(Q84792220)

English

Behavior of monoclonal antibodies: relation between the second virial coefficient (B (2)) at low concentrations and aggregation propensity and viscosity at high concentrations

scientific article published on 19 August 2011

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scholarly article

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21853361%20AND%20SRC:MED&resulttype=core&format=json

11 February 2020

Behavior of monoclonal antibodies: relation between the second virial coefficient (B (2)) at low concentrations and aggregation propensity and viscosity at high concentrations (English)

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21853361%20AND%20SRC:MED&resulttype=core&format=json

11 February 2020

Susumu Uchiyama

5

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21853361%20AND%20SRC:MED&resulttype=core&format=json

11 February 2020

author name string

Shuntaro Saito

1

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21853361%20AND%20SRC:MED&resulttype=core&format=json

11 February 2020

Jun Hasegawa

2

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21853361%20AND%20SRC:MED&resulttype=core&format=json

11 February 2020

Naoki Kobayashi

3

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21853361%20AND%20SRC:MED&resulttype=core&format=json

11 February 2020

Naoyuki Kishi

4

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21853361%20AND%20SRC:MED&resulttype=core&format=json

11 February 2020

Kiichi Fukui

6

1 reference

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11 February 2020

publication date

19 August 2011

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21853361%20AND%20SRC:MED&resulttype=core&format=json

11 February 2020

Pharmaceutical Research

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21853361%20AND%20SRC:MED&resulttype=core&format=json

11 February 2020

29

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11 February 2020

2

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11 February 2020

397-410

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21853361%20AND%20SRC:MED&resulttype=core&format=json

11 February 2020

Ion-specific modulation of protein interactions: anion-induced, reversible oligomerization of a fusion protein

1 reference

https://pubmed.ncbi.nlm.nih.gov/21853361

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Structure-based engineering of a monoclonal antibody for improved solubility

1 reference

https://pubmed.ncbi.nlm.nih.gov/21853361

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Roles of conformational stability and colloidal stability in the aggregation of recombinant human granulocyte colony‐stimulating factor

1 reference

https://pubmed.ncbi.nlm.nih.gov/21853361

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nonequivalence of second virial coefficients from sedimentation equilibrium and static light scattering studies of protein solutions

1 reference

https://pubmed.ncbi.nlm.nih.gov/21853361

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular origins of osmotic second virial coefficients of proteins

1 reference

https://pubmed.ncbi.nlm.nih.gov/21853361

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Long- and short-range electrostatic interactions affect the rheology of highly concentrated antibody solutions

1 reference

https://pubmed.ncbi.nlm.nih.gov/21853361

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A critical evaluation of self-interaction chromatography as a predictive tool for the assessment of protein-protein interactions in protein formulation development: a case study of a therapeutic monoclonal antibody

1 reference

https://pubmed.ncbi.nlm.nih.gov/21853361

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inverse relationship of protein concentration and aggregation.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21853361

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protein interactions in undersaturated and supersaturated solutions: a study using light and x-ray scattering

1 reference

https://pubmed.ncbi.nlm.nih.gov/21853361

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Understanding and modulating opalescence and viscosity in a monoclonal antibody formulation

1 reference

https://pubmed.ncbi.nlm.nih.gov/21853361

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Quantitative characterization of weak self-association in concentrated solutions of immunoglobulin G via the measurement of sedimentation equilibrium and osmotic pressure

1 reference

https://pubmed.ncbi.nlm.nih.gov/21853361

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Challenges in the development of high protein concentration formulations

1 reference

https://pubmed.ncbi.nlm.nih.gov/21853361

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Measurement of the second osmotic virial coefficient for protein solutions exhibiting monomer-dimer equilibrium

1 reference

https://pubmed.ncbi.nlm.nih.gov/21853361

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phase separation of an IgG1 antibody solution under a low ionic strength condition

1 reference

https://pubmed.ncbi.nlm.nih.gov/21853361

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ultrasonic storage modulus as a novel parameter for analyzing protein-protein interactions in high protein concentration solutions: correlation with static and dynamic light scattering measurements

