(Q88318271)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29634944%20AND%20SRC:MED&resulttype=core&format=json

22 March 2020

title

The Immune Revolution: A Case for Priming, Not Checkpoint (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29634944%20AND%20SRC:MED&resulttype=core&format=json

22 March 2020

author name string

Robert H Vonderheide

series ordinal

1

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29634944%20AND%20SRC:MED&resulttype=core&format=json

22 March 2020

publication date

1 April 2018

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29634944%20AND%20SRC:MED&resulttype=core&format=json

22 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29634944%20AND%20SRC:MED&resulttype=core&format=json

22 March 2020

volume

33

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29634944%20AND%20SRC:MED&resulttype=core&format=json

22 March 2020

issue

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29634944%20AND%20SRC:MED&resulttype=core&format=json

22 March 2020

page(s)

563-569

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29634944%20AND%20SRC:MED&resulttype=core&format=json

The CD40 ligand. At the center of the immune universe?

22 March 2020

cites work

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Dendritic cells acquire antigen from apoptotic cells and induce class I-restricted CTLs

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Immunology. Licence to kill

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Cross-presentation, dendritic cells, tolerance and immunity

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IFNgamma and lymphocytes prevent primary tumour development and shape tumour immunogenicity

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CD40 stimulation leads to effective therapy of CD40(-) tumors through induction of strong systemic cytotoxic T lymphocyte immunity

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Synergy between chemotherapy and immunotherapy in the treatment of established murine solid tumors

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RNA-transfected CD40-activated B cells induce functional T-cell responses against viral and tumor antigen targets: implications for pediatric immunotherapy

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CD8+ tumor-infiltrating lymphocytes together with CD4+ tumor-infiltrating lymphocytes and dendritic cells improve the prognosis of patients with pancreatic adenocarcinoma

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Combined TLR and CD40 triggering induces potent CD8+ T cell expansion with variable dependence on type I IFN

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Mechanisms and functional significance of tumour-induced dendritic-cell defects

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Trp53R172H and KrasG12D cooperate to promote chromosomal instability and widely metastatic pancreatic ductal adenocarcinoma in mice

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Drug resistance by evasion of antiangiogenic targeting of VEGF signaling in late-stage pancreatic islet tumors

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CD154 gene therapy for human B-cell malignancies

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Eradication of established tumors in mice by a combination antibody-based therapy

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Prospect of targeting the CD40 pathway for cancer therapy

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Clinical activity and immune modulation in cancer patients treated with CP-870,893, a novel CD40 agonist monoclonal antibody.

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Breast cancer instructs dendritic cells to prime interleukin 13-secreting CD4+ T cells that facilitate tumor development

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Dynamics of the immune reaction to pancreatic cancer from inception to invasion

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Enhanced efficacy and reduced toxicity of multifactorial adjuvants compared with unitary adjuvants as cancer vaccines.

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Locally administered TLR7 agonists drive systemic antitumor immune responses that are enhanced by anti-CD40 immunotherapy

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CD4(+) T cells regulate pulmonary metastasis of mammary carcinomas by enhancing protumor properties of macrophages

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In situ stimulation of CD40 and Toll-like receptor 3 transforms ovarian cancer-infiltrating dendritic cells from immunosuppressive to immunostimulatory cells

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Activation of human B cells by the agonist CD40 antibody CP-870,893 and augmentation with simultaneous toll-like receptor 9 stimulation

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Immune modulation with weekly dosing of an agonist CD40 antibody in a phase I study of patients with advanced solid tumors

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12 December 2020

Suppression of antitumor immunity by stromal cells expressing fibroblast activation protein-alpha

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Cancer immunoediting: integrating immunity's roles in cancer suppression and promotion

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CD40 agonists alter tumor stroma and show efficacy against pancreatic carcinoma in mice and humans

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Development of metastatic HER2(+) breast cancer is independent of the adaptive immune system.

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12 December 2020

Interaction with FcγRIIB is critical for the agonistic activity of anti-CD40 monoclonal antibody.

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12 December 2020

Inhibitory Fcγ receptor engagement drives adjuvant and anti-tumor activities of agonistic CD40 antibodies

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12 December 2020

Expression of tumour-specific antigens underlies cancer immunoediting

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12 December 2020

Cancer exome analysis reveals a T-cell-dependent mechanism of cancer immunoediting

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12 December 2020

Chemotherapy response of spontaneous mammary tumors is independent of the adaptive immune system

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12 December 2020

Marginating dendritic cells of the tumor microenvironment cross-present tumor antigens and stably engage tumor-specific T cells

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12 December 2020

Radiotherapy increases the permissiveness of established mammary tumors to rejection by immunomodulatory antibodies

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12 December 2020

Neutralizing tumor-promoting chronic inflammation: a magic bullet?

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12 December 2020

Immune cell infiltration as an indicator of the immune microenvironment of pancreatic cancer

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12 December 2020

Inflammatory networks and immune surveillance of pancreatic carcinoma

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12 December 2020

Arginase II expressed in cancer-associated fibroblasts indicates tissue hypoxia and predicts poor outcome in patients with pancreatic cancer

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12 December 2020

Agonistic CD40 antibodies and cancer therapy

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12 December 2020

Phase I study of the CD40 agonist antibody CP-870,893 combined with carboplatin and paclitaxel in patients with advanced solid tumors

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12 December 2020

FcγRΙΙB controls the potency of agonistic anti-TNFR mAbs.

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12 December 2020

The immune network in pancreatic cancer development and progression.

