(Q84019090)

English

Generation of a mouse model with a reversible hypomorphic cytochrome P450 reductase gene: utility for tissue-specific rescue of the reductase expression, and insights from a resultant mouse model with global suppression of P450 reductase expression

scientific article published on 07 April 2010

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scholarly article

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20375200%20AND%20SRC:MED&resulttype=core&format=json

30 January 2020

Generation of a mouse model with a reversible hypomorphic cytochrome P450 reductase gene: utility for tissue-specific rescue of the reductase expression, and insights from a resultant mouse model with global suppression of P450 reductase expression in extrahepatic tissues (English)

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20375200%20AND%20SRC:MED&resulttype=core&format=json

30 January 2020

1

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20375200%20AND%20SRC:MED&resulttype=core&format=json

30 January 2020

author name string

Xin Zhou

2

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20375200%20AND%20SRC:MED&resulttype=core&format=json

30 January 2020

Cheng Fang

3

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20375200%20AND%20SRC:MED&resulttype=core&format=json

30 January 2020

Lei Li

4

1 reference

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20375200%20AND%20SRC:MED&resulttype=core&format=json

30 January 2020

Kerri Kluetzman

5

1 reference

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20375200%20AND%20SRC:MED&resulttype=core&format=json

30 January 2020

Weizhu Yang

6

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20375200%20AND%20SRC:MED&resulttype=core&format=json

30 January 2020

Qing-Yu Zhang

7

1 reference

Europe PubMed Central

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30 January 2020

Xinxin Ding

8

1 reference

Europe PubMed Central

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30 January 2020

language of work or name

1 reference

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publication date

7 April 2010

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Europe PubMed Central

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30 January 2020

Journal of Pharmacology and Experimental Therapeutics

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Europe PubMed Central

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30 January 2020

334

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30 January 2020

1

1 reference

Europe PubMed Central

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30 January 2020

69-77

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20375200%20AND%20SRC:MED&resulttype=core&format=json

30 January 2020

Association of multiple developmental defects and embryonic lethality with loss of microsomal NADPH-cytochrome P450 oxidoreductase

1 reference

https://pubmed.ncbi.nlm.nih.gov/20375200

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inactivation of the hepatic cytochrome P450 system by conditional deletion of hepatic cytochrome P450 reductase.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20375200

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Liver-specific deletion of the NADPH-cytochrome P450 reductase gene: impact on plasma cholesterol homeostasis and the function and regulation of microsomal cytochrome P450 and heme oxygenase

1 reference

https://pubmed.ncbi.nlm.nih.gov/20375200

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of novel roles of the cytochrome p450 system in early embryogenesis: effects on vasculogenesis and retinoic Acid homeostasis

1 reference

https://pubmed.ncbi.nlm.nih.gov/20375200

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Conditional knockout of the mouse NADPH-cytochrome p450 reductase gene.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20375200

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mutant P450 oxidoreductase causes disordered steroidogenesis with and without Antley-Bixler syndrome

1 reference

https://pubmed.ncbi.nlm.nih.gov/20375200

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Congenital adrenal hyperplasia caused by mutant P450 oxidoreductase and human androgen synthesis: analytical study

1 reference

https://pubmed.ncbi.nlm.nih.gov/20375200

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Polycystic ovarian disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/20375200

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

P-450 cytochromes: structure and function

1 reference

https://pubmed.ncbi.nlm.nih.gov/20375200

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Targeted disruption of the c-src proto-oncogene leads to osteopetrosis in mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/20375200

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Induction of cytochrome P-450 isozyme 3a (P-450IIE1) in rabbit olfactory mucosa by ethanol and acetone

1 reference

https://pubmed.ncbi.nlm.nih.gov/20375200

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cytochrome P-450. Multiplicity of isoforms, substrates, and catalytic and regulatory mechanisms

1 reference

https://pubmed.ncbi.nlm.nih.gov/20375200

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Blastocyst implantation depends on maternal expression of leukaemia inhibitory factor

1 reference

https://pubmed.ncbi.nlm.nih.gov/20375200

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Targeted disruption of the MHC class II Aa gene in C57BL/6 mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/20375200

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tumour predisposition in mice heterozygous for a targeted mutation in Nf1

1 reference

https://pubmed.ncbi.nlm.nih.gov/20375200

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mechanism of prolongation of pentobarbital-induced sleeping time by empenthrin in mice.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20375200

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Intraperitoneal administration of coumarin causes tissue-selective depletion of cytochromes P450 and cytotoxicity in the olfactory mucosa