1 reference

https://pubmed.ncbi.nlm.nih.gov/21853361

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Structural properties of monoclonal antibody aggregates induced by freeze-thawing and thermal stress

1 reference

https://pubmed.ncbi.nlm.nih.gov/21853361

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Assessment of net charge and protein-protein interactions of different monoclonal antibodies

1 reference

https://pubmed.ncbi.nlm.nih.gov/21853361

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Influence of macromolecular crowding upon the stability and state of association of proteins: predictions and observations

1 reference

https://pubmed.ncbi.nlm.nih.gov/21853361

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Monoclonal antibody successes in the clinic

1 reference

https://pubmed.ncbi.nlm.nih.gov/21853361

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Strategies for the assessment of protein aggregates in pharmaceutical biotech product development

1 reference

https://pubmed.ncbi.nlm.nih.gov/21853361

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

High concentration formulations of recombinant human interleukin-1 receptor antagonist: I. Physical characterization.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21853361

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The influence of macromolecular crowding and macromolecular confinement on biochemical reactions in physiological media

1 reference

https://pubmed.ncbi.nlm.nih.gov/21853361

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Comparative effects of pH and ionic strength on protein-protein interactions, unfolding, and aggregation for IgG1 antibodies

1 reference

https://pubmed.ncbi.nlm.nih.gov/21853361

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interactions between immunoglobulin G molecules

1 reference

https://pubmed.ncbi.nlm.nih.gov/21853361

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

New methods for measuring macromolecular interactions in solution via static light scattering: basic methodology and application to nonassociating and self-associating proteins

1 reference

https://pubmed.ncbi.nlm.nih.gov/21853361

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Multichannel pipettor performance verified by measuring pathlength of reagent dispensed into a microplate

1 reference

https://pubmed.ncbi.nlm.nih.gov/21853361

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Factors affecting the viscosity in high concentration solutions of different monoclonal antibodies.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21853361

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reversible self-association increases the viscosity of a concentrated monoclonal antibody in aqueous solution

1 reference

https://pubmed.ncbi.nlm.nih.gov/21853361

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Highly concentrated monoclonal antibody solutions: direct analysis of physical structure and thermal stability

1 reference

https://pubmed.ncbi.nlm.nih.gov/21853361

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ultrasonic rheology of a monoclonal antibody (IgG2) solution: implications for physical stability of proteins in high concentration formulations

1 reference

https://pubmed.ncbi.nlm.nih.gov/21853361

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Negative second virial coefficients as predictors of protein crystal growth: evidence from sedimentation equilibrium studies that refutes the designation of those light scattering parameters as osmotic virial coefficients

1 reference

https://pubmed.ncbi.nlm.nih.gov/21853361

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increasing IgG concentration modulates the conformational heterogeneity and bonding network that influence solution properties

1 reference

https://pubmed.ncbi.nlm.nih.gov/21853361

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protein aggregation: pathways, induction factors and analysis

1 reference

https://pubmed.ncbi.nlm.nih.gov/21853361

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Correlation of protein-protein interactions as assessed by affinity chromatography with colloidal protein stability: a case study with lysozyme

1 reference

https://pubmed.ncbi.nlm.nih.gov/21853361

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Physical stability of proteins in aqueous solution: mechanism and driving forces in nonnative protein aggregation

1 reference

https://pubmed.ncbi.nlm.nih.gov/21853361

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reversible self-association of a concentrated monoclonal antibody solution mediated by Fab-Fab interaction that impacts solution viscosity

1 reference

https://pubmed.ncbi.nlm.nih.gov/21853361

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Specific interactions in high concentration antibody solutions resulting in high viscosity

1 reference

https://pubmed.ncbi.nlm.nih.gov/21853361

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1007/S11095-011-0563-X

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21853361%20AND%20SRC:MED&resulttype=core&format=json

11 February 2020

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21853361%20AND%20SRC:MED&resulttype=core&format=json

11 February 2020

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