(Q84445291)

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CefR modulates transporters of beta-lactam intermediates preventing the loss of penicillins to the broth and increases cephalosporin production in Acremonium chrysogenum

scientific article published on 21 June 2011

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6 February 2020

CefR modulates transporters of beta-lactam intermediates preventing the loss of penicillins to the broth and increases cephalosporin production in Acremonium chrysogenum (English)

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6 February 2020

Acremonium chrysogenum

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Acremonium chrysogenum

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Fernando Teijeira

1

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6 February 2020

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R V Ullán

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6 February 2020

M Fernández-Aguado

3

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6 February 2020

J F Martín

4

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21 June 2011

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6 February 2020

Metabolic Engineering

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6 February 2020

13

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6 February 2020

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6 February 2020

532-543

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6 February 2020

Penicillin and cephalosporin biosynthetic genes: structure, organization, regulation, and evolution

1 reference

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The role of ABC transporters from Aspergillus nidulans in protection against cytotoxic agents and in antibiotic production.

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Molecular characterization and transcriptional analysis of a multidrug resistance gene cloned from the pristinamycin-producing organism, Streptomyces pristinaespiralis

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nirA, the pathway-specific regulatory gene of nitrate assimilation in Aspergillus nidulans, encodes a putative GAL4-type zinc finger protein and contains four introns in highly conserved regions

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Copurification and characterization of deacetoxycephalosporin C synthetase/hydroxylase from Cephalosporium acremonium

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7 January 2021

A homologue of the Aspergillus velvet gene regulates both cephalosporin C biosynthesis and hyphal fragmentation in Acremonium chrysogenum

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Industrial production of beta-lactam antibiotics

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Transcriptional regulation of multidrug efflux pumps in bacteria

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Regulation of bacterial drug export systems

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Multidrug resistance in fungi

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7 January 2021

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Gene organization and plasticity of the beta-lactam genes in different filamentous fungi

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7 January 2021

The cefG gene of Cephalosporium acremonium is linked to the cefEF gene and encodes a deacetylcephalosporin C acetyltransferase closely related to homoserine O-acetyltransferase

1 reference

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7 January 2021

Expression of the cefG gene is limiting for cephalosporin biosynthesis in Acremonium chrysogenum

1 reference

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7 January 2021

Enzymic analysis of NADPH metabolism in beta-lactam-producing Penicillium chrysogenum: presence of a mitochondrial NADPH dehydrogenase.

1 reference

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7 January 2021

Engineering of Penicillium chrysogenum for fermentative production of a novel carbamoylated cephem antibiotic precursor.

1 reference

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7 January 2021

Overproduction and purification of the Tn10-specified inner membrane tetracycline resistance protein Tet using fusions to beta-galactosidase

1 reference

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CPCR1, but not its interacting transcription factor AcFKH1, controls fungal arthrospore formation in Acremonium chrysogenum.

1 reference

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7 January 2021

Glucose dependent transcriptional expression of the cre1 gene in Acremonium chrysogenum strains showing different levels of cephalosporin C production

1 reference

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7 January 2021

Cytosolic NADPH metabolism in penicillin-G producing and non-producing chemostat cultures of Penicillium chrysogenum

1 reference

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7 January 2021

Recent advances in the structure and function of isopenicillin N synthase

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7 January 2021

Coupling of the biosynthesis and export of the DNA gyrase inhibitor simocyclinone in Streptomyces antibioticus.

1 reference

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7 January 2021

The last step in cephalosporin C formation revealed: crystal structures of deacetylcephalosporin C acetyltransferase from Acremonium chrysogenum in complexes with reaction intermediates

1 reference

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7 January 2021

A fungal family of transcriptional regulators: the zinc cluster proteins

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Secretion systems for secondary metabolites: how producer cells send out messages of intercellular communication

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7 January 2021

Unraveling the methionine-cephalosporin puzzle in Acremonium chrysogenum

1 reference

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7 January 2021

Organization and expression of genes involved in the biosynthesis of antibiotics and other secondary metabolites

1 reference

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7 January 2021

Regulation and compartmentalization of β-lactam biosynthesis.

1 reference

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7 January 2021

A metabolome study of the steady-state relation between central metabolism, amino acid biosynthesis and penicillin production in Penicillium chrysogenum

1 reference

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7 January 2021

Natural functions of bacterial multidrug transporters

1 reference

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7 January 2021

Expression of the transporter encoded by the cefT gene of Acremonium chrysogenum increases cephalosporin production in Penicillium chrysogenum.

1 reference

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7 January 2021

Improving production of bioactive secondary metabolites in actinomycetes by metabolic engineering

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Secondary metabolism in fungi: does chromosomal location matter?

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Rad52 multimerization is important for its nuclear localization in Saccharomyces cerevisiae

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Transformation of Aspergillus based on the hygromycin B resistance marker from Escherichia coli.

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7 January 2021

Molecular properties of bacterial multidrug transporters

1 reference

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7 January 2021

Isolation, sequence determination and expression in Escherichia coli of the isopenicillin N synthetase gene from Cephalosporium acremonium

1 reference

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7 January 2021

AcFKH1, a novel member of the forkhead family, associates with the RFX transcription factor CPCR1 in the cephalosporin C-producing fungus Acremonium chrysogenum

1 reference

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7 January 2021

Functional analysis of promoter sequences of cephalosporin C biosynthesis genes from Acremonium chrysogenum: specific DNA-protein interactions and characterization of the transcription factor PACC.

1 reference

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7 January 2021

The fungal CPCR1 protein, which binds specifically to beta-lactam biosynthesis genes, is related to human regulatory factor X transcription factors

1 reference

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7 January 2021

Proteins of the penicillin biosynthesis pathway

1 reference

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Transcription factors in fungi.

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The transporter CefM involved in translocation of biosynthetic intermediates is essential for cephalosporin production.

1 reference

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Deacetylcephalosporin C production in Penicillium chrysogenum by expression of the isopenicillin N epimerization, ring expansion, and acetylation genes

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A novel epimerization system in fungal secondary metabolism involved in the conversion of isopenicillin N into penicillin N in Acremonium chrysogenum.

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Expression of cefD2 and the conversion of isopenicillin N into penicillin N by the two-component epimerase system are rate-limiting steps in cephalosporin biosynthesis

1 reference

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RNA-silencing in Penicillium chrysogenum and Acremonium chrysogenum: validation studies using beta-lactam genes expression

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The cefT gene of Acremonium chrysogenum C10 encodes a putative multidrug efflux pump protein that significantly increases cephalosporin C production

1 reference

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Characterization of a novel peroxisome membrane protein essential for conversion of isopenicillin N into cephalosporin C.

1 reference

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Expression of the Acremonium chrysogenum cefT gene in Penicillum chrysogenum indicates that it encodes an hydrophilic beta-lactam transporter.

1 reference

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Compartmentalization and transport in beta-lactam antibiotic biosynthesis by filamentous fungi

1 reference

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Cloning and characterization of the gene cahB encoding a cephalosporin C acetylhydrolase from Acremonium chrysogenum.

1 reference

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7 January 2021

Exogenous methionine increases levels of mRNAs transcribed from pcbAB, pcbC, and cefEF genes, encoding enzymes of the cephalosporin biosynthetic pathway, in Acremonium chrysogenum

1 reference

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7 January 2021

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10.1016/J.YMBEN.2011.06.004

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21704721%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21704721%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

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