(Q79270328)

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20 December 2019

title

Synergistic effect of arsenic trioxide and flt3 inhibition on cells with flt3 internal tandem duplication (English)

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20 December 2019

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1

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20 December 2019

author name string

Hideo Harigae

2

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20 December 2019

Hisayuki Yokoyama

3

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20 December 2019

Izumi Ishikawa

4

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20 December 2019

Shouri Abe

5

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20 December 2019

Masue Imaizumi

6

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20 December 2019

Takeshi Sasaki

7

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20 December 2019

Mitsuo Kaku

8

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20 December 2019

publication date

1 October 2006

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International Journal of Hematology

20 December 2019

published in

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20 December 2019

volume

84

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20 December 2019

issue

3

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20 December 2019

page(s)

256-261

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https://scigraph.springernature.com/pub.10.1532/ijh97.06076

20 December 2019

exact match

0 references

cites work

Human leukemias with mutated FLT3 kinase are synergistically sensitive to FLT3 and Hsp90 inhibitors: the key role of the STAT5 signal transduction pathway

1 reference

12 December 2020

Inverse correlation between Flt3 and PU.1 expression in acute myeloblastic leukemias

1 reference

12 December 2020

Inhibition of the transforming activity of FLT3 internal tandem duplication mutants from AML patients by a tyrosine kinase inhibitor

1 reference

12 December 2020

Cloning of a coproporphyrinogen oxidase promoter regulatory element binding protein

1 reference

12 December 2020

NB4, a maturation inducible cell line with t(15;17) marker isolated from a human acute promyelocytic leukemia (M3).

1 reference

12 December 2020

MEK1 inhibition sensitizes primary acute myelogenous leukemia to arsenic trioxide-induced apoptosis.

1 reference

12 December 2020

CHIR-258: a potent inhibitor of FLT3 kinase in experimental tumor xenograft models of human acute myelogenous leukemia

1 reference

12 December 2020

The MEK inhibitor, PD98059, reduces survival but does not block acute myeloid leukemia blast maturation in vitro

1 reference

12 December 2020

Transient poly(ADP-ribosyl)ation of nuclear proteins and role of poly(ADP-ribose) polymerase in the early stages of apoptosis

1 reference

12 December 2020

The stress inducer arsenite activates mitogen-activated protein kinases extracellular signal-regulated kinases 1 and 2 via a MAPK kinase 6/p38-dependent pathway

1 reference

12 December 2020

Block of C/EBP alpha function by phosphorylation in acute myeloid leukemia with FLT3 activating mutations.

1 reference

12 December 2020

Arsenic trioxide (ATO) and MEK1 inhibition synergize to induce apoptosis in acute promyelocytic leukemia cells.

1 reference

12 December 2020

Cotreatment with 17-allylamino-demethoxygeldanamycin and FLT-3 kinase inhibitor PKC412 is highly effective against human acute myelogenous leukemia cells with mutant FLT-3.

1 reference

12 December 2020

Importance of MEK-1/-2 signaling in monocytic and granulocytic differentiation of myeloid cell lines

1 reference

12 December 2020

Patients with acute myeloid leukemia and an activating mutation in FLT3 respond to a small-molecule FLT3 tyrosine kinase inhibitor, PKC412.

1 reference

12 December 2020

Downmodulation of ERK activity inhibits the proliferation and induces the apoptosis of primary acute myelogenous leukemia blasts

1 reference

12 December 2020

A phase 1 study of SU11248 in the treatment of patients with refractory or resistant acute myeloid leukemia (AML) or not amenable to conventional therapy for the disease

1 reference

12 December 2020

The expression of P-glycoprotein in AML cells with FLT3 internal tandem duplications is associated with reduced apoptosis in response to FLT3 inhibitors

1 reference

12 December 2020

The roles of FLT3 in hematopoiesis and leukemia

1 reference

12 December 2020

Internal tandem duplication of the FLT3 gene is preferentially seen in acute myeloid leukemia and myelodysplastic syndrome among various hematological malignancies. A study on a large series of patients and cell lines

1 reference

12 December 2020

Arsenic trioxide: new clinical experience with an old medication in hematologic malignancies

1 reference

12 December 2020

Cell-cycle-dependent activation of mitogen-activated protein kinase kinase (MEK-1/2) in myeloid leukemia cell lines and induction of growth inhibition and apoptosis by inhibitors of RAS signaling

1 reference

12 December 2020

The Flt3 internal tandem duplication mutant inhibits the function of transcriptional repressors by blocking interactions with SMRT

1 reference

12 December 2020

Acute myeloid leukemia

1 reference

12 December 2020

Arsenic trioxide, a therapeutic agent for APL.

1 reference

12 December 2020

In vitro studies of a FLT3 inhibitor combined with chemotherapy: sequence of administration is important to achieve synergistic cytotoxic effects

1 reference

12 December 2020

FLT3 internal tandem duplication mutations associated with human acute myeloid leukemias induce myeloproliferative disease in a murine bone marrow transplant model

1 reference

12 December 2020

Synergistic effect of SU11248 with cytarabine or daunorubicin on FLT3 ITD-positive leukemic cells

1 reference

12 December 2020

Requirement of Erk, but not JNK, for arsenite-induced cell transformation

1 reference

12 December 2020

FLT3 mutations in acute myeloid leukemia cell lines

1 reference

12 December 2020

Tandem-duplicated Flt3 constitutively activates STAT5 and MAP kinase and introduces autonomous cell growth in IL-3-dependent cell lines

1 reference

12 December 2020

Therapeutic targeting of the MEK/MAPK signal transduction module in acute myeloid leukemia

1 reference

12 December 2020

The FLT3 internal tandem duplication mutation prevents apoptosis in interleukin-3-deprived BaF3 cells due to protein kinase A and ribosomal S6 kinase 1-mediated BAD phosphorylation at serine 112.

1 reference

12 December 2020

AML1B transcriptional repressor function is impaired by the Flt3-internal tandem duplication

1 reference

12 December 2020

Inhibition of the MEK/MAPK signal transduction pathway strongly impairs the growth of Flt3-ITD cells

1 reference

12 December 2020

The tumor promoter arsenite stimulates AP-1 activity by inhibiting a JNK phosphatase

1 reference

12 December 2020

Flt3 mutation activates p21WAF1/CIP1 gene expression through the action of STAT5.

1 reference

12 December 2020

Establishment of a new peroxidase-positive human myeloid cell line, PL-21

1 reference

12 December 2020

Over-expression of Flt3 induces NF-kappaB pathway and increases the expression of IL-6.

1 reference

12 December 2020

Identifiers

DOI

10.1532/IJH97.06076

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17050201%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

20 December 2019

0 references

1 reference