(Q79408938)

English

Activation of extracellular regulated kinases (ERK1/2) but not AKT predicts poor prognosis in colorectal carcinoma and is associated with k-ras mutations

scientific article published on 01 February 2007

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scholarly article

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17149612%20AND%20SRC:MED&resulttype=core&format=json

22 December 2019

Activation of extracellular regulated kinases (ERK1/2) but not AKT predicts poor prognosis in colorectal carcinoma and is associated with k-ras mutations (English)

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17149612%20AND%20SRC:MED&resulttype=core&format=json

22 December 2019

colorectal carcinoma

1 reference

based on heuristic

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author name string

K J Schmitz

1

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Europe PubMed Central

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22 December 2019

J Wohlschlaeger

2

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17149612%20AND%20SRC:MED&resulttype=core&format=json

22 December 2019

H Alakus

3

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17149612%20AND%20SRC:MED&resulttype=core&format=json

22 December 2019

J Bohr

4

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17149612%20AND%20SRC:MED&resulttype=core&format=json

22 December 2019

M A Stauder

5

1 reference

Europe PubMed Central

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22 December 2019

K Worm

6

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17149612%20AND%20SRC:MED&resulttype=core&format=json

22 December 2019

G Winde

7

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17149612%20AND%20SRC:MED&resulttype=core&format=json

22 December 2019

K W Schmid

8

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17149612%20AND%20SRC:MED&resulttype=core&format=json

22 December 2019

H A Baba

9

1 reference

Europe PubMed Central

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22 December 2019

publication date

1 February 2007

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Europe PubMed Central

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22 December 2019

Virchows Archiv

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17149612%20AND%20SRC:MED&resulttype=core&format=json

22 December 2019

450

1 reference

Europe PubMed Central

PubMed publication ID

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22 December 2019

2

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Europe PubMed Central

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22 December 2019

151-159

1 reference

Europe PubMed Central

PubMed publication ID

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22 December 2019

https://scigraph.springernature.com/pub.10.1007/s00428-006-0342-y

0 references

Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction

1 reference

https://pubmed.ncbi.nlm.nih.gov/17149612

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

AKT1/PKBalpha kinase is frequently elevated in human cancers and its constitutive activation is required for oncogenic transformation in NIH3T3 cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/17149612

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Constitutive phosphorylation of Akt/PKB protein in acute myeloid leukemia: its significance as a prognostic variable

1 reference

https://pubmed.ncbi.nlm.nih.gov/17149612

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mitogen-activated protein kinases (MAPK) as predictors of clinical outcome in serous ovarian carcinoma in effusions

1 reference

https://pubmed.ncbi.nlm.nih.gov/17149612

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mitogen-activated protein kinase pathways

1 reference

https://pubmed.ncbi.nlm.nih.gov/17149612

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phosphorylation of Akt/PKB is required for suppression of cancer cell apoptosis and tumor progression in human colorectal carcinoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/17149612

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tissue microarray (TMA) technology: miniaturized pathology archives for high-throughput in situ studies

1 reference

https://pubmed.ncbi.nlm.nih.gov/17149612

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

AKT/PKB and other D3 phosphoinositide-regulated kinases: kinase activation by phosphoinositide-dependent phosphorylation

1 reference

https://pubmed.ncbi.nlm.nih.gov/17149612

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Multicenter phase II study of the oral MEK inhibitor, CI-1040, in patients with advanced non-small-cell lung, breast, colon, and pancreatic cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/17149612

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

PI3K: downstream AKTion blocks apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/17149612

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Signal transduction via the MAP kinases: proceed at your own RSK.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17149612

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

PKB/Akt mediates cell-cycle progression by phosphorylation of p27(Kip1) at threonine 157 and modulation of its cellular localization

1 reference

https://pubmed.ncbi.nlm.nih.gov/17149612

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular alterations of the AKT2 oncogene in ovarian and breast carcinomas

1 reference

https://pubmed.ncbi.nlm.nih.gov/17149612

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Constitutive activation of the 41-/43-kDa mitogen-activated protein kinase signaling pathway in human tumors

