(Q84789545)

English

Atorvastatin inhibits proliferation and apoptosis, but induces senescence in hepatic myofibroblasts and thereby attenuates hepatic fibrosis in rats

scientific article published on 13 August 2012

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scholarly article

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11 February 2020

Atorvastatin inhibits proliferation and apoptosis, but induces senescence in hepatic myofibroblasts and thereby attenuates hepatic fibrosis in rats (English)

1 reference

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11 February 2020

Robert Schierwagen

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11 February 2020

Christian Körner

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11 February 2020

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11 February 2020

Sabine D. Klein

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Sabine Klein

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11 February 2020

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Sebastian Huss

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11 February 2020

Michaela Granzow

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Michaela Granzow

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11 February 2020

Jacob Nattermann

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Jacob Nattermann

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11 February 2020

author name string

Jeremias Klösel

2

1 reference

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11 February 2020

Irela Gretchen Reza Mazar

7

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11 February 2020

Susanne Weber

8

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11 February 2020

Peter F M van den Ven

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11 February 2020

Ursula Pieper-Fürst

10

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11 February 2020

Dieter O Fürst

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11 February 2020

Frank Lammert

13

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11 February 2020

Tilman Sauerbruch

14

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11 February 2020

publication date

13 August 2012

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11 February 2020

Laboratory Investigation

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11 February 2020

92

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11 February 2020

10

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11 February 2020

1440-1450

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11 February 2020

https://scigraph.springernature.com/pub.10.1038/labinvest.2012.106

0 references

Mechanisms of hepatic fibrogenesis

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2012.106

7 January 2021

based on heuristic

inferred from DOI database lookup

Mesenchymal cells in the liver--one cell type or two?

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2012.106

7 January 2021

based on heuristic

inferred from DOI database lookup

PDGF and signal transduction in hepatic stellate cells

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2012.106

7 January 2021

based on heuristic

inferred from DOI database lookup

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2012.106

7 January 2021

based on heuristic

inferred from DOI database lookup

Modern pathogenetic concepts of liver fibrosis suggest stellate cells and TGF-beta as major players and therapeutic targets

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2012.106

7 January 2021

based on heuristic

inferred from DOI database lookup

Myofibroblast - like cells and liver fibrogenesis: Emerging concepts in a rapidly moving scenario.

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2012.106

7 January 2021

based on heuristic

inferred from DOI database lookup

Atorvastatin attenuates hepatic fibrosis in rats after bile duct ligation via decreased turnover of hepatic stellate cells

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2012.106

7 January 2021

based on heuristic

inferred from DOI database lookup

Atorvastatin lowers portal pressure in cirrhotic rats by inhibition of RhoA/Rho-kinase and activation of endothelial nitric oxide synthase

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2012.106

7 January 2021

based on heuristic

inferred from DOI database lookup

Simvastatin lowers portal pressure in patients with cirrhosis and portal hypertension: a randomized controlled trial

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2012.106

7 January 2021

based on heuristic

inferred from DOI database lookup

Post-transcriptional regulation of endothelial nitric oxide synthase mRNA stability by Rho GTPase

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2012.106

7 January 2021

based on heuristic

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3-Hydroxy-3-methylglutaryl-CoA reductase inhibitors attenuate vascular smooth muscle proliferation by preventing rho GTPase-induced down-regulation of p27(Kip1)

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2012.106

7 January 2021

based on heuristic

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Rho GTPases, statins, and nitric oxide

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2012.106

7 January 2021

based on heuristic

inferred from DOI database lookup

Hepatic fibrosis - therapeutic strategies

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2012.106

7 January 2021

based on heuristic

inferred from DOI database lookup

Senescence of activated stellate cells limits liver fibrosis

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2012.106

7 January 2021

based on heuristic

inferred from DOI database lookup

Senescence: not just for tumor suppression.

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2012.106

7 January 2021

based on heuristic

inferred from DOI database lookup

Senescence of activated stellate cells: not just early retirement

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2012.106

7 January 2021

based on heuristic

inferred from DOI database lookup

Lovastatin-induced RhoA modulation and its effect on senescence in prostate cancer cells

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2012.106

7 January 2021

based on heuristic

inferred from DOI database lookup

Protocols to detect senescence-associated beta-galactosidase (SA-betagal) activity, a biomarker of senescent cells in culture and in vivo

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2012.106

7 January 2021

based on heuristic

inferred from DOI database lookup

A biomarker that identifies senescent human cells in culture and in aging skin in vivo

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2012.106

7 January 2021

based on heuristic

inferred from DOI database lookup

Senescence-associated beta-galactosidase is lysosomal beta-galactosidase

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2012.106

7 January 2021

based on heuristic

inferred from DOI database lookup

Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2012.106

7 January 2021

based on heuristic

inferred from DOI database lookup

The essence of senescence

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2012.106

7 January 2021

based on heuristic

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Wnt/β-catenin signaling induces the aging of mesenchymal stem cells through the DNA damage response and the p53/p21 pathway

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2012.106

7 January 2021

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The growth arrest-specific gene CCN5 is deficient in human leiomyomas and inhibits the proliferation and motility of cultured human uterine smooth muscle cells

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2012.106

7 January 2021

based on heuristic

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CCN5, a novel transcriptional repressor of the transforming growth factor β signaling pathway

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2012.106

7 January 2021

based on heuristic

inferred from DOI database lookup

A pragmatic approach to the analysis of DNA histograms with a definable G1 peak

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2012.106

7 January 2021

based on heuristic

inferred from DOI database lookup

Development and evaluation of an open source Delphi-based software for morphometric quantification of liver fibrosis

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2012.106

7 January 2021

based on heuristic

inferred from DOI database lookup

Role of cannabinoid receptors in alcoholic hepatic injury: steatosis and fibrogenesis are increased in CB2 receptor-deficient mice and decreased in CB1 receptor knockouts.

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2012.106

7 January 2021

based on heuristic

inferred from DOI database lookup

Atorvastatin induces apoptosis by a caspase-9-dependent pathway: an in vitro study on activated rat hepatic stellate cells.

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2012.106

7 January 2021

based on heuristic

inferred from DOI database lookup

Role of Rho small GTP binding protein in the regulation of actin cytoskeleton in hepatic stellate cells

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2012.106

7 January 2021

based on heuristic

inferred from DOI database lookup

Effect of HMG-CoA reductase inhibitors on proliferation and protein synthesis by rat hepatic stellate cells

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2012.106

7 January 2021

based on heuristic

inferred from DOI database lookup

Adenosine induces loss of actin stress fibers and inhibits contraction in hepatic stellate cells via Rho inhibition

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2012.106

7 January 2021

based on heuristic

inferred from DOI database lookup

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