(Q40493341)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15538402%20AND%20SRC:MED&resulttype=core&format=json

5 January 2020

title

Arsenic trioxide (ATO) and MEK1 inhibition synergize to induce apoptosis in acute promyelocytic leukemia cells (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15538402%20AND%20SRC:MED&resulttype=core&format=json

acute promyelocytic leukemia

5 January 2020

main subject

apoptotic process

0 references

1 reference

1

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5 January 2020

author name string

A Tabilio

2

1 reference

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5 January 2020

F Lo-Coco

3

1 reference

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5 January 2020

P G Pelicci

4

1 reference

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5 January 2020

A Bonati

5

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5 January 2020

publication date

1 February 2005

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5 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15538402%20AND%20SRC:MED&resulttype=core&format=json

5 January 2020

volume

19

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5 January 2020

issue

2

1 reference

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5 January 2020

page(s)

234-244

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https://scigraph.springernature.com/pub.10.1038/sj.leu.2403585

5 January 2020

exact match

0 references

cites work

Complete remission after treatment of acute promyelocytic leukemia with arsenic trioxide

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403585

United States multicenter study of arsenic trioxide in relapsed acute promyelocytic leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403585

Acute promyelocytic leukemia: evolving therapeutic strategies

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403585

Arsenic trioxide-induced apoptosis and differentiation are associated respectively with mitochondrial transmembrane potential collapse and retinoic acid signaling pathways in acute promyelocytic leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403585

History of the development of arsenic derivatives in cancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403585

Combined effect of all-trans retinoic acid and arsenic trioxide in acute promyelocytic leukemia cells in vitro and in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403585

Acquisition of potential N-glycosylation sites in the immunoglobulin variable region by somatic mutation is a distinctive feature of follicular lymphoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403585

Therapeutic targeting of the MEK/MAPK signal transduction module in acute myeloid leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403585

Synergistic induction of apoptosis by simultaneous disruption of the Bcl-2 and MEK/MAPK pathways in acute myelogenous leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403585

Map kinase signaling pathways and hematologic malignancies

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403585

The Raf/MEK/ERK signal transduction cascade as a target for chemotherapeutic intervention in leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403585

PD 098059 is a specific inhibitor of the activation of mitogen-activated protein kinase kinase in vitro and in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403585

Blockade of the MAP kinase pathway suppresses growth of colon tumors in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403585

Arsenic trioxide as an inducer of apoptosis and loss of PML/RAR alpha protein in acute promyelocytic leukemia cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403585

Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403585

Transient poly(ADP-ribosyl)ation of nuclear proteins and role of poly(ADP-ribose) polymerase in the early stages of apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403585

Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403585

Specific inhibition of gene expression by small double-stranded RNAs in invertebrate and vertebrate systems

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403585

Dissociation of cytokine-induced phosphorylation of Bad and activation of PKB/akt: involvement of MEK upstream of Bad phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403585

Cell survival promoted by the Ras-MAPK signaling pathway by transcription-dependent and -independent mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403585

Regulation of bad phosphorylation and association with Bcl-x(L) by the MAPK/Erk kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403585

Regulation of BAD phosphorylation at serine 112 by the Ras-mitogen-activated protein kinase pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403585

Bad, a heterodimeric partner for Bcl-XL and Bcl-2, displaces Bax and promotes cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403585

Dimerization properties of human BAD. Identification of a BH-3 domain and analysis of its binding to mutant BCL-2 and BCL-XL proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403585

The stress inducer arsenite activates mitogen-activated protein kinases extracellular signal-regulated kinases 1 and 2 via a MAPK kinase 6/p38-dependent pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403585

Tumor promoter arsenite activates extracellular signal-regulated kinase through a signaling pathway mediated by epidermal growth factor receptor and Shc.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403585

Signal transduction mediated by the Ras/Raf/MEK/ERK pathway from cytokine receptors to transcription factors: potential targeting for therapeutic intervention.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403585

Requirement for ERK activation in cisplatin-induced apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403585

MEK/ERK pathway protects ionizing radiation-induced loss of mitochondrial membrane potential and cell death in lymphocytic leukemia cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403585

Activation of extracellular signal-regulated kinase by ultraviolet is mediated through Src-dependent epidermal growth factor receptor phosphorylation. Its implication in an anti-apoptotic function

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403585

Activation of RSK by UV-light: phosphorylation dynamics and involvement of the MAPK pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403585

Serine phosphorylation of death agonist BAD in response to survival factor results in binding to 14-3-3 not BCL-X(L)

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403585

Epidermal growth factor receptor-dependent control of keratinocyte survival and Bcl-xL expression through a MEK-dependent pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403585

Fibroblast growth factor-2 induces translational regulation of Bcl-XL and Bcl-2 via a MEK-dependent pathway: correlation with resistance to etoposide-induced apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403585

Increased Bcl-xL expression mediates v-Src-induced resistance to anoikis in intestinal epithelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403585

Identification of a novel Bcl-xL phosphorylation site regulating the sensitivity of taxol- or 2-methoxyestradiol-induced apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403585

Bcl-xL deamidation is a critical switch in the regulation of the response to DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403585

Receptor- and mitochondrial-mediated apoptosis in acute leukemia: a translational view

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403585

Susceptibility to drug-induced apoptosis correlates with differential modulation of Bad, Bcl-2 and Bcl-xL protein levels

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403585

Development of anticancer drugs targeting the MAP kinase pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403585

Pharmacological inhibitors of MAPK pathways.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403585

Treatment with arsenic trioxide (ATO) and MEK1 inhibitor activates the p73-p53AIP1 apoptotic pathway in leukemia cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403585

p53AIP1, a potential mediator of p53-dependent apoptosis, and its regulation by Ser-46-phosphorylated p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403585

DNA damage-dependent acetylation of p73 dictates the selective activation of apoptotic target genes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403585

Inhibition of phosphatidylinositol 3-kinase dephosphorylates BAD and promotes apoptosis in myeloid leukemias

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403585

Cytokine-regulated expression of survivin in myeloid leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403585

Regulation and targeting of antiapoptotic XIAP in acute myeloid leukemia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403585

Requirement for the PI3K/Akt pathway in MEK1-mediated growth and prevention of apoptosis: identification of an Achilles heel in leukemia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403585

Phosphorylation of PML by mitogen-activated protein kinases plays a key role in arsenic trioxide-mediated apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403585

Death by arsenic: implications of PML sumoylation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403585

Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signal-regulated kinase activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403585

Constitutive activation of mitogen-activated protein kinase pathway in acute leukemia cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403585

7 January 2021

Downmodulation of ERK activity inhibits the proliferation and induces the apoptosis of primary acute myelogenous leukemia blasts

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403585

7 January 2021

The MEK inhibitor, PD98059, reduces survival but does not block acute myeloid leukemia blast maturation in vitro

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403585

7 January 2021

Ligation of the CD44 adhesion molecule reverses blockage of differentiation in human acute myeloid leukemia

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403585

7 January 2021

MEK inhibition enhances paclitaxel-induced tumor apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403585

7 January 2021

Selective induction of apoptosis of NB4 cells from G2+M phase by sodium arsenite at lower doses.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403585

7 January 2021

MEK wars, a new front in the battle against cancer

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403585

7 January 2021

Identifiers

DOI

10.1038/SJ.LEU.2403585

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15538402%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

5 January 2020

0 references

1 reference