(Q73763988)

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Significant change in the structure of a ribozyme upon introduction of a phosphorothioate linkage at P9: NMR reveals a conformational fluctuation in the core region of a hammerhead ribozyme

scientific article published on 01 May 2000

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6 November 2019

Significant change in the structure of a ribozyme upon introduction of a phosphorothioate linkage at P9: NMR reveals a conformational fluctuation in the core region of a hammerhead ribozyme (English)

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6 November 2019

Koichi Yoshinari

3

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6 November 2019

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K Suzumura

1

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6 November 2019

M Warashina

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6 November 2019

Y Tanaka

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6 November 2019

T Kuwabara

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6 November 2019

M Orita

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6 November 2019

K Taira

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6 November 2019

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1 May 2000

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6 November 2019

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6 November 2019

473

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6 November 2019

1

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6 November 2019

106-112

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6 November 2019

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Self-cleavage of virusoid RNA is performed by the proposed 55-nucleotide active site

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Metal ion catalysis in the Tetrahymena ribozyme reaction

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A general two-metal-ion mechanism for catalytic RNA

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Ribozymes: a distinct class of metalloenzymes

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How many catalytic RNAs? Ions and the Cheshire cat conjecture.

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Evidence for the role of solvated metal hydroxide in the hammerhead cleavage mechanism

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Observations on catalysis by hammerhead ribozymes are consistent with a two-divalent-metal-ion mechanism

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7 January 2021

Explanation by the double-metal-ion mechanism of catalysis for the differential metal ion effects on the cleavage rates of 5'-oxy and 5'-thio substrates by a hammerhead ribozyme

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7 January 2021

The structure, function and application of the hammerhead ribozyme

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7 January 2021

A two-metal ion mechanism operates in the hammerhead ribozyme-mediated cleavage of an RNA substrate

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7 January 2021

The Hydrolysis of RNA: From Theoretical Calculations to the Hammerhead Ribozyme-Mediated Cleavage of RNA

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7 January 2021

Structure, folding and catalysis of the small nucleolytic ribozymes

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7 January 2021

Identification of the hammerhead ribozyme metal ion binding site responsible for rescue of the deleterious effect of a cleavage site phosphorothioate

1 reference

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7 January 2021

A further investigation and reappraisal of the thio effect in the cleavage reaction catalyzed by a hammerhead ribozyme

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7 January 2021

The hammerhead, hairpin and VS ribozymes are catalytically proficient in monovalent cations alone

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7 January 2021

Three-dimensional structure of a hammerhead ribozyme

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7 January 2021

The crystal structure of an all-RNA hammerhead ribozyme: a proposed mechanism for RNA catalytic cleavage

1 reference

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7 January 2021

The structural basis of hammerhead ribozyme self-cleavage

1 reference

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7 January 2021

Thiophosphate interference experiments locate phosphates important for the hammerhead RNA self-cleavage reaction

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7 January 2021

Sequence requirements of the hammerhead RNA self-cleavage reaction

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7 January 2021

Hammerhead ribozymes: importance of stem-loop II for activity

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7 January 2021

Involvement of a specific metal ion in the transition of the hammerhead ribozyme to its catalytic conformation.

1 reference

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7 January 2021

Magnesium-mediated conversion of an inactive form of a hammerhead ribozyme to an active complex with its substrate. An investigation by NMR spectroscopy

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7 January 2021

Ionic interactions and the global conformations of the hammerhead ribozyme

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7 January 2021

Structure of an anti-HIV-1 hammerhead ribozyme complex with a 17-mer DNA substrate analog of HIV-1 gag RNA and a mechanism for the cleavage reaction: 750 MHz NMR and computer experiments

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7 January 2021

Identification and characterization of a novel high affinity metal-binding site in the hammerhead ribozyme

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7 January 2021

Formation of a catalytically active dimer by tRNA(Val)-driven short ribozymes

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7 January 2021

A novel allosterically trans-activated ribozyme, the maxizyme, with exceptional specificity in vitro and in vivo

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7 January 2021

Maxizymes, novel allosterically controllable ribozymes, can be designed to cleave various substrates

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A general purpose RNA-cleaving DNA enzyme

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Extremely high and specific activity of DNA enzymes in cells with a Philadelphia chromosome

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Nuclease-resistant chimeric ribozymes containing deoxyribonucleotides and phosphorothioate linkages

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Phosphorothioate-modified oligodeoxyribonucleotides. III. NMR and UV spectroscopic studies of the Rp-Rp, Sp-Sp, and Rp-Sp duplexes, [d(GGSAATTCC)]2, derived from diastereomeric O-ethyl phosphorothioates

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NMR investigations of duplex stability of phosphorothioate and phosphorodithioate DNA analogues modified in both strands

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Nuclear magnetic resonance studies of the hammerhead ribozyme domain. Secondary structure formation and magnesium ion dependence

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Sequence-dependent structural variations of hammerhead RNA enzymes

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Synthesis and NMR study of ribo-oligonucleotides forming a hammerhead-type RNA enzyme system

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Characterization of the secondary structure and melting of a self-cleaved RNA hammerhead domain by proton NMR spectroscopy

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Structural principles for the inhibition of the 3'-5' exonuclease activity of Escherichia coli DNA polymerase I by phosphorothioates

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Identifiers

10.1016/S0014-5793(00)01499-X

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10802069%20AND%20SRC:MED&resulttype=core&format=json

6 November 2019

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10802069%20AND%20SRC:MED&resulttype=core&format=json

6 November 2019

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