(Q79820865)

English

Haploinsufficiency of Parp1 accelerates Brca1-associated centrosome amplification, telomere shortening, genetic instability, apoptosis, and embryonic lethality

scientific article published on 23 February 2007

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scholarly article

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17318223%20AND%20SRC:MED&resulttype=core&format=json

26 December 2019

Haploinsufficiency of Parp1 accelerates Brca1-associated centrosome amplification, telomere shortening, genetic instability, apoptosis, and embryonic lethality (English)

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17318223%20AND%20SRC:MED&resulttype=core&format=json

26 December 2019

haploinsufficiency

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author name string

X Wang

1

1 reference

Europe PubMed Central

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26 December 2019

L Liu

2

1 reference

Europe PubMed Central

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26 December 2019

C Montagna

3

1 reference

Europe PubMed Central

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26 December 2019

T Ried

4

1 reference

Europe PubMed Central

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26 December 2019

C-X Deng

5

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26 December 2019

publication date

23 February 2007

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Europe PubMed Central

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26 December 2019

Cell Death & Differentiation

1 reference

Europe PubMed Central

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26 December 2019

14

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26 December 2019

5

1 reference

Europe PubMed Central

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26 December 2019

924-931

1 reference

Europe PubMed Central

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26 December 2019

https://scigraph.springernature.com/pub.10.1038/sj.cdd.4402105

0 references

Breast cancer susceptibility genes. BRCA1 and BRCA2.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402105

7 January 2021

based on heuristic

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BRCA1: cell cycle checkpoint, genetic instability, DNA damage response and cancer evolution

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402105

7 January 2021

based on heuristic

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Tumor formation in Brca1 conditional mutant mice

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402105

7 January 2021

based on heuristic

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Impaired meiotic DNA-damage repair and lack of crossing-over during spermatogenesis in BRCA1 full-length isoform deficient mice

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402105

7 January 2021

based on heuristic

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Multiple genetic changes are associated with mammary tumorigenesis in Brca1 conditional knockout mice

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402105

7 January 2021

based on heuristic

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Uterus hyperplasia and increased carcinogen-induced tumorigenesis in mice carrying a targeted mutation of the Chk2 phosphorylation site in Brca1

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402105

7 January 2021

based on heuristic

inferred from DOI database lookup

Centrosome amplification and a defective G2-M cell cycle checkpoint induce genetic instability in BRCA1 exon 11 isoform-deficient cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402105

7 January 2021

based on heuristic

inferred from DOI database lookup

Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402105

7 January 2021

based on heuristic

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Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402105

7 January 2021

based on heuristic

inferred from DOI database lookup

The inhibition and treatment of breast cancer with poly (ADP-ribose) polymerase (PARP-1) inhibitors

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402105

7 January 2021

based on heuristic

inferred from DOI database lookup

PARP-1 inhibitors: are they the long-sought genetically specific drugs for BRCA1/2-associated breast cancers?

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402105

7 January 2021

based on heuristic

inferred from DOI database lookup

Poly(ADP-ribosylation) and genomic stability

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402105

7 January 2021

based on heuristic

inferred from DOI database lookup

Involvement of poly(ADP-ribose) polymerase in base excision repair

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402105

7 January 2021

based on heuristic

inferred from DOI database lookup

PARP is important for genomic stability but dispensable in apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402105

7 January 2021

based on heuristic

inferred from DOI database lookup

DNA strand break-sensing molecule poly(ADP-Ribose) polymerase cooperates with p53 in telomere function, chromosome stability, and tumor suppression

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402105

7 January 2021

based on heuristic

inferred from DOI database lookup

Parp-1 deficiency causes an increase of deletion mutations and insertions/rearrangements in vivo after treatment with an alkylating agent

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402105

7 January 2021

based on heuristic

inferred from DOI database lookup

Genetic interactions between tumor suppressors Brca1 and p53 in apoptosis, cell cycle and tumorigenesis.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402105

7 January 2021

based on heuristic

inferred from DOI database lookup

ATM-Chk2-p53 activation prevents tumorigenesis at an expense of organ homeostasis upon Brca1 deficiency

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402105

7 January 2021

based on heuristic

inferred from DOI database lookup

Genetic interactions between Brca1 and Gadd45a in centrosome duplication, genetic stability, and neural tube closure

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402105

7 January 2021

based on heuristic

inferred from DOI database lookup

Conditional mutation of Brca1 in mammary epithelial cells results in blunted ductal morphogenesis and tumour formation.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402105

7 January 2021

based on heuristic

inferred from DOI database lookup

Mammary tumors in mice conditionally mutant for Brca1 exhibit gross genomic instability and centrosome amplification yet display a recurring distribution of genomic imbalances that is similar to human breast cancer

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402105

7 January 2021

based on heuristic

inferred from DOI database lookup

Involvement of poly(ADP-Ribose) polymerase 1 and poly(ADP-Ribosyl)ation in regulation of centrosome function

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402105

7 January 2021

based on heuristic

inferred from DOI database lookup

Functions of poly(ADP-ribose) polymerase in controlling telomere length and chromosomal stability

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402105

7 January 2021

based on heuristic

inferred from DOI database lookup

A role for Brca1 in chromosome end maintenance

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402105

7 January 2021

based on heuristic

inferred from DOI database lookup

Disruption of BRCA1 function results in telomere lengthening and increased anaphase bridge formation in immortalized cell lines

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402105

7 January 2021

based on heuristic

inferred from DOI database lookup

Normal lymphocyte development and thymic lymphoma formation in Brca1 exon-11-deficient mice

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402105

7 January 2021

based on heuristic

inferred from DOI database lookup

A requirement for breast-cancer-associated gene 1 (BRCA1) in the spindle checkpoint

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402105

7 January 2021

based on heuristic

inferred from DOI database lookup

DNA repair factors and telomere-chromosome integrity in mammalian cells.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402105

7 January 2021

based on heuristic

inferred from DOI database lookup

BRCA1 Inhibition of Telomerase Activity in Cultured Cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402105

7 January 2021

based on heuristic

inferred from DOI database lookup

TRF2 Protects Human Telomeres from End-to-End Fusions

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402105

7 January 2021

based on heuristic

inferred from DOI database lookup

Inhibition of poly (ADP-ribose) polymerase activates ATM which is required for subsequent homologous recombination repair

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402105

7 January 2021

based on heuristic

inferred from DOI database lookup

In vivo misregulation of genes involved in apoptosis, development and oxidative stress in mice lacking both functional Werner syndrome protein and poly(ADP-ribose) polymerase-1.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402105

7 January 2021

based on heuristic

inferred from DOI database lookup

Telomere length dynamics and chromosomal instability in cells derived from telomerase null mice

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402105

7 January 2021

based on heuristic

inferred from DOI database lookup

Telomere length measurements using digital fluorescence microscopy

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402105

7 January 2021

based on heuristic

inferred from DOI database lookup

Multicolour spectral karyotyping of mouse chromosomes

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402105

7 January 2021

based on heuristic

inferred from DOI database lookup

Identifiers

10.1038/SJ.CDD.4402105

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17318223%20AND%20SRC:MED&resulttype=core&format=json

26 December 2019

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17318223%20AND%20SRC:MED&resulttype=core&format=json

26 December 2019

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