(Q88327530)

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In Vitro Comparative Study of the Inhibitory Effects of Mangiferin and Its Aglycone Norathyriol towards UDP-Glucuronosyl Transferase (UGT) Isoforms

scientific article published on 16 June 2017

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23 March 2020

In Vitro Comparative Study of the Inhibitory Effects of Mangiferin and Its Aglycone Norathyriol towards UDP-Glucuronosyl Transferase (UGT) Isoforms (English)

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23 March 2020

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Dan Sun

1

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23 March 2020

Chun-Ze Zhang

2

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23 March 2020

Rui-Xue Ran

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23 March 2020

Yun-Feng Cao

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23 March 2020

Zuo Du

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23 March 2020

Zhi-Wei Fu

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23 March 2020

Chun-Ting Huang

7

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23 March 2020

Zhen-Ying Zhao

8

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23 March 2020

Wei-Hua Zhang

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23 March 2020

Zhong-Ze Fang

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23 March 2020

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16 June 2017

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23 March 2020

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23 March 2020

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23 March 2020

6

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23 March 2020

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16 June 2017

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0 references

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12 December 2020

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Evaluation and Comparison of the Inhibition Effect of Astragaloside IV and Aglycone Cycloastragenol on Various UDP-Glucuronosyltransferase (UGT) Isoforms.

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12 December 2020

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The Inhibition of UDP-Glucuronosyltransferase (UGT) Isoforms by Praeruptorin A and B.

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12 December 2020

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Inhibition of the arachidonic acid cascade by norathyriol via blockade of cyclooxygenase and lipoxygenase activity in neutrophils

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12 December 2020

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Investigation into UDP-glucuronosyltransferase (UGT) enzyme kinetics of imidazole- and triazole-containing antifungal drugs in human liver microsomes and recombinant UGT enzymes

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Human UDP-glucuronosyltransferase (UGT)1A3 enzyme conjugates chenodeoxycholic acid in the liver

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Deglycosylation of liquiritin strongly enhances its inhibitory potential towards UDP-glucuronosyltransferase (UGT) isoforms

1 reference

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12 December 2020

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Recent insights into the biosynthesis and biological activities of natural xanthones

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12 December 2020

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Human UDP-glucuronosyltransferases: metabolism, expression, and disease

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12 December 2020

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Mangiferin attenuates methylmercury induced cytotoxicity against IMR-32, human neuroblastoma cells by the inhibition of oxidative stress and free radical scavenging potential

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Influence of route of administration on drug availability

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In vitro inhibition of UGT1A3, UGT1A4 by ursolic acid and oleanolic acid and drug-drug interaction risk prediction.

1 reference

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12 December 2020

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Application of a liquid chromatography/tandem mass spectrometry method to pharmacokinetic study of mangiferin in rats

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12 December 2020

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Pharmacokinetics of mangiferin and its metabolite-Norathyriol, Part 1: Systemic evaluation of hepatic first-pass effect in vitro and in vivo

1 reference

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12 December 2020

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Glucuronidation of amines and other xenobiotics catalyzed by expressed human UDP-glucuronosyltransferase 1A3

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12 December 2020

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Isolation of a human intestinal bacterium that transforms mangiferin to norathyriol and inducibility of the enzyme that cleaves a C-glucosyl bond

1 reference

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12 December 2020

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Structure, mechanism and engineering of plant natural product glycosyltransferases

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12 December 2020

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Roles of glucuronidation and UDP-glucuronosyltransferases in xenobiotic bioactivation reactions

1 reference

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12 December 2020

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In vitro effects of Mangifera indica and polyphenols derived on ABCB1/P-glycoprotein activity

1 reference

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12 December 2020

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Inhibition of UDP-Glucuronosyltransferase (UGT) Isoforms by Arctiin and Arctigenin.

1 reference

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12 December 2020

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Metabolism and pharmacokinetics of mangiferin in conventional rats, pseudo-germ-free rats, and streptozotocin-induced diabetic rats

1 reference

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12 December 2020

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Mangiferin and its aglycone, norathyriol, improve glucose metabolism by activation of AMP-activated protein kinase

1 reference

https://pubmed.ncbi.nlm.nih.gov/28621744

12 December 2020

based on heuristic

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UDP-glucuronosyltransferases and clinical drug-drug interactions

1 reference

https://pubmed.ncbi.nlm.nih.gov/28621744

12 December 2020

based on heuristic

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Strong Specific Inhibition of UDP-glucuronosyltransferase 2B7 by Atractylenolide I and III.

1 reference

https://pubmed.ncbi.nlm.nih.gov/28621744

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

First-pass elimination. Basic concepts and clinical consequences

1 reference

https://pubmed.ncbi.nlm.nih.gov/28621744

12 December 2020

based on heuristic

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Naturally occurring xanthones; latest investigations: isolation, structure elucidation and chemosystematic significance.

