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English
High lipophilicity and high daily dose of oral medications are associated with significant risk for drug-induced liver injury
scientific article published on 27 May 2013
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scholarly article
1 reference
stated in
Europe PubMed Central
PubMed publication ID
23258593
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23258593%20AND%20SRC:MED&resulttype=core&format=json
retrieved
21 February 2020
title
High lipophilicity and high daily dose of oral medications are associated with significant risk for drug-induced liver injury
(English)
1 reference
stated in
Europe PubMed Central
PubMed publication ID
23258593
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23258593%20AND%20SRC:MED&resulttype=core&format=json
retrieved
21 February 2020
author
Weida Tong
series ordinal
3
object named as
Weida Tong
1 reference
stated in
Europe PubMed Central
PubMed publication ID
23258593
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23258593%20AND%20SRC:MED&resulttype=core&format=json
retrieved
21 February 2020
Jürgen Borlak
series ordinal
2
object named as
Jürgen Borlak
1 reference
stated in
Europe PubMed Central
PubMed publication ID
23258593
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23258593%20AND%20SRC:MED&resulttype=core&format=json
retrieved
21 February 2020
author name string
Minjun Chen
series ordinal
1
1 reference
stated in
Europe PubMed Central
PubMed publication ID
23258593
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23258593%20AND%20SRC:MED&resulttype=core&format=json
retrieved
21 February 2020
publication date
27 May 2013
1 reference
stated in
Europe PubMed Central
PubMed publication ID
23258593
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23258593%20AND%20SRC:MED&resulttype=core&format=json
retrieved
21 February 2020
published in
Hepatology
1 reference
stated in
Europe PubMed Central
PubMed publication ID
23258593
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23258593%20AND%20SRC:MED&resulttype=core&format=json
retrieved
21 February 2020
volume
58
1 reference
stated in
Europe PubMed Central
PubMed publication ID
23258593
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23258593%20AND%20SRC:MED&resulttype=core&format=json
retrieved
21 February 2020
issue
1
1 reference
stated in
Europe PubMed Central
PubMed publication ID
23258593
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23258593%20AND%20SRC:MED&resulttype=core&format=json
retrieved
21 February 2020
page(s)
388-396
1 reference
stated in
Europe PubMed Central
PubMed publication ID
23258593
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23258593%20AND%20SRC:MED&resulttype=core&format=json
retrieved
21 February 2020
cites work
Drug hepatotoxicity from a regulatory perspective
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FHEP.26208
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Drug-induced liver disease
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FHEP.26208
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Results of a prospective study of acute liver failure at 17 tertiary care centers in the United States
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FHEP.26208
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The role of early in vivo toxicity testing in drug discovery toxicology
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1002%2FHEP.26208
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Is toxicogenomics a more reliable and sensitive biomarker than conventional indicators from rats to predict drug-induced liver injury in humans?
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FHEP.26208
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Concordance of the toxicity of pharmaceuticals in humans and in animals
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1002%2FHEP.26208
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Back to basics for idiosyncratic drug-induced liver injury: dose and metabolism make the poison
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FHEP.26208
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Role of metabolism in drug-induced idiosyncratic hepatotoxicity
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FHEP.26208
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Relationship between daily dose of oral medications and idiosyncratic drug-induced liver injury: search for signals
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FHEP.26208
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Oral medications with significant hepatic metabolism at higher risk for hepatic adverse events
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FHEP.26208
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The influence of drug-like concepts on decision-making in medicinal chemistry
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FHEP.26208
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Lipophilicity in drug discovery
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FHEP.26208
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Physiochemical drug properties associated with in vivo toxicological outcomes
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FHEP.26208
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Pharmacological promiscuity: dependence on compound properties and target specificity in a set of recent Roche compounds
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FHEP.26208
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Defining optimum lipophilicity and molecular weight ranges for drug candidates-Molecular weight dependent lower logD limits based on permeability
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FHEP.26208
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
FDA-approved drug labeling for the study of drug-induced liver injury
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1002%2FHEP.26208
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Developing structure-activity relationships for the prediction of hepatotoxicity.
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1002%2FHEP.26208
retrieved
7 January 2021
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inferred from DOI database lookup
Combinatorial QSAR modeling of P-glycoprotein substrates
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1002%2FHEP.26208
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7 January 2021
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inferred from DOI database lookup
A decade of toxicogenomic research and its contribution to toxicological science
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FHEP.26208
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7 January 2021
based on heuristic
inferred from DOI database lookup
The liver toxicity biomarker study: phase I design and preliminary results.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FHEP.26208
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Physicochemical drug properties associated with in vivo toxicological outcomes: a review
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FHEP.26208
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Evaluations of the trans-sulfuration pathway in multiple liver toxicity studies
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FHEP.26208
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Risk factors for idiosyncratic drug-induced liver injury
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FHEP.26208
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Drug treatments for obesity: orlistat, sibutramine, and rimonabant.
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1002%2FHEP.26208
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Ibuprofen-induced hepatotoxicity in patients with chronic hepatitis C: a case series
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FHEP.26208
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
3.3 Trovafloxacin: a case study of idiosyncratic or iatrogenic liver toxicity - molecular mechanisms and lessons for pharmacotoxicity
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FHEP.26208
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Mechanisms of trovafloxacin hepatotoxicity: studies of a model cyclopropylamine-containing system
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FHEP.26208
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identifiers
DOI
10.1002/HEP.26208
1 reference
stated in
Europe PubMed Central
PubMed publication ID
23258593
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23258593%20AND%20SRC:MED&resulttype=core&format=json
retrieved
21 February 2020
PubMed publication ID
23258593
1 reference
stated in
Europe PubMed Central
PubMed publication ID
23258593
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23258593%20AND%20SRC:MED&resulttype=core&format=json
retrieved
21 February 2020
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