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Ras signaling through PI3K confers hormone-independent proliferation that is compatible with differentiation
scientific article published on 01 February 2000
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Europe PubMed Central
PubMed publication ID
10702801
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10702801%20AND%20SRC:MED&resulttype=core&format=json
retrieved
4 November 2019
title
Ras signaling through PI3K confers hormone-independent proliferation that is compatible with differentiation
(English)
1 reference
stated in
Europe PubMed Central
PubMed publication ID
10702801
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10702801%20AND%20SRC:MED&resulttype=core&format=json
retrieved
4 November 2019
author name string
Cass LA
series ordinal
1
1 reference
stated in
Europe PubMed Central
PubMed publication ID
10702801
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10702801%20AND%20SRC:MED&resulttype=core&format=json
retrieved
4 November 2019
Meinkoth JL
series ordinal
2
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Europe PubMed Central
PubMed publication ID
10702801
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10702801%20AND%20SRC:MED&resulttype=core&format=json
retrieved
4 November 2019
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English
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publication date
1 February 2000
1 reference
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Europe PubMed Central
PubMed publication ID
10702801
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10702801%20AND%20SRC:MED&resulttype=core&format=json
retrieved
4 November 2019
published in
Oncogene
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Europe PubMed Central
PubMed publication ID
10702801
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10702801%20AND%20SRC:MED&resulttype=core&format=json
retrieved
4 November 2019
volume
19
1 reference
stated in
Europe PubMed Central
PubMed publication ID
10702801
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10702801%20AND%20SRC:MED&resulttype=core&format=json
retrieved
4 November 2019
issue
7
1 reference
stated in
Europe PubMed Central
PubMed publication ID
10702801
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10702801%20AND%20SRC:MED&resulttype=core&format=json
retrieved
4 November 2019
page(s)
924-932
1 reference
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Europe PubMed Central
PubMed publication ID
10702801
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10702801%20AND%20SRC:MED&resulttype=core&format=json
retrieved
4 November 2019
cites work
Thyrotropin-induced mitogenesis is Ras dependent but appears to bypass the Raf-dependent cytoplasmic kinase cascade
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Inhibition of the Phosphatidylinositol 3-Kinase/p70S6-Kinase Pathway Induces B16 Melanoma Cell Differentiation
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Protein kinase A-dependent and -independent signaling pathways contribute to cyclic AMP-stimulated proliferation.
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Phosphatidylinositol 3-kinase activation is required for insulin stimulation of pp70 S6 kinase, DNA synthesis, and glucose transporter translocation
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Concomitant activation of MEK-1 and Rac-1 increases the proliferative potential of thyroid epithelial cells, without affecting their differentiation.
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Cloning and characterization of the thyroid iodide transporter
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Role of phosphoinositide-3-OH kinase in Ras signaling.
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Mechanism of action of the immunosuppressant rapamycin
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Molecular genetics of human thyroid neoplasms
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Distinct phosphotyrosines on a growth factor receptor bind to specific molecules that mediate different signaling pathways
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Multiple mechanisms of interference between transformation and differentiation in thyroid cells
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Differential effects of constitutively active phosphatidylinositol 3-kinase on glucose transport, glycogen synthase activity, and DNA synthesis in 3T3-L1 adipocytes
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One- and two-step transformations of rat thyroid epithelial cells by retroviral oncogenes
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Ral-specific guanine nucleotide exchange factor activity opposes other Ras effectors in PC12 cells by inhibiting neurite outgrowth
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Microinjection of the SH2 domain of the 85-kilodalton subunit of phosphatidylinositol 3-kinase inhibits insulin-induced DNA synthesis and c-fos expression
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An essential role of phosphatidylinositol 3-kinase in myogenic differentiation.
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Stimulation of membrane ruffling and MAP kinase activation by distinct effectors of RAS.