1 reference

https://pubmed.ncbi.nlm.nih.gov/28621744

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The UDP-glucuronosyltransferases: their role in drug metabolism and detoxification

1 reference

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12 December 2020

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Decreased protein kinase C activation mediates inhibitory effect of norathyriol on serotonin-mediated endothelial permeability

1 reference

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12 December 2020

based on heuristic

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High-performance liquid chromatographic method for the determination of mangiferin in rat plasma and urine

1 reference

https://pubmed.ncbi.nlm.nih.gov/28621744

12 December 2020

based on heuristic

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In vitro stereoselective inhibition of ginsenosides toward UDP-glucuronosyltransferase (UGT) isoforms.

1 reference

https://pubmed.ncbi.nlm.nih.gov/28621744

12 December 2020

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Enantioselective inhibition of carprofen towards UDP-glucuronosyltransferase (UGT) 2B7

1 reference

https://pubmed.ncbi.nlm.nih.gov/28621744

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Pharmacokinetic study of mangiferin in human plasma after oral administration

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The inhibition of UDP-glucuronosyltransferases (UGTs) by vitamin A

1 reference

https://pubmed.ncbi.nlm.nih.gov/28621744

12 December 2020

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Inhibitory effects of calf thymus DNA on metabolism activity of CYP450 enzyme in human liver microsomes

1 reference

https://pubmed.ncbi.nlm.nih.gov/28621744

12 December 2020

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Glucuronidation of nonsteroidal anti-inflammatory drugs: identifying the enzymes responsible in human liver microsomes.

1 reference

https://pubmed.ncbi.nlm.nih.gov/28621744

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based on heuristic

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Mangiferin induces apoptosis by suppressing Bcl-xL and XIAP expressions and nuclear entry of NF-κB in HL-60 cells

1 reference

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mangiferin: a possible strategy for periodontal disease to therapy.

1 reference

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inferred from PubMed ID database lookup

cDNA cloning and characterization of the human UDP glucuronosyltransferase, UGT1A3

1 reference

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12 December 2020

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Salacia oblonga extract increases glucose transporter 4-mediated glucose uptake in L6 rat myotubes: role of mangiferin

1 reference

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12 December 2020

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Comparison of inhibition capability of scutellarein and scutellarin towards important liver UDP-glucuronosyltransferase (UGT) isoforms

1 reference

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Drug-Drug Interactions Potential of Icariin and Its Intestinal Metabolites via Inhibition of Intestinal UDP-Glucuronosyltransferases

1 reference

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Mangiferin, an anti-HIV-1 agent targeting protease and effective against resistant strains.

1 reference

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Deglycosylation of puerarin and other aromatic C-glucosides by a newly isolated human intestinal bacterium.

1 reference

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12 December 2020

based on heuristic

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Differential expression of the UGT1A locus in human liver, biliary, and gastric tissue: identification of UGT1A7 and UGT1A10 transcripts in extrahepatic tissue

1 reference

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1 reference

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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1 reference

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based on heuristic

inferred from PubMed ID database lookup

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1 reference

https://pubmed.ncbi.nlm.nih.gov/28621744

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Determination of mangiferin in rat plasma by liquid-liquid extraction with UPLC-MS/MS.

1 reference

https://pubmed.ncbi.nlm.nih.gov/28621744

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Norathyriol Suppresses Skin Cancers Induced by Solar Ultraviolet Radiation by Targeting ERK Kinases

1 reference

https://pubmed.ncbi.nlm.nih.gov/28621744

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Radioprotection by mangiferin in DBAxC57BL mice: a preliminary study

1 reference

https://pubmed.ncbi.nlm.nih.gov/28621744

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Simultaneous determination of active xanthone glycosides, timosaponins and alkaloids in rat plasma after oral administration of Zi-Shen Pill extract for the pharmacokinetic study by liquid chromatography-tandem mass spectrometry

1 reference

https://pubmed.ncbi.nlm.nih.gov/28621744

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glucuronidation and the UDP-glucuronosyltransferases in health and disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/28621744

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of major xanthones and steroidal saponins in rat urine by liquid chromatography-atmospheric pressure chemical ionization mass spectrometry technology following oral administration of Rhizoma Anemarrhenae decoction

1 reference

https://pubmed.ncbi.nlm.nih.gov/28621744

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Structure-inhibition relationship of ginsenosides towards UDP-glucuronosyltransferases (UGTs).

1 reference

https://pubmed.ncbi.nlm.nih.gov/28621744

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A comprehensive review of UDP-glucuronosyltransferase and esterases for drug development

1 reference

https://pubmed.ncbi.nlm.nih.gov/28621744

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based on heuristic

inferred from PubMed ID database lookup

New insights into the risk of phthalates: Inhibition of UDP-glucuronosyltransferases.

1 reference

https://pubmed.ncbi.nlm.nih.gov/28621744

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.3390/MOLECULES22061008

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23 March 2020

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28621744%20AND%20SRC:MED&resulttype=core&format=json

23 March 2020

PubMed publication ID

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28621744%20AND%20SRC:MED&resulttype=core&format=json

23 March 2020

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