(Q84567874)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21766240%20AND%20SRC:MED&resulttype=core&format=json

7 February 2020

title

Active site similarity between human and Plasmodium falciparum phosphodiesterases: considerations for antimalarial drug design (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21766240%20AND%20SRC:MED&resulttype=core&format=json

7 February 2020

main subject

Plasmodium falciparum

1 reference

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21766240%20AND%20SRC:MED&resulttype=core&format=json

7 February 2020

David T Manallack

series ordinal

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21766240%20AND%20SRC:MED&resulttype=core&format=json

7 February 2020

author name string

Brittany L Howard

series ordinal

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21766240%20AND%20SRC:MED&resulttype=core&format=json

7 February 2020

publication date

16 July 2011

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21766240%20AND%20SRC:MED&resulttype=core&format=json

Journal of Computer - Aided Molecular Design

7 February 2020

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21766240%20AND%20SRC:MED&resulttype=core&format=json

7 February 2020

volume

25

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21766240%20AND%20SRC:MED&resulttype=core&format=json

7 February 2020

issue

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21766240%20AND%20SRC:MED&resulttype=core&format=json

7 February 2020

page(s)

753-762

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21766240%20AND%20SRC:MED&resulttype=core&format=json

https://scigraph.springernature.com/pub.10.1007/s10822-011-9458-5

7 February 2020

exact match

0 references

cites work

The Plasmodium falciparum sexual development transcriptome: a microarray analysis using ontology-based pattern identification

1 reference

12 December 2020

Gametogenesis in malaria parasites is mediated by the cGMP-dependent protein kinase

1 reference

12 December 2020

The malaria parasite cyclic GMP-dependent protein kinase plays a central role in blood-stage schizogony

1 reference

12 December 2020

Discovery of a novel class of phosphodiesterase 10A inhibitors and identification of clinical candidate 2-[4-(1-methyl-4-pyridin-4-yl-1H-pyrazol-3-yl)-phenoxymethyl]-quinoline (PF-2545920) for the treatment of schizophrenia

1 reference

12 December 2020

The next generation of phosphodiesterase inhibitors: structural clues to ligand and substrate selectivity of phosphodiesterases.

1 reference

12 December 2020

Disruption of a Plasmodium falciparum cyclic nucleotide phosphodiesterase gene causes aberrant gametogenesis

1 reference

12 December 2020

MolProbity: all-atom structure validation for macromolecular crystallography

1 reference

12 December 2020

1 reference

12 December 2020

Crystal structure of the Leishmania major phosphodiesterase LmjPDEB1 and insight into the design of the parasite-selective inhibitors

1 reference

12 December 2020

That Was Then But This Is Now: Malaria Research in the Time of an Eradication Agenda

1 reference

12 December 2020

A cyclic GMP signalling module that regulates gliding motility in a malaria parasite

1 reference

12 December 2020

Structure of the catalytic domain of human phosphodiesterase 5 with bound drug molecules

1 reference

12 December 2020

The pathogenic basis of malaria

1 reference

12 December 2020

Multiple sequence alignment with the Clustal series of programs

1 reference

12 December 2020

Biochemistry and physiology of cyclic nucleotide phosphodiesterases: essential components in cyclic nucleotide signaling

1 reference

12 December 2020

Drug to Genome to Drug: Discovery of New Antiplasmodial Compounds

1 reference

12 December 2020

Comparison of adenylate cyclase and cAMP-dependent protein kinase in gametocytogenic and nongametocytogenic clones of Plasmodium falciparum

1 reference

12 December 2020

Cyclic nucleotide-specific phosphodiesterases of Plasmodium falciparum: PfPDEalpha, a non-essential cGMP-specific PDE that is an integral membrane protein.

1 reference

12 December 2020

Genome sequence of the human malaria parasite Plasmodium falciparum

1 reference

12 December 2020

Atomic structure of PDE4: insights into phosphodiesterase mechanism and specificity

1 reference

12 December 2020

Medical need, scientific opportunity and the drive for antimalarial drugs

1 reference

12 December 2020

Purine nucleotide cyclases in the malaria parasite

1 reference

12 December 2020

The discovery of potent, selective, and orally bioavailable PDE9 inhibitors as potential hypoglycemic agents.

1 reference

12 December 2020

PfPDE1, a novel cGMP-specific phosphodiesterase from the human malaria parasite Plasmodium falciparum

1 reference

12 December 2020

Cyclic nucleotide phosphodiesterase (PDE) superfamily: A new target for the development of specific therapeutic agents

1 reference

12 December 2020

Cyclic AMP and calcium interplay as second messengers in melatonin-dependent regulation of Plasmodium falciparum cell cycle.

1 reference

12 December 2020

Crystal structures of phosphodiesterases and implications on substrate specificity and inhibitor selectivity

1 reference

12 December 2020

A selective type V phosphodiesterase inhibitor, E4021, dilates porcine large coronary artery

1 reference

12 December 2020

Structural basis for the activity of drugs that inhibit phosphodiesterases

1 reference

12 December 2020

A glutamine switch mechanism for nucleotide selectivity by phosphodiesterases

1 reference

12 December 2020

Phosphodiesterase: overview of protein structures, potential therapeutic applications and recent progress in drug development

1 reference

12 December 2020

Malaria: therapy, genes and vaccines

1 reference

12 December 2020

Malaria pathogenesis: a jigsaw with an increasing number of pieces

1 reference

12 December 2020

Cyclic nucleotide phosphodiesterases: functional implications of multiple isoforms

1 reference

12 December 2020

Structural basis for the catalytic mechanism of human phosphodiesterase 9

1 reference

12 December 2020

10.1007/S10822-011-9458-5

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21766240%20AND%20SRC:MED&resulttype=core&format=json

journals/jcamd/HowardTM11

7 February 2020

DBLP publication ID

1 reference

DBLP Dataset 2021-01-02

28 January 2021

1 reference