(Q73292849)

English

Molecular modelling of CYP2E1 enzymes from rat, mouse and man: an explanation for species differences in butadiene metabolism and potential carcinogenicity, and rationalization of CYP2E substrate specificity

scientific article published on 01 March 1997

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scholarly article

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9129165%20AND%20SRC:MED&resulttype=core&format=json

2 November 2019

Molecular modelling of CYP2E1 enzymes from rat, mouse and man: an explanation for species differences in butadiene metabolism and potential carcinogenicity, and rationalization of CYP2E substrate specificity (English)

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9129165%20AND%20SRC:MED&resulttype=core&format=json

2 November 2019

author name string

D F Lewis

1

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9129165%20AND%20SRC:MED&resulttype=core&format=json

2 November 2019

M G Bird

2

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9129165%20AND%20SRC:MED&resulttype=core&format=json

2 November 2019

D V Parke

3

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9129165%20AND%20SRC:MED&resulttype=core&format=json

2 November 2019

publication date

1 March 1997

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9129165%20AND%20SRC:MED&resulttype=core&format=json

2 November 2019

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9129165%20AND%20SRC:MED&resulttype=core&format=json

2 November 2019

118

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2 November 2019

2-3

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Europe PubMed Central

PubMed publication ID

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2 November 2019

93-113

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9129165%20AND%20SRC:MED&resulttype=core&format=json

2 November 2019

Epidemiological and mechanistic data suggest that 1,3-butadiene will not be carcinogenic to humans at exposures likely to be encountered in the environment or workplace

1 reference

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Comparison of the biotransformation of 1,3-butadiene and its metabolite, butadiene monoepoxide, by hepatic and pulmonary tissues from humans, rats and mice

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Structure of cytochrome P450eryF involved in erythromycin biosynthesis

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Human liver microsomes are efficient catalysts of 1,3-butadiene oxidation: evidence for major roles by cytochromes P450 2A6 and 2E1.

1 reference

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7 January 2021

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Orientation of cytochromes P450 in the endoplasmic reticulum

1 reference

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7 January 2021

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Replacement of Thr-303 of P450 2E1 with serine modifies the regioselectivity of its fatty acid hydroxylase activity

1 reference

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Role of human cytochromes P450 in the metabolic activation of chemical carcinogens and toxins

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Camphor binding by Pseudomonas putida cytochrome P-450. Kinetics and thermodynamics of the reaction

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Role of human cytochrome P-450 IIE1 in the oxidation of many low molecular weight cancer suspects

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Role of free radicals and catalytic metal ions in human disease: an overview

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7 January 2021

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Structure and function of cytochromes P450: a comparative analysis of three crystal structures.

1 reference

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DNA strand cleavage as a sensitive assay for the production of hydroxyl radicals by microsomes: role of cytochrome P4502E1 in the increased activity after ethanol treatment

1 reference

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7 January 2021

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Quantitative structure-activity relationships in a series of alcohols exhibiting inhibition of cytochrome P-450-mediated aniline hydroxylation

1 reference

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7 January 2021

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Three-dimensional models of human and other mammalian microsomal P450s constructed from an alignment with P450102 (P450bm3)

1 reference

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7 January 2021

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Molecular modelling of members of the P4502A subfamily: application to studies of enzyme specificity

1 reference

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7 January 2021

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Molecular modeling of enzymes and receptors involved in carcinogenesis: QSARs and compact-3D.

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7 January 2021

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Interaction of a series of nitriles with the alcohol-inducible isoform of P450: computer analysis of structure-activity relationships

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7 January 2021

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A quantitative structure-activity relationship study on a series of 10 para-substituted toluenes binding to cytochrome P4502B4 (CYP2B4), and their hydroxylation rates

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7 January 2021

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Life-span and cancer: the induction time of tumors in diverse animal species treated with nitrosodiethylamine

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7 January 2021

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Effects of ether anaesthesia and fasting on various cytochromes P450 of rat liver and kidney.

1 reference

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7 January 2021

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Active site topology of human cytochrome P450 2E1.

1 reference

https://api.crossref.org/works/10.1016%2FS0300-483X%2896%2903583-4

7 January 2021

based on heuristic

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Mechanistic data indicate that 1,3-butadiene is a human carcinogen

1 reference

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7 January 2021

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Cytochrome P450-related differences between rats and mice in the metabolism of benzene, toluene and trichloroethylene in liver microsomes

1 reference

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7 January 2021

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The P450 superfamily: update on new sequences, gene mapping, accession numbers, early trivial names of enzymes, and nomenclature

1 reference

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7 January 2021

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Activation mechanisms to chemical toxicity

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Relationships between the electrostatic potential, epoxide hydrase inhibition and carcinogenicity for some hydrocarbon and halogenated hydrocarbon epoxides

1 reference

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7 January 2021

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High-resolution crystal structure of cytochrome P450cam

1 reference

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7 January 2021

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Bioactivation of halogenated hydrocarbons by cytochrome P4502E1.

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7 January 2021

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Crystal structure of hemoprotein domain of P450BM-3, a prototype for microsomal P450's

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7 January 2021

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Mathematical model supporting the superoxide theory of oxygen toxicity

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Active site mechanics of liver microsomal cytochrome P-450.

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Cytochrome P450IIE1: roles in nitrosamine metabolism and mechanisms of regulation

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Identifiers

10.1016/S0300-483X(96)03583-4

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9129165%20AND%20SRC:MED&resulttype=core&format=json

2 November 2019

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9129165%20AND%20SRC:MED&resulttype=core&format=json

2 November 2019

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