(Q87503251)

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Nonclinical safety assessment of recombinant human acid sphingomyelinase (rhASM) for the treatment of acid sphingomyelinase deficiency:the utility of animal models of disease in the toxicological evaluation of potential therapeutics

scientific article published on 12 July 2014

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12 March 2020

Nonclinical safety assessment of recombinant human acid sphingomyelinase (rhASM) for the treatment of acid sphingomyelinase deficiency:the utility of animal models of disease in the toxicological evaluation of potential therapeutics (English)

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12 March 2020

Beth L. Thurberg

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Beth L Thurberg

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James M Murray

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Anne Marie Thompson

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Allison Vitsky

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Michael Hawes

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Wei-Lien Chuang

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Joshua Pacheco

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Stephen Wilson

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John M McPherson

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Kenneth P Karey

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Laura Andrews

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12 July 2014

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Molecular Genetics and Metabolism

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12 March 2020

Biochemical studies in Niemann-Pick disease. I. Major sphingolipids of liver and spleen

1 reference

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7 January 2021

Type B Niemann-Pick disease: findings at chest radiography, thin-section CT, and pulmonary function testing

1 reference

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7 January 2021

Acid sphingomyelinase deficient mice: a model of types A and B Niemann-Pick disease

1 reference

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7 January 2021

Characterization of human acid sphingomyelinase purified from the media of overexpressing Chinese hamster ovary cells

1 reference

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7 January 2021

Mannose 6-phosphate receptor-mediated uptake is defective in acid sphingomyelinase-deficient macrophages: implications for Niemann-Pick disease enzyme replacement therapy

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2014.07.005

7 January 2021

Signal transduction of stress via ceramide

1 reference

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7 January 2021

Infusion of recombinant human acid sphingomyelinase into niemann-pick disease mice leads to visceral, but not neurological, correction of the pathophysiology

1 reference

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7 January 2021

Ballooned hepatocytes in steatohepatitis: the value of keratin immunohistochemistry for diagnosis

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7 January 2021

Induction of tolerance to a recombinant human enzyme, acid alpha-glucosidase, in enzyme deficient knockout mice

1 reference

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7 January 2021

Proinflammatory cytokines

1 reference

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7 January 2021

Interleukin-6 and chronic inflammation

1 reference

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Depressed heart rate variability is associated with high IL-6 blood level and decline in the blood pressure in septic patients

1 reference

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7 January 2021

The therapeutic potential of modulating the ceramide/sphingomyelin pathway

1 reference

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Sphingolipid mediators in cardiovascular cell biology and pathology

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7 January 2021

Biologically active sphingolipids in cancer pathogenesis and treatment

1 reference

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7 January 2021

Lipopolysaccharide induces disseminated endothelial apoptosis requiring ceramide generation

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2014.07.005

7 January 2021

Downregulation of the HERG (KCNH2) K(+) channel by ceramide: evidence for ubiquitin-mediated lysosomal degradation

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2014.07.005

7 January 2021

Role of membrane sphingomyelin and ceramide in platform formation for Fas-mediated apoptosis

1 reference

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7 January 2021

Raft ceramide in molecular medicine

1 reference

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7 January 2021

Sphingosine 1-phosphate (S1P) receptor subtypes S1P1 and S1P3, respectively, regulate lymphocyte recirculation and heart rate

1 reference

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7 January 2021

Mechanisms of the negative inotropic effects of sphingosine-1-phosphate on adult mouse ventricular myocytes.

1 reference

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7 January 2021

Sphingosine-1-phosphate signaling and biological activities in the cardiovascular system.

1 reference

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7 January 2021

High-density lipoproteins and their constituent, sphingosine-1-phosphate, directly protect the heart against ischemia/reperfusion injury in vivo via the S1P3 lysophospholipid receptor

1 reference

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7 January 2021

Sphingosine Mediates the Immediate Negative Inotropic Effects of Tumor Necrosis Factor-α in the Adult Mammalian Cardiac Myocyte

1 reference

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7 January 2021

Liver and skin histopathology in adults with acid sphingomyelinase deficiency (Niemann-Pick disease type B)

1 reference

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7 January 2021

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10.1016/J.YMGME.2014.07.005

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12 March 2020

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