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12 December 2020

A phase I study of an agonist CD40 monoclonal antibody (CP-870,893) in combination with gemcitabine in patients with advanced pancreatic ductal adenocarcinoma

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12 December 2020

Targeting CXCL12 from FAP-expressing carcinoma-associated fibroblasts synergizes with anti-PD-L1 immunotherapy in pancreatic cancer

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12 December 2020

Role of crosslinking for agonistic CD40 monoclonal antibodies as immune therapy of cancer

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12 December 2020

Localized oncolytic virotherapy overcomes systemic tumor resistance to immune checkpoint blockade immunotherapy

1 reference

12 December 2020

Locally delivered CD40 agonist antibody accumulates in secondary lymphoid organs and eradicates experimental disseminated bladder cancer.

1 reference

12 December 2020

Genomic and bioinformatic profiling of mutational neoepitopes reveals new rules to predict anticancer immunogenicity

1 reference

12 December 2020

Immune activation and a 9-year ongoing complete remission following CD40 antibody therapy and metastasectomy in a patient with metastatic melanoma

1 reference

12 December 2020

Conformation of the human immunoglobulin G2 hinge imparts superagonistic properties to immunostimulatory anticancer antibodies.

1 reference

12 December 2020

Clinical and Biological Effects of an Agonist Anti-CD40 Antibody: A Cancer Research UK Phase I Study

1 reference

12 December 2020

Induced PD-L1 expression mediates acquired resistance to agonistic anti-CD40 treatment

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12 December 2020

The Use of Anti-CD40 mAb in Cancer.

1 reference

12 December 2020

Induction of T-cell Immunity Overcomes Complete Resistance to PD-1 and CTLA-4 Blockade and Improves Survival in Pancreatic Carcinoma

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12 December 2020

Awakening the immune system with radiation: Optimal dose and fractionation

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12 December 2020

The future of immune checkpoint therapy

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12 December 2020

Exclusion of T Cells From Pancreatic Carcinomas in Mice Is Regulated by Ly6C(low) F4/80(+) Extratumoral Macrophages

1 reference

12 December 2020

Priming the pancreatic cancer tumor microenvironment for checkpoint-inhibitor immunotherapy

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12 December 2020

Classifying Cancers Based on T-cell Infiltration and PD-L1.

1 reference

12 December 2020

Role of Local Radiation Therapy in Cancer Immunotherapy

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12 December 2020

A phase 1b clinical trial of the CD40-activating antibody CP-870,893 in combination with cisplatin and pemetrexed in malignant pleural mesothelioma.

1 reference

12 December 2020

Cancer Immunotherapy with Immunomodulatory Anti-CD137 and Anti-PD-1 Monoclonal Antibodies Requires BATF3-Dependent Dendritic Cells

1 reference

12 December 2020

T Cells Engineered against a Native Antigen Can Surmount Immunologic and Physical Barriers to Treat Pancreatic Ductal Adenocarcinoma

1 reference

12 December 2020

Bruton Tyrosine Kinase-Dependent Immune Cell Cross-talk Drives Pancreas Cancer.

1 reference

12 December 2020

Genomic analyses identify molecular subtypes of pancreatic cancer

1 reference

12 December 2020

Expansion and Activation of CD103(+) Dendritic Cell Progenitors at the Tumor Site Enhances Tumor Responses to Therapeutic PD-L1 and BRAF Inhibition.

1 reference

12 December 2020

Therapeutic Activity of Agonistic, Human Anti-CD40 Monoclonal Antibodies Requires Selective FcγR Engagement

1 reference

12 December 2020

CD40 Stimulation Obviates Innate Sensors and Drives T Cell Immunity in Cancer

1 reference

12 December 2020

Critical Role for CD103(+)/CD141(+) Dendritic Cells Bearing CCR7 for Tumor Antigen Trafficking and Priming of T Cell Immunity in Melanoma

1 reference

12 December 2020

Metastatic progression is associated with dynamic changes in the local microenvironment

1 reference

12 December 2020

Agonistic CD40 mAb-Driven IL12 Reverses Resistance to Anti-PD1 in a T-cell-Rich Tumor.

1 reference

12 December 2020

Lack of immunoediting in murine pancreatic cancer reversed with neoantigen

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12 December 2020

Pembrolizumab versus Chemotherapy for PD-L1-Positive Non-Small-Cell Lung Cancer

1 reference

12 December 2020

Functions of Murine Dendritic Cells

1 reference

12 December 2020

Immune Cytolytic Activity Stratifies Molecular Subsets of Human Pancreatic Cancer

1 reference

12 December 2020

Identification of a tumor-reactive T-cell repertoire in the immune infiltrate of patients with resectable pancreatic ductal adenocarcinoma

1 reference

12 December 2020

Tumor-Residing Batf3 Dendritic Cells Are Required for Effector T Cell Trafficking and Adoptive T Cell Therapy

1 reference

12 December 2020

Mismatch repair deficiency predicts response of solid tumors to PD-1 blockade.

1 reference

12 December 2020

Serial immunomonitoring of cancer patients receiving combined antagonistic anti-CD40 and chemotherapy reveals consistent and cyclical modulation of T cell and dendritic cell parameters.

1 reference

12 December 2020

Mitotic progression following DNA damage enables pattern recognition within micronuclei.

1 reference

12 December 2020

Dissecting the Tumor Myeloid Compartment Reveals Rare Activating Antigen-Presenting Cells Critical for T Cell Immunity.

1 reference

12 December 2020

Identification of unique neoantigen qualities in long-term survivors of pancreatic cancer.

1 reference

12 December 2020

Cancer statistics, 2018.

1 reference

12 December 2020

Tumor immunity and survival as a function of alternative neopeptides in human cancer.

1 reference

12 December 2020

10.1016/J.CCELL.2018.03.008

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29634944%20AND%20SRC:MED&resulttype=core&format=json

22 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29634944%20AND%20SRC:MED&resulttype=core&format=json

22 March 2020

PubMed publication ID

29634944

1 reference