(Q83930249)

English

Pharmacokinetics and pharmacodynamics of ticagrelor in patients with stable coronary artery disease: results from the ONSET-OFFSET and RESPOND studies

scientific article published on 01 June 2012

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22515556%20AND%20SRC:MED&resulttype=core&format=json

29 January 2020

Pharmacokinetics and pharmacodynamics of ticagrelor in patients with stable coronary artery disease: results from the ONSET-OFFSET and RESPOND studies (English)

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22515556%20AND%20SRC:MED&resulttype=core&format=json

29 January 2020

coronary artery disease

1 reference

based on heuristic

inferred from title

pharmacokinetics

1 reference

based on heuristic

inferred from title

pharmacodynamics

1 reference

based on heuristic

inferred from title

9

object named as

Paul A Gurbel

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22515556%20AND%20SRC:MED&resulttype=core&format=json

29 January 2020

author name string

Steen E Husted

1

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22515556%20AND%20SRC:MED&resulttype=core&format=json

29 January 2020

Robert F Storey

2

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22515556%20AND%20SRC:MED&resulttype=core&format=json

29 January 2020

Kevin Bliden

3

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22515556%20AND%20SRC:MED&resulttype=core&format=json

29 January 2020

Udaya S Tantry

4

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22515556%20AND%20SRC:MED&resulttype=core&format=json

29 January 2020

Lene Høimark

5

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22515556%20AND%20SRC:MED&resulttype=core&format=json

29 January 2020

Kathleen Butler

6

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22515556%20AND%20SRC:MED&resulttype=core&format=json

29 January 2020

Cheryl Wei

7

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22515556%20AND%20SRC:MED&resulttype=core&format=json

29 January 2020

Renli Teng

8

1 reference

Europe PubMed Central

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29 January 2020

publication date

1 June 2012

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22515556%20AND%20SRC:MED&resulttype=core&format=json

29 January 2020

Clinical Pharmacokinetics

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22515556%20AND%20SRC:MED&resulttype=core&format=json

29 January 2020

51

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22515556%20AND%20SRC:MED&resulttype=core&format=json

29 January 2020

6

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22515556%20AND%20SRC:MED&resulttype=core&format=json

29 January 2020

397-409

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22515556%20AND%20SRC:MED&resulttype=core&format=json

29 January 2020

https://scigraph.springernature.com/pub.10.2165/11599830-000000000-00000

0 references

Pharmacokinetics, pharmacodynamics, safety and tolerability of multiple ascending doses of ticagrelor in healthy volunteers

1 reference

https://pubmed.ncbi.nlm.nih.gov/22515556

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Determination of ticagrelor and two metabolites in plasma samples by liquid chromatography and mass spectrometry

1 reference

https://pubmed.ncbi.nlm.nih.gov/22515556

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Response to ticagrelor in clopidogrel nonresponders and responders and effect of switching therapies: the RESPOND study

1 reference

https://pubmed.ncbi.nlm.nih.gov/22515556

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cytochromes P450 catalyze both steps of the major pathway of clopidogrel bioactivation, whereas paraoxonase catalyzes the formation of a minor thiol metabolite isomer.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22515556

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Safety, tolerability, and initial efficacy of AZD6140, the first reversible oral adenosine diphosphate receptor antagonist, compared with clopidogrel, in patients with non-ST-segment elevation acute coronary syndrome: primary results of the DISPERSE

1 reference

https://pubmed.ncbi.nlm.nih.gov/22515556

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ticagrelor: the first reversibly binding oral P2Y12 receptor antagonist

1 reference

https://pubmed.ncbi.nlm.nih.gov/22515556

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Absorption, distribution, metabolism, and excretion of ticagrelor in healthy subjects

1 reference

https://pubmed.ncbi.nlm.nih.gov/22515556

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Structure and stereochemistry of the active metabolite of clopidogrel

1 reference

https://pubmed.ncbi.nlm.nih.gov/22515556

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In vitro evaluation of potential drug-drug interactions with ticagrelor: cytochrome P450 reaction phenotyping, inhibition, induction, and differential kinetics.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22515556

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Transitioning patients from cangrelor to clopidogrel: pharmacodynamic evidence of a competitive effect

1 reference

https://pubmed.ncbi.nlm.nih.gov/22515556

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacodynamics, pharmacokinetics, and safety of the oral reversible P2Y12 antagonist AZD6140 with aspirin in patients with atherosclerosis: a double-blind comparison to clopidogrel with aspirin

1 reference

https://pubmed.ncbi.nlm.nih.gov/22515556

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacokinetics, pharmacodynamics, tolerability and safety of single ascending doses of ticagrelor, a reversibly binding oral P2Y(12) receptor antagonist, in healthy subjects

1 reference

https://pubmed.ncbi.nlm.nih.gov/22515556

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

From ATP to AZD6140: the discovery of an orally active reversible P2Y12 receptor antagonist for the prevention of thrombosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/22515556

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ticagrelor versus clopidogrel in patients with acute coronary syndromes

1 reference

https://pubmed.ncbi.nlm.nih.gov/22515556

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Clopidogrel for coronary stenting: response variability, drug resistance, and the effect of pretreatment platelet reactivity

1 reference

https://pubmed.ncbi.nlm.nih.gov/22515556

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Randomized double-blind assessment of the ONSET and OFFSET of the antiplatelet effects of ticagrelor versus clopidogrel in patients with stable coronary artery disease: the ONSET/OFFSET study.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22515556

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Baseline characteristics in the Avoiding Cardiovascular events through Combination therapy in Patients Living with Systolic Hypertension (ACCOMPLISH) trial: a hypertensive population at high cardiovascular risk

1 reference

https://pubmed.ncbi.nlm.nih.gov/22515556

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of platelet aggregation by AZD6140, a reversible oral P2Y12 receptor antagonist, compared with clopidogrel in patients with acute coronary syndromes

1 reference

https://pubmed.ncbi.nlm.nih.gov/22515556

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ticagrelor binds to human P2Y(12) independently from ADP but antagonizes ADP-induced receptor signaling and platelet aggregation.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22515556

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rosuvastatin and cardiovascular events in patients undergoing hemodialysis

1 reference

https://pubmed.ncbi.nlm.nih.gov/22515556

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Preclinical and clinical studies with selective reversible direct P2Y12 antagonists

1 reference

https://pubmed.ncbi.nlm.nih.gov/22515556

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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