Wikidata

(Q7941454)

English

Von Hippel-Lindau tumor suppressor

mammalian protein found in Homo sapiens

  • elongin binding protein
  • von Hippel-Lindau disease tumor suppressor
  • pVHL
  • von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase
  • VHL
  • protein G7
  • Von Hippel-Lindau Tumor Suppressor Protein
In more languages

Statements

molecular function
protein binding
determination method
IPI
28 references
retrieved
8 April 2019
stated in
Ubiquitination of a novel deubiquitinating enzyme requires direct binding to von Hippel-Lindau tumor suppressor protein
GOA
curator
UniProt
UniProt protein ID
P40337
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40337
determination method
IPI
retrieved
8 April 2019
stated in
FIH-1: a novel protein that interacts with HIF-1alpha and VHL to mediate repression of HIF-1 transcriptional activity
GOA
curator
UniProt
UniProt protein ID
P40337
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40337
determination method
IPI
retrieved
8 April 2019
stated in
The von Hippel-Lindau tumor suppressor stabilizes novel plant homeodomain protein Jade-1
GOA
curator
UniProt
UniProt protein ID
P40337
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40337
determination method
IPI
retrieved
8 April 2019
stated in
Oxygen-regulated beta(2)-adrenergic receptor hydroxylation by EGLN3 and ubiquitylation by pVHL
GOA
curator
UniProt
UniProt protein ID
P40337
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40337
determination method
IPI
retrieved
8 April 2019
stated in
Erythroid-specific 5-aminolevulinate synthase protein is stabilized by low oxygen and proteasomal inhibition
GOA
curator
UniProt
UniProt protein ID
P40337
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40337
determination method
IPI
retrieved
8 April 2019
stated in
The LIMD1 protein bridges an association between the prolyl hydroxylases and VHL to repress HIF-1 activity
GOA
curator
UniProt
UniProt protein ID
P40337
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40337
determination method
IPI
retrieved
8 April 2019
stated in
Erythrocytosis-associated HIF-2alpha mutations demonstrate a critical role for residues C-terminal to the hydroxylacceptor proline
GOA
curator
UniProt
UniProt protein ID
P40337
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40337
determination method
IPI
retrieved
8 April 2019
stated in
The TRC8 hereditary kidney cancer gene suppresses growth and functions with VHL in a common pathway
GOA
curator
UniProt
UniProt protein ID
P40337
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40337
determination method
IPI
retrieved
8 April 2019
stated in
Regulation of the VHL/HIF-1 pathway by DJ-1
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40337
determination method
IPI
retrieved
8 April 2019
stated in
NEDD8 acts as a 'molecular switch' defining the functional selectivity of VHL
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40337
determination method
IPI
retrieved
8 April 2019
stated in
OS-9 interacts with hypoxia-inducible factor 1alpha and prolyl hydroxylases to promote oxygen-dependent degradation of HIF-1alpha
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40337
determination method
IPI
retrieved
8 April 2019
stated in
The peptidyl prolyl cis/trans isomerase FKBP38 determines hypoxia-inducible transcription factor prolyl-4-hydroxylase PHD2 protein stability
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40337
determination method
IPI
retrieved
8 April 2019
stated in
Insights into Cullin-RING E3 ubiquitin ligase recruitment: structure of the VHL-EloBC-Cul2 complex
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40337
determination method
IPI
retrieved
8 April 2019
stated in
Structure of an HIF-1alpha -pVHL complex: hydroxyproline recognition in signaling
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40337
determination method
IPI
retrieved
8 April 2019
stated in
Structural basis for the recognition of hydroxyproline in HIF-1 alpha by pVHL
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40337
determination method
IPI
retrieved
8 April 2019
stated in
Loss of Mel-18 induces tumor angiogenesis through enhancing the activity and expression of HIF-1α mediated by the PTEN/PI3K/Akt pathway
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40337
determination method
IPI
retrieved
8 April 2019
stated in
Hypoxia and cell cycle regulation of the von Hippel-Lindau tumor suppressor
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40337
determination method
IPI
retrieved
8 April 2019
stated in
A proteome-scale map of the human interactome network
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40337
determination method
IPI
retrieved
8 April 2019
stated in
HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40337
determination method
IPI
retrieved
8 April 2019
stated in
Hypoxia regulates Hippo signalling through the SIAH2 ubiquitin E3 ligase
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40337
determination method
IPI
retrieved
8 April 2019
stated in
Cancer cells promote survival through depletion of the von Hippel-Lindau tumor suppressor by protein crosslinking
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40337
determination method
IPI
retrieved
8 April 2019
stated in
PKCzetaII is a target for degradation through the tumour suppressor protein pVHL
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40337
determination method
IPI
retrieved
8 April 2019
stated in
Metastasis-associated protein 1 enhances stability of hypoxia-inducible factor-1alpha protein by recruiting histone deacetylase 1.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40337
determination method
IPI
retrieved
8 April 2019
stated in
VHL-box and SOCS-box domains determine binding specificity for Cul2-Rbx1 and Cul5-Rbx2 modules of ubiquitin ligases
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40337
determination method
IPI
retrieved
8 April 2019
stated in
Regulation of receptor for activated C kinase 1 protein by the von Hippel-Lindau tumor suppressor in IGF-I-induced renal carcinoma cell invasiveness
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40337
determination method
IPI
retrieved
8 April 2019
stated in
A Y2H-seq approach defines the human protein methyltransferase interactome
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40337
determination method
IPI
retrieved
8 April 2019
stated in
The HILDA complex coordinates a conditional switch in the 3'-untranslated region of the VEGFA mRNA
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40337
determination method
IPI
retrieved
8 April 2019
stated in
The TRC8 hereditary kidney cancer gene suppresses growth and functions with VHL in a common pathway
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40337
determination method
IPI
cell component
biological process
Gene Atlas image
PBB GE VHL 203844 at fs.png
732 × 530; 12 KB
0 references

Identifiers

MeSH descriptor ID
D051794
subject named as
Von Hippel-Lindau Tumor Suppressor Protein
0 references
Freebase ID
/m/0fn20l
0 references
PDB structure ID
 
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