permeability transition in CNS mitochondria (English)

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11069928%20AND%20SRC:MED&resulttype=core&format=json

1 November 2019

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ChEBI release 2020-05-28

N Brustovetsky

1

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11069928%20AND%20SRC:MED&resulttype=core&format=json

1 November 2019

J M Dubinsky

series ordinal

2

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11069928%20AND%20SRC:MED&resulttype=core&format=json

1 November 2019

publication date

1 November 2000

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11069928%20AND%20SRC:MED&resulttype=core&format=json

1 November 2019

published in

Journal of Neuroscience

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11069928%20AND%20SRC:MED&resulttype=core&format=json

1 November 2019

volume

20

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11069928%20AND%20SRC:MED&resulttype=core&format=json

1 November 2019

issue

22

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11069928%20AND%20SRC:MED&resulttype=core&format=json

1 November 2019

page(s)

8229-8237

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11069928%20AND%20SRC:MED&resulttype=core&format=json

Chaotropic agents and increased matrix volume enhance binding of mitochondrial cyclophilin to the inner mitochondrial membrane and sensitize the mitochondrial permeability transition to [Ca2+]

1 November 2019

cites work

1 reference

12 December 2020

Effects of N-ethylmaleimide on the limited uptake of Ca2+, Mn2+, and Sr2+ by rat liver mitochondria

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12 December 2020

Ionized intracellular calcium concentration predicts excitotoxic neuronal death: observations with low-affinity fluorescent calcium indicators

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12 December 2020

The permeability transition in heart mitochondria is regulated synergistically by ADP and cyclosporin A.

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12 December 2020

Effect of fatty acids on energy coupling processes in mitochondria

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12 December 2020

High-affinity calcium indicators underestimate increases in intracellular calcium concentrations associated with excitotoxic glutamate stimulations

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12 December 2020

The peptide mastoparan is a potent facilitator of the mitochondrial permeability transition

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12 December 2020

Differentiation of phospholipases A in mitochondria and lysosomes of rat liver

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12 December 2020

ADP/ATP carrier protein from beef heart mitochondria has high amounts of tightly bound cardiolipin, as revealed by 31P nuclear magnetic resonance

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12 December 2020

Immunosuppressant FK506 enhances phosphorylation of nitric oxide synthase and protects against glutamate neurotoxicity

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12 December 2020

Modulation of the mitochondrial permeability transition pore. Effect of protons and divalent cations

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12 December 2020

The Ca2+-induced membrane transition in mitochondria. III. Transitional Ca2+ release

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12 December 2020

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

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12 December 2020

Transport of protons across membranes by weak acids

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12 December 2020

Mitochondrial dysfunction is a primary event in glutamate neurotoxicity

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12 December 2020

Inhibition of Ca2(+)-induced large-amplitude swelling of liver and heart mitochondria by cyclosporin is probably caused by the inhibitor binding to mitochondrial-matrix peptidyl-prolyl cis-trans isomerase and preventing it interacting with the adeni

1 reference

12 December 2020

Mitochondrial permeability transition in the central nervous system: induction by calcium cycling-dependent and -independent pathways.

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12 December 2020

Inhibitory effect of Mg2+ on the protonophoric activity of palmitic acid

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12 December 2020

Inhibition of the mitochondrial Ca2+ uniporter by pure and impure ruthenium red.

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12 December 2020

The mitochondrial permeability transition pore and its role in cell death

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12 December 2020

Contribution of the mitochondrial permeability transition to lethal injury after exposure of hepatocytes to t-butylhydroperoxide

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12 December 2020

Is the mitochondrial Ca2+ uniporter a voltage-modulated transport pathway?

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12 December 2020

Calcium-induced activation of the mitochondrial permeability transition in hippocampal neurons.

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12 December 2020

Effects of potassium, veratridine, and scorpion venom on calcium accumulation and transmitter release by nerve terminals in vitro

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12 December 2020

Amelioration by cyclosporin A of brain damage following 5 or 10 min of ischemia in rats subjected to preischemic hyperglycemia.

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12 December 2020

Mitochondrial non-specific pores remain closed during cardiac ischaemia, but open upon reperfusion

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12 December 2020

The Ca2+-induced membrane transition in mitochondria. II. Nature of the Ca2+ trigger site

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12 December 2020

Allosteric inhibition of the Ca2+-activated hydrophilic channel of the mitochondrial inner membrane by nucleotides

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12 December 2020

Dual responses of CNS mitochondria to elevated calcium

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12 December 2020

Fatty acid-induced uncoupling of oxidative phosphorylation is partly due to opening of the mitochondrial permeability transition pore.