1 reference

https://pubmed.ncbi.nlm.nih.gov/20375200

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characterization of mice deficient in aromatase (ArKO) because of targeted disruption of the cyp19 gene

1 reference

https://pubmed.ncbi.nlm.nih.gov/20375200

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dual roles for glucokinase in glucose homeostasis as determined by liver and pancreatic beta cell-specific gene knock-outs using Cre recombinase

1 reference

https://pubmed.ncbi.nlm.nih.gov/20375200

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Transgenic mice with a hypomorphic NADPH-cytochrome P450 reductase gene: effects on development, reproduction, and microsomal cytochrome P450

1 reference

https://pubmed.ncbi.nlm.nih.gov/20375200

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cytochrome P450 oxidoreductase gene mutations and Antley-Bixler syndrome with abnormal genitalia and/or impaired steroidogenesis: molecular and clinical studies in 10 patients.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20375200

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In vivo mechanisms of tissue-selective drug toxicity: effects of liver-specific knockout of the NADPH-cytochrome P450 reductase gene on acetaminophen toxicity in kidney, lung, and nasal mucosa

1 reference

https://pubmed.ncbi.nlm.nih.gov/20375200

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Diversity and function of mutations in p450 oxidoreductase in patients with Antley-Bixler syndrome and disordered steroidogenesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/20375200

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cytochrome P450 oxidoreductase deficiency in three patients initially regarded as having 21-hydroxylase deficiency and/or aromatase deficiency: diagnostic value of urine steroid hormone analysis

1 reference

https://pubmed.ncbi.nlm.nih.gov/20375200

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rescue of cytochrome P450 oxidoreductase (Por) mouse mutants reveals functions in vasculogenesis, brain and limb patterning linked to retinoic acid homeostasis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20375200

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A Mouse Model with Liver-Specific Deletion and Global Suppression of the NADPH-Cytochrome P450 Reductase Gene: Characterization and Utility for in Vivo Studies of Cyclophosphamide Disposition

1 reference

https://pubmed.ncbi.nlm.nih.gov/20375200

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Determination of the role of target tissue metabolism in lung carcinogenesis using conditional cytochrome P450 reductase-null mice.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20375200

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression of constitutive androstane receptor, hepatic nuclear factor 4 alpha, and P450 oxidoreductase genes determines interindividual variability in basal expression and activity of a broad scope of xenobiotic metabolism genes in the human liver

1 reference

https://pubmed.ncbi.nlm.nih.gov/20375200

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Deletion of the NADPH-cytochrome P450 reductase gene in cardiomyocytes does not protect mice against doxorubicin-mediated acute cardiac toxicity

1 reference

https://pubmed.ncbi.nlm.nih.gov/20375200

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Sex determination in mammals--before and after the evolution of SRY.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20375200

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

An intestinal epithelium-specific cytochrome P450 (P450) reductase-knockout mouse model: direct evidence for a role of intestinal p450s in first-pass clearance of oral nifedipine

1 reference

https://pubmed.ncbi.nlm.nih.gov/20375200

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Creation and use of a cre recombinase transgenic database

1 reference

https://pubmed.ncbi.nlm.nih.gov/20375200

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cholesterol metabolism: the main pathway acting downstream of cytochrome P450 oxidoreductase in skeletal development of the limb

1 reference

https://pubmed.ncbi.nlm.nih.gov/20375200

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

High abundance of testosterone and salivary androgen-binding protein in the lateral nasal gland of male mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/20375200

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cre activity in fetal albCre mouse hepatocytes: Utility for developmental studies

1 reference

https://pubmed.ncbi.nlm.nih.gov/20375200

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of CYP2A5 in the clearance of nicotine and cotinine: insights from studies on a Cyp2a5-null mouse model

1 reference

https://pubmed.ncbi.nlm.nih.gov/20375200

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cre recombinase: the universal reagent for genome tailoring

1 reference

https://pubmed.ncbi.nlm.nih.gov/20375200

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hepatocyte-specific expression of Cre recombinase

1 reference

https://pubmed.ncbi.nlm.nih.gov/20375200

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A high-throughput screen to identify inhibitors of aromatase (CYP19)

1 reference

https://pubmed.ncbi.nlm.nih.gov/20375200

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1124/JPET.110.167411

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20375200%20AND%20SRC:MED&resulttype=core&format=json

30 January 2020

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20375200%20AND%20SRC:MED&resulttype=core&format=json

30 January 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20375200%20AND%20SRC:MED&resulttype=core&format=json

30 January 2020

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