1 reference

https://pubmed.ncbi.nlm.nih.gov/17149612

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Adjuvant 5-fluorouracil and leucovorin with or without interferon alfa-2a in colon carcinoma: National Surgical Adjuvant Breast and Bowel Project protocol C-05.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17149612

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Kirsten ras mutations in patients with colorectal cancer: the multicenter "RASCAL" study.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17149612

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prognostic significance of activated Akt expression in melanoma: a clinicopathologic study of 292 cases

1 reference

https://pubmed.ncbi.nlm.nih.gov/17149612

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mitogen-activated protein kinases: specific messages from ubiquitous messengers

1 reference

https://pubmed.ncbi.nlm.nih.gov/17149612

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cyclin D1 expression is regulated positively by the p42/p44MAPK and negatively by the p38/HOGMAPK pathway.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17149612

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Involvement of the PI 3-kinase signaling pathway in progression of colon adenocarcinoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/17149612

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Epidermal growth factor induces c-fos and c-jun mRNA via Raf-1/MEK1/ERK-dependent and -independent pathways in bovine luteal cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/17149612

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The prognostic significance of K-ras, p53, and APC mutations in colorectal carcinoma.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17149612

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ceramide regulates the transcription of cyclooxygenase-2. Evidence for involvement of extracellular signal-regulated kinase/c-Jun N-terminal kinase and p38 mitogen-activated protein kinase pathways

1 reference

https://pubmed.ncbi.nlm.nih.gov/17149612

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Colorectal tumors frequently express phosphorylated mitogen-activated protein kinase

1 reference

https://pubmed.ncbi.nlm.nih.gov/17149612

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cellular survival: a play in three Akts

1 reference

https://pubmed.ncbi.nlm.nih.gov/17149612

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The MAPK signalling pathways and colorectal cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/17149612

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Development of anticancer drugs targeting the MAP kinase pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/17149612

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase

1 reference

https://pubmed.ncbi.nlm.nih.gov/17149612

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Targeting the mitogen-activated protein kinase cascade to treat cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/17149612

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Infrequent activation of mitogen-activated protein kinase in human colon cancers.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17149612

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prognostic relevance of activated Akt kinase in node-negative breast cancer: a clinicopathological study of 99 cases

1 reference

https://pubmed.ncbi.nlm.nih.gov/17149612

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of cell death protease caspase-9 by phosphorylation

1 reference

https://pubmed.ncbi.nlm.nih.gov/17149612

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glycogen synthase kinase-3beta regulates cyclin D1 proteolysis and subcellular localization

1 reference

https://pubmed.ncbi.nlm.nih.gov/17149612

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cloning of bovine GAP and its interaction with oncogenic ras p21.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17149612

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Akt2 expression correlates with prognosis of human hepatocellular carcinoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/17149612

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression and prognostic relevance of activated extracellular-regulated kinases (ERK1/2) in breast cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/17149612

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Retinoic acid induced mitogen-activated protein (MAP)/extracellular signal-regulated kinase (ERK) kinase-dependent MAP kinase activation needed to elicit HL-60 cell differentiation and growth arrest.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17149612

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Extra-cellular signal-regulated ERK-1/ERK-2 pathway activation in human salivary gland mucoepidermoid carcinoma: association to aggressive tumor behavior and tumor cell proliferation

1 reference

https://pubmed.ncbi.nlm.nih.gov/17149612

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The Measurement of Observer Agreement for Categorical Data

1 reference

https://pubmed.ncbi.nlm.nih.gov/17149612

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cytoplasmic localization of p21Cip1/WAF1 by Akt-induced phosphorylation in HER-2/neu-overexpressing cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/17149612

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Genetic alterations during colorectal-tumor development

1 reference

https://pubmed.ncbi.nlm.nih.gov/17149612

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mitogen-activated protein (MAP) kinase pathways: regulation and physiological functions

1 reference

https://pubmed.ncbi.nlm.nih.gov/17149612

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prognostic significance of activated Akt expression in pancreatic ductal adenocarcinoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/17149612

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1007/S00428-006-0342-Y

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17149612%20AND%20SRC:MED&resulttype=core&format=json

22 December 2019

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17149612%20AND%20SRC:MED&resulttype=core&format=json

22 December 2019

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