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Phosphatidylinositol 3-kinase inhibitors block differentiation of skeletal muscle cells
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7 January 2021
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Na(+)-I- symport activity is present in membrane vesicles from thyrotropin-deprived non-I(-)-transporting cultured thyroid cells
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7 January 2021
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Overexpression of catalytic subunit p110alpha of phosphatidylinositol 3-kinase increases glucose transport activity with translocation of glucose transporters in 3T3-L1 adipocytes
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7 January 2021
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GTPase-activating protein and phosphatidylinositol 3-kinase bind to distinct regions of the platelet-derived growth factor receptor beta subunit
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7 January 2021
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Activation of Rac1, RhoA, and mitogen-activated protein kinases is required for Ras transformation
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Oncogenic Ras activation of Raf/mitogen-activated protein kinase-independent pathways is sufficient to cause tumorigenic transformation
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Matrix adhesion and Ras transformation both activate a phosphoinositide 3-OH kinase and protein kinase B/Akt cellular survival pathway
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Activation of phosphatidylinositol 3-kinase is sufficient for cell cycle entry and promotes cellular changes characteristic of oncogenic transformation
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Crossref
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7 January 2021
based on heuristic
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Inhibition of thyrotropin-stimulated DNA synthesis by microinjection of inhibitors of cellular Ras and cyclic AMP-dependent protein kinase
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Crossref
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Characterization of the thyroid Na+/I- symporter with an anti-COOH terminus antibody
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Nutrition and oral cancer
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Ras effectors
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Crossref
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https://api.crossref.org/works/10.1038%2FSJ.ONC.1203393
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7 January 2021
based on heuristic
inferred from DOI database lookup
Activated phosphatidylinositol 3-kinase is sufficient to mediate actin rearrangement and GLUT4 translocation in 3T3-L1 adipocytes
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Crossref
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7 January 2021
based on heuristic
inferred from DOI database lookup
Regulation of myeloid cell growth by distinct effectors of Ras.
1 reference
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Crossref
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https://api.crossref.org/works/10.1038%2FSJ.ONC.1203393
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7 January 2021
based on heuristic
inferred from DOI database lookup
RalGDS functions in Ras- and cAMP-mediated growth stimulation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1203393
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7 January 2021
based on heuristic
inferred from DOI database lookup
Differential effects of protein kinase A on Ras effector pathways
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1203393
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Molecular events involved in differentiation of thyroid follicular cells.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1203393
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7 January 2021
based on heuristic
inferred from DOI database lookup
The paired-domain transcription factor Pax8 binds to the upstream enhancer of the rat sodium/iodide symporter gene and participates in both thyroid-specific and cyclic-AMP-dependent transcription
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1203393
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7 January 2021
based on heuristic
inferred from DOI database lookup
Phosphatidylinositol 3-kinase is a negative regulator of cellular differentiation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1203393
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7 January 2021
based on heuristic
inferred from DOI database lookup
The modular phosphorylation and activation of p70s6k.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1203393
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7 January 2021
based on heuristic
inferred from DOI database lookup
An essential role for Rac in Ras transformation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1203393
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Signaling through mitogen-activated protein kinase and Rac/Rho does not duplicate the effects of activated Ras on skeletal myogenesis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1203393
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7 January 2021
based on heuristic
inferred from DOI database lookup
A role for RalGDS and a novel Ras effector in the Ras-mediated inhibition of skeletal myogenesis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1203393
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7 January 2021
based on heuristic
inferred from DOI database lookup
The phosphatidylinositol 3-kinase alpha is required for DNA synthesis induced by some, but not all, growth factors
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1203393
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Role of phosphoinositide 3-OH kinase in cell transformation and control of the actin cytoskeleton by Ras
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1203393
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Moderate doses of iodide in vivo inhibit cell proliferation and the expression of thyroperoxidase and Na+/I− symporter mRNAs in dog thyroid
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1203393
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Multiple Ras functions can contribute to mammalian cell transformation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1203393
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Ras‐effector interactions, the problem of specificity
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1203393
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Origin and progression of thyroid epithelial tumours: cellular and molecular mechanisms
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1203393
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identifiers
DOI
10.1038/SJ.ONC.1203393
1 reference
stated in
Europe PubMed Central
PubMed publication ID
10702801
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10702801%20AND%20SRC:MED&resulttype=core&format=json
retrieved
4 November 2019
Dimensions Publication ID
1012789236
0 references
PubMed publication ID
10702801
1 reference
stated in
Europe PubMed Central
PubMed publication ID
10702801
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10702801%20AND%20SRC:MED&resulttype=core&format=json
retrieved
4 November 2019
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