(Q37104008)

English

An intestinal epithelium-specific cytochrome P450 (P450) reductase-knockout mouse model: direct evidence for a role of intestinal p450s in first-pass clearance of oral nifedipine

scientific article published on 04 December 2008

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

An intestinal epithelium-specific cytochrome P450 (P450) reductase-knockout mouse model: direct evidence for a role of intestinal p450s in first-pass clearance of oral nifedipine (English)

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

0 references

author name string

Qing-Yu Zhang

1

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

Cheng Fang

2

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

Jin Zhang

3

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

Deborah Dunbar

4

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

Laurence Kaminsky

5

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

Xinxin Ding

6

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

publication date

4 December 2008

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

Drug Metabolism and Disposition

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

37

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

3

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

651-657

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

Deletion of the NADPH-cytochrome P450 reductase gene in cardiomyocytes does not protect mice against doxorubicin-mediated acute cardiac toxicity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2645477

14 September 2017

Midazolam metabolism in cytochrome P450 3A knockout mice can be attributed to up-regulated CYP2C enzymes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2645477

14 September 2017

Knockout of cytochrome P450 3A yields new mouse models for understanding xenobiotic metabolism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2645477

14 September 2017

Dietary phytochemicals regulate whole-body CYP1A1 expression through an arylhydrocarbon receptor nuclear translocator-dependent system in gut.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2645477

14 September 2017

Clinical relevance of the small intestine as an organ of drug elimination: drug-fruit juice interactions.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2645477

14 September 2017

The human intestinal cytochrome P450 "pie".

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2645477

14 September 2017

Hepatic gene expression changes in mouse models with liver-specific deletion or global suppression of the NADPH-cytochrome P450 reductase gene. Mechanistic implications for the regulation of microsomal cytochrome P450 and the fatty liver phenotype

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2645477

14 September 2017

Predicting drug disposition via application of BCS: transport/absorption/ elimination interplay and development of a biopharmaceutics drug disposition classification system

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2645477

14 September 2017

Transgenic mice with a hypomorphic NADPH-cytochrome P450 reductase gene: effects on development, reproduction, and microsomal cytochrome P450

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2645477

14 September 2017

Comparison of cytochrome P450 (CYP) genes from the mouse and human genomes, including nomenclature recommendations for genes, pseudogenes and alternative-splice variants

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2645477

14 September 2017

The small intestine as a xenobiotic-metabolizing organ

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2645477

14 September 2017

Liver-specific deletion of the NADPH-cytochrome P450 reductase gene: impact on plasma cholesterol homeostasis and the function and regulation of microsomal cytochrome P450 and heme oxygenase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2645477

14 September 2017

Inactivation of the hepatic cytochrome P450 system by conditional deletion of hepatic cytochrome P450 reductase.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2645477

14 September 2017

Human extrahepatic cytochromes P450: function in xenobiotic metabolism and tissue-selective chemical toxicity in the respiratory and gastrointestinal tracts

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2645477

14 September 2017

The mucosa of the small intestine: how clinically relevant as an organ of drug metabolism?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2645477

14 September 2017

Role of metabolic enzymes and efflux transporters in the absorption of drugs from the small intestine

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2645477

14 September 2017

Enzyme-catalyzed processes of first-pass hepatic and intestinal drug extraction

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2645477

14 September 2017

Small Intestinal Cytochromes P450

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2645477

14 September 2017

Interaction of citrus juices with felodipine and nifedipine

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2645477

14 September 2017

Developmental regulation of villin gene expression in the epithelial cell lineages of mouse digestive and urogenital tracts

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2645477

29 September 2017

Determination of the role of target tissue metabolism in lung carcinogenesis using conditional cytochrome P450 reductase-null mice.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2645477

3 September 2018

Tissue-specific and inducible Cre-mediated recombination in the gut epithelium

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2645477

3 September 2018

Characterization of mouse small intestinal cytochrome P450 expression

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2645477

3 September 2018

Immunoblot analysis and immunohistochemical characterization of CYP2A expression in human olfactory mucosa

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2645477

3 September 2018

Conditional knockout of the mouse NADPH-cytochrome p450 reductase gene.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2645477

3 September 2018

Cis elements of the villin gene control expression in restricted domains of the vertical (crypt) and horizontal (duodenum, cecum) axes of the intestine.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2645477

3 September 2018

Effects of 5-fluorouracil on the drug-metabolizing enzymes of the small intestine and the consequent drug interaction with nifedipine in rats

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2645477

3 September 2018

Characterization of rat and human liver microsomal cytochrome P-450 forms involved in nifedipine oxidation, a prototype for genetic polymorphism in oxidative drug metabolism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2645477

4 December 2018

Saphenous vein puncture for blood sampling of the mouse, rat, hamster, gerbil, guinea pig, ferret and mink

1 reference

https://pubmed.ncbi.nlm.nih.gov/19056912

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of small intestinal cytochromes p450 in the bioavailability of oral nifedipine

1 reference

https://pubmed.ncbi.nlm.nih.gov/19056912

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rat small intestinal cytochromes P450 probed by warfarin metabolism

1 reference

https://pubmed.ncbi.nlm.nih.gov/19056912

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evaluation of chromatographic methods for the determination of nifedipine in human serum

1 reference

https://pubmed.ncbi.nlm.nih.gov/19056912

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A Mouse Model with Liver-Specific Deletion and Global Suppression of the NADPH-Cytochrome P450 Reductase Gene: Characterization and Utility for in Vivo Studies of Cyclophosphamide Disposition

1 reference

https://pubmed.ncbi.nlm.nih.gov/19056912

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The nifedipine-rifampin interaction. Evidence for induction of gut wall metabolism

1 reference

https://pubmed.ncbi.nlm.nih.gov/19056912

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Extrahepatic first-pass metabolism of nifedipine in the rat

1 reference

https://pubmed.ncbi.nlm.nih.gov/19056912

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Conditional deletion of cytochrome P450 oxidoreductase in the liver and gastrointestinal tract: a new model for studying the functions of the P450 system

1 reference

https://pubmed.ncbi.nlm.nih.gov/19056912

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1124/DMD.108.025429

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

ResearchGate publication ID

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