(Q85036285)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20844554%20AND%20SRC:MED&resulttype=core&format=json

14 February 2020

title

Licensed to elongate: a molecular mechanism for MLL-based leukaemogenesis (English)

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14 February 2020

1

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14 February 2020

Erin Guest

series ordinal

3

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14 February 2020

4

Ali Shilatifard

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14 February 2020

author name string

Chengqi Lin

series ordinal

2

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14 February 2020

publication date

16 September 2010

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14 February 2020

published in

Nature Reviews Cancer

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14 February 2020

volume

10

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14 February 2020

page(s)

721-728

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14 February 2020

issue

10

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https://scigraph.springernature.com/pub.10.1038/nrc2915

14 February 2020

exact match

0 references

cites work

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31 March 2020

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Menin associates with a trithorax family histone methyltransferase complex and with the hoxc8 locus

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Leukemia proto-oncoprotein MLL forms a SET1-like histone methyltransferase complex with menin to regulate Hox gene expression

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Global analysis of H3K4 methylation defines MLL family member targets and points to a role for MLL1-mediated H3K4 methylation in the regulation of transcriptional initiation by RNA polymerase II.

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AFF4, a component of the ELL/P-TEFb elongation complex and a shared subunit of MLL chimeras, can link transcription elongation to leukemia

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HIV-1 Tat assembles a multifunctional transcription elongation complex and stably associates with the 7SK snRNP

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Epigenetic regulation of cellular memory by the Polycomb and Trithorax group proteins

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Molecular implementation and physiological roles for histone H3 lysine 4 (H3K4) methylation

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Molecular regulation of histone H3 trimethylation by COMPASS and the regulation of gene expression.

31 March 2020

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Molecular regulation of H3K4 trimethylation by ASH2L, a shared subunit of MLL complexes

31 March 2020

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Menin critically links MLL proteins with LEDGF on cancer-associated target genes

31 March 2020

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Positional cloning of the gene for multiple endocrine neoplasia-type 1

31 March 2020

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Proteolytic cleavage of MLL generates a complex of N- and C-terminal fragments that confers protein stability and subnuclear localization

31 March 2020

1 reference

Leukemia proto-oncoprotein MLL is proteolytically processed into 2 fragments with opposite transcriptional properties

31 March 2020

1 reference

The MT domain of the proto-oncoprotein MLL binds to CpG-containing DNA and discriminates against methylation

31 March 2020

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31 March 2020

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11q23 translocations split the "AT-hook" cruciform DNA-binding region and the transcriptional repression domain from the activation domain of the mixed-lineage leukemia (MLL) gene

31 March 2020

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31 March 2020

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A higher-order complex containing AF4 and ENL family proteins with P-TEFb facilitates oncogenic and physiologic MLL-dependent transcription

31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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dELL is an essential RNA polymerase II elongation factor with a general role in development

31 March 2020

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Drosophila ELL is associated with actively elongating RNA polymerase II on transcriptionally active sites in vivo

31 March 2020

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31 March 2020

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31 March 2020

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The mixed-lineage leukemia fusion partner AF4 stimulates RNA polymerase II transcriptional elongation and mediates coordinated chromatin remodeling

31 March 2020

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31 March 2020

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RNA polymerase is poised for activation across the genome

31 March 2020

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RNA polymerase stalling at developmental control genes in the Drosophila melanogaster embryo

31 March 2020

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Controlling the elongation phase of transcription with P-TEFb

31 March 2020

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hDOT1L links histone methylation to leukemogenesis

31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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H3K79 methylation profiles define murine and human MLL-AF4 leukemias

31 March 2020

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APC mutant zebrafish uncover a changing temporal requirement for wnt signaling in liver development

31 March 2020

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31 March 2020

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31 March 2020

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The APC tumor suppressor counteracts beta-catenin activation and H3K4 methylation at Wnt target genes

31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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Hoxa9 transforms primary bone marrow cells through specific collaboration with Meis1a but not Pbx1b

31 March 2020

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Poised RNA polymerase II gives pause for thought

31 March 2020

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The RNA polymerase II elongation complex

31 March 2020

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Adult patients with de novo acute myeloid leukemia and t(9; 11)(p22; q23) have a superior outcome to patients with other translocations involving band 11q23: a cancer and leukemia group B study

31 March 2020

1 reference

12 December 2020

A carboxy-terminal domain of ELL is required and sufficient for immortalization of myeloid progenitors by MLL-ELL.

1 reference

12 December 2020

MCEF, the newest member of the AF4 family of transcription factors involved in leukemia, is a positive transcription elongation factor-b-associated protein

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12 December 2020

Chromosomal abnormalities in 478 children with acute myeloid leukemia: clinical characteristics and treatment outcome in a cooperative pediatric oncology group study-POG 8821

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12 December 2020

Favorable impact of the t(9;11) in childhood acute myeloid leukemia

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12 December 2020

Identifiers

DOI

10.1038/NRC2915

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20844554%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

14 February 2020

0 references

1 reference