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12 December 2020

ALBUMIN ANTAGONISM OF FATTY ACID EFFECTS ON OXIDATION AND PHOSPHORYLATION REACTIONS IN RAT LIVER MITOCHONDRIA

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12 December 2020

Regulatory aspects of rat liver mitochondrial phospholipase A2: effects of calcium ions and calmodulin

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12 December 2020

Susceptibility to apoptosis is enhanced in immature cortical neurons.

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12 December 2020

The reversible Ca2+-induced permeabilization of rat liver mitochondria

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12 December 2020

On the interactions of Ca2+ and cyclosporin A with a mitochondrial inner membrane pore: a study using cobaltammine complex inhibitors of the Ca2+ uniporter

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12 December 2020

Membrane potential of mitochondria measured with an electrode sensitive to tetraphenyl phosphonium and relationship between proton electrochemical potential and phosphorylation potential in steady state

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12 December 2020

Cyclosporin A is a potent inhibitor of the inner membrane permeability transition in liver mitochondria

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12 December 2020

Inhibition of the mitochondrial permeability transition by cyclosporin A during long time frame experiments: relationship between pore opening and the activity of mitochondrial phospholipases.

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12 December 2020

Oxidative stress, thiol reagents, and membrane potential modulate the mitochondrial permeability transition by affecting nucleotide binding to the adenine nucleotide translocase

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12 December 2020

Recent progress on regulation of the mitochondrial permeability transition pore; a cyclosporin-sensitive pore in the inner mitochondrial membrane

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12 December 2020

Mitochondrial depolarization in glutamate-stimulated neurons: an early signal specific to excitotoxin exposure

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12 December 2020

Effects of phospholipase A2 inhibitors on ruthenium red-induced Ca2+ release from mitochondria

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12 December 2020

The mitochondrial permeability transition.

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12 December 2020

The Ca2+-induced membrane transition in mitochondria. I. The protective mechanisms

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12 December 2020

Relationships between Ca2+ release, Ca2+ cycling, and Ca2+-mediated permeability changes in mitochondria

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12 December 2020

Action of cyclosporine on mitochondrial calcium fluxes

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12 December 2020

Interactions of cyclophilin with the mitochondrial inner membrane and regulation of the permeability transition pore, and cyclosporin A-sensitive channel.

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12 December 2020

Intracellular calcium levels during the period of delayed excitotoxicity

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12 December 2020

Cytochrome c release from brain mitochondria is independent of the mitochondrial permeability transition.

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12 December 2020

Cyclosporine induces neuronal apoptosis and selective oligodendrocyte death in cortical cultures.

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12 December 2020

Glutamate-induced intracellular calcium changes and neurotoxicity in cortical neurons in vitro: effect of chemical ischemia

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12 December 2020

Magnesium ion modulates the sensitivity of the mitochondrial permeability transition pore to cyclosporin A and ADP.

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12 December 2020

Inhibition by cyclosporin A of a Ca2+-dependent pore in heart mitochondria activated by inorganic phosphate and oxidative stress

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12 December 2020

Glutamate-induced mitochondrial depolarisation and perturbation of calcium homeostasis in cultured rat hippocampal neurones

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12 December 2020

Proton selective substate of the mitochondrial permeability transition pore: regulation by the redox state of the electron transport chain

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12 December 2020

Calcium induced release of mitochondrial cytochrome c by different mechanisms selective for brain versus liver.

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12 December 2020

Calcineurin and mitochondrial function in glutamate-induced neuronal cell death.

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12 December 2020

Inhibitors of permeability transition interfere with the disruption of the mitochondrial transmembrane potential during apoptosis.

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12 December 2020

Regulation of the mitochondrial Ca2+ uniporter by external adenine nucleotides: the uniporter behaves like a gated channel which is regulated by nucleotides and divalent cations

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12 December 2020

Cation transport in mitochondria--the potassium cycle

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12 December 2020

Cyclosporin A, but not FK 506, protects mitochondria and neurons against hypoglycemic damage and implicates the mitochondrial permeability transition in cell death.

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12 December 2020

Cyclosporin A delays mitochondrial depolarization induced by N-methyl-D-aspartate in cortical neurons: evidence of the mitochondrial permeability transition

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12 December 2020

Depolarization-induced mitochondrial Ca accumulation in sympathetic neurons: spatial and temporal characteristics

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12 December 2020

Modulation of the mitochondrial cyclosporin A-sensitive permeability transition pore. I. Evidence for two separate Me2+ binding sites with opposing effects on the pore open probability.

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12 December 2020

Changes in the bioenergetic state of rat hippocampus during 2.5 min of ischemia, and prevention of cell damage by cyclosporin A in hyperglycemic subjects.

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12 December 2020

10.1523/JNEUROSCI.20-22-08229.2000

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11069928%20AND%20SRC:MED&resulttype=core&format=json

1 November 2019

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11069928%20AND%20SRC:MED&resulttype=core&format=json

1 November 2019

1 reference