(Q82846837)

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Clinical doses of amikacin provide more effective suppression of the human CFTR-G542X stop mutation than gentamicin in a transgenic CF mouse model

scientific article published on 16 March 2006

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scholarly article

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18 January 2020

Clinical doses of amikacin provide more effective suppression of the human CFTR-G542X stop mutation than gentamicin in a transgenic CF mouse model (English)

1 reference

Europe PubMed Central

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18 January 2020

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Eric Sorscher

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18 January 2020

author name string

Ming Du

1

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18 January 2020

Kim M Keeling

2

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18 January 2020

Liming Fan

3

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18 January 2020

Xiaoli Liu

4

1 reference

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18 January 2020

Timea Kovaçs

5

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18 January 2020

David M Bedwell

7

1 reference

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18 January 2020

publication date

16 March 2006

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18 January 2020

Journal of Molecular Medicine

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18 January 2020

84

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18 January 2020

7

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18 January 2020

573-582

1 reference

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18 January 2020

https://scigraph.springernature.com/pub.10.1007/s00109-006-0045-5

0 references

Aminoglycoside antibiotics mediate context-dependent suppression of termination codons in a mammalian translation system

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Effect of N-acetylcysteine on gentamicin-mediated nephropathy in rats

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Correction of CFTR malfunction and stimulation of Ca-activated Cl channels restore HCO3- secretion in cystic fibrosis bile ductular cells

1 reference

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Pharmacologic therapy for stop mutations: how much CFTR activity is enough?

1 reference

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Protection against gentamicin-induced early renal alterations (phospholipidosis and increased DNA synthesis) by coadministration of poly-L-aspartic acid

1 reference

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Aminoglycosides: nephrotoxicity

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Early effects of gentamicin, tobramycin, and amikacin on the human kidney

1 reference

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Structural origins of gentamicin antibiotic action

1 reference

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Evidence that systemic gentamicin suppresses premature stop mutations in patients with cystic fibrosis

1 reference

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Human Gene Mutation Database?A biomedical information and research resource

1 reference

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The efficiency of translation termination is determined by a synergistic interplay between upstream and downstream sequences in Saccharomyces cerevisiae.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16541275

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Polyaspartic acid prevents experimental aminoglycoside nephrotoxicity

1 reference

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Aminoglycoside-mediated suppression of nonsense mutations in late infantile neuronal ceroid lipofuscinosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/16541275

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Premature termination mutations in exon 3 of the SMN1 gene are associated with exon skipping and a relatively mild SMA phenotype.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16541275

12 December 2020

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A pilot study of the effect of gentamicin on nasal potential difference measurements in cystic fibrosis patients carrying stop mutations

1 reference

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Protection against gentamicin nephrotoxicity by daptomycin in nephrectomized rats

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Na and Cl transport across the isolated turtle colon: Parallel pathways for transmural ion movement

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Vestibular and cochlear toxicity of aminoglycosides--a review

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Gentamicin administration in Duchenne patients with premature stop codon. Preliminary results

1 reference

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Deficiency of polycystin-2 reduces Ca2+ channel activity and cell proliferation in ADPKD lymphoblastoid cells

1 reference

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Five Percent of Normal Cystic Fibrosis Transmembrane Conductance Regulator mRNA Ameliorates the Severity of Pulmonary Disease in Cystic Fibrosis

1 reference

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Aminoglycoside antibiotics restore CFTR function by overcoming premature stop mutations

1 reference

https://pubmed.ncbi.nlm.nih.gov/16541275

12 December 2020

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Premature translation termination mutations are efficiently suppressed in a highly conserved region of yeast Ste6p, a member of the ATP-binding cassette (ABC) transporter family

1 reference

https://pubmed.ncbi.nlm.nih.gov/16541275

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Aminoglycoside antibiotics restore dystrophin function to skeletal muscles of mdx mice

1 reference

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Suppression of a CFTR premature stop mutation in a bronchial epithelial cell line

1 reference

https://pubmed.ncbi.nlm.nih.gov/16541275

12 December 2020

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Pharmacokinetics of gentamicin C(1), C(1a), and C(2) in beagles after a single intravenous dose

1 reference

https://pubmed.ncbi.nlm.nih.gov/16541275

12 December 2020

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alpha-L-iduronidase premature stop codons and potential read-through in mucopolysaccharidosis type I patients.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16541275

12 December 2020

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Gentamicin-Induced Correction of CFTR Function in Patients with Cystic Fibrosis andCFTRStop Mutations

1 reference

https://pubmed.ncbi.nlm.nih.gov/16541275

12 December 2020

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Aminoglycoside pretreatment partially restores the function of truncated V(2) vasopressin receptors found in patients with nephrogenic diabetes insipidus

1 reference

https://pubmed.ncbi.nlm.nih.gov/16541275

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Differing Effects on the Inner Ear of Three Gentamicin Compounds: GM-C1, -C2 and -C1a

1 reference

https://pubmed.ncbi.nlm.nih.gov/16541275

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Mechanism of aminoglycoside-induced lysosomal phospholipidosis: in vitro and in vivo studies with gentamicin and amikacin

1 reference

https://pubmed.ncbi.nlm.nih.gov/16541275

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Attenuation by daptomycin of gentamicin-induced experimental nephrotoxicity

1 reference

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Nephrotoxicity of the constituents of the gentamicin complex

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Aminoglycoside nephrotoxicity: do time and frequency of administration matter?

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High-expression vectors with multiple cloning sites for construction of trpE fusion genes: pATH vectors

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Pharmacokinetic dosing of aminoglycosides: a controlled trial

1 reference

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A non-sequence-specific requirement for SMN protein activity: the role of aminoglycosides in inducing elevated SMN protein levels

1 reference

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Sequence specificity of aminoglycoside-induced stop condon readthrough: potential implications for treatment of Duchenne muscular dystrophy

1 reference

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Clinically relevant aminoglycosides can suppress disease-associated premature stop mutations in the IDUA and P53 cDNAs in a mammalian translation system

1 reference

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Gentamicin-mediated suppression of Hurler syndrome stop mutations restores a low level of alpha-L-iduronidase activity and reduces lysosomal glycosaminoglycan accumulation

1 reference

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Inhibition of lysosomal phospholipases by aminoglycoside antibiotics: in vitro comparative studies

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Molecular aspects of renal handling of aminoglycosides and strategies for preventing the nephrotoxicity

1 reference

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Correction of ATM gene function by aminoglycoside-induced read-through of premature termination codons

1 reference

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Structure of a eukaryotic decoding region A-site RNA

1 reference

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Aminoglycoside suppression of a premature stop mutation in a Cftr-/- mouse carrying a human CFTR-G542X transgene.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16541275

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Melatonin protects against gentamicin-induced nephrotoxicity in rats

1 reference

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Expression of CTNS alleles: subcellular localization and aminoglycoside correction in vitro

1 reference

https://pubmed.ncbi.nlm.nih.gov/16541275

12 December 2020

based on heuristic

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