(Q74250453)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9484790%20AND%20SRC:MED&resulttype=core&format=json

9 November 2019

title

Pharmacological and biochemical determinants of the antitumour activity of the indoloquinone EO9 (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9484790%20AND%20SRC:MED&resulttype=core&format=json

9 November 2019

author name string

J Cummings

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9484790%20AND%20SRC:MED&resulttype=core&format=json

9 November 2019

V J Spanswick

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9484790%20AND%20SRC:MED&resulttype=core&format=json

9 November 2019

J Gardiner

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9484790%20AND%20SRC:MED&resulttype=core&format=json

9 November 2019

A Ritchie

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9484790%20AND%20SRC:MED&resulttype=core&format=json

9 November 2019

J F Smyth

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9484790%20AND%20SRC:MED&resulttype=core&format=json

9 November 2019

language of work or name

English

0 references

publication date

1 February 1998

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9484790%20AND%20SRC:MED&resulttype=core&format=json

9 November 2019

published in

Biochemical Pharmacology

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9484790%20AND%20SRC:MED&resulttype=core&format=json

9 November 2019

volume

55

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9484790%20AND%20SRC:MED&resulttype=core&format=json

9 November 2019

issue

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9484790%20AND%20SRC:MED&resulttype=core&format=json

9 November 2019

page(s)

253-260

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9484790%20AND%20SRC:MED&resulttype=core&format=json

Development, pharmacology, role of DT-diaphorase and prospects of the indoloquinone EO9.

9 November 2019

cites work

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2897%2900265-7

The autoxidation of the reduced forms of EO9

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2897%2900265-7

EO9: a novel bioreductive alkylating indoloquinone with preferential solid tumour activity and lack of bone marrow toxicity in preclinical models

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2897%2900265-7

DT-diaphorase activity correlates with sensitivity to the indoloquinone EO9 in mouse and human colon carcinomas

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2897%2900265-7

Phase I and pharmacologic study of the novel indoloquinone bioreductive alkylating cytotoxic drug E09.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2897%2900265-7

Bioreductive drugs as post-irradiation sensitizers: comparison of dual function agents with SR 4233 and the mitomycin C analogue EO9

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2897%2900265-7

Factors affecting sensitivity to EO9 in rodent and human tumour cells in vitro: DT-diaphorase activity and hypoxia

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2897%2900265-7

A randomized phase II study with two schedules of the novel indoloquinone EO9 in non-small-cell lung cancer: a study of the EORTC Early Clinical Studies Group (ECSG)

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2897%2900265-7

Gradient high-performance liquid chromatographic assay for the determination of the novel indoloquinone antitumour agent E09 in biological specimens

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2897%2900265-7

Enzymology of mitomycin C metabolic activation in tumour tissue. Characterization of a novel mitochondrial reductase

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2897%2900265-7

EO9: relationship between DT-diaphorase levels and response in vitro and in vivo

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2897%2900265-7

The sensitivity of human tumour cells to quinone bioreductive drugs: what role for DT-diaphorase?

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2897%2900265-7

Unusually marked hypoxic sensitization to indoloquinone EO9 and mitomycin C in a human colon-tumour cell line that lacks DT-diaphorase activity.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2897%2900265-7

DT-diaphorase activity in normal and neoplastic human tissues; an indicator for sensitivity to bioreductive agents?

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2897%2900265-7

DT-diaphorase protects cells from the hypoxic cytotoxicity of indoloquinone EO9.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2897%2900265-7

In vitro activity of the novel indoloquinone EO-9 and the influence of pH on cytotoxicity.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2897%2900265-7

Indoloquinone EO9: DNA interstrand cross-linking upon reduction by DT-diaphorase or xanthine oxidase

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2897%2900265-7

Chemosensitivity to the indoloquinone EO9 is correlated with DT-diaphorase activity and its gene expression

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2897%2900265-7

Reductase enzyme expression across the National Cancer Institute Tumor cell line panel: correlation with sensitivity to mitomycin C and EO9.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2897%2900265-7

The Role of NAD(P)H: Quinone Reductase (EC 1.6.99.2, DT-Diaphorase) in the Reductive Bioactivation of the Novel Indoloquinone Antitumor Agent E09

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2897%2900265-7

Structure-activity relationships for DT-diaphorase reduction of hypoxic cell directed agents: indoloquinones and diaziridinyl benzoquinones

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2897%2900265-7

10.1016/S0006-2952(97)00265-7

7 January 2021

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9484790%20AND%20SRC:MED&resulttype=core&format=json

9 November 2019

1 reference