(Q89833681)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29104947%20AND%20SRC:MED&resulttype=core&format=json

8 April 2020

title

Improvements in protein production in mammalian cells from targeted metabolic engineering (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29104947%20AND%20SRC:MED&resulttype=core&format=json

8 April 2020

author name string

Anne Richelle

series ordinal

1

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29104947%20AND%20SRC:MED&resulttype=core&format=json

8 April 2020

Nathan E Lewis

series ordinal

2

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29104947%20AND%20SRC:MED&resulttype=core&format=json

8 April 2020

publication date

6 June 2017

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29104947%20AND%20SRC:MED&resulttype=core&format=json

Current Opinion in Systems Biology

8 April 2020

published in

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8 April 2020

volume

6

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8 April 2020

page(s)

1-6

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Analysis of omics data with genome-scale models of metabolism

8 April 2020

cites work

1 reference

12 December 2020

Mammalian cell protein expression for biopharmaceutical production

1 reference

12 December 2020

Metabolomics-driven approach for the improvement of Chinese hamster ovary cell growth: overexpression of malate dehydrogenase II.

1 reference

12 December 2020

Biopharmaceutical benchmarks 2014

1 reference

12 December 2020

Large scale microarray profiling and coexpression network analysis of CHO cells identifies transcriptional modules associated with growth and productivity

1 reference

12 December 2020

Comparative transcriptome analysis to unveil genes affecting recombinant protein productivity in mammalian cells

1 reference

12 December 2020

Proteomic profiling of a high-producing Chinese hamster ovary cell culture

1 reference

12 December 2020

Next-generation genome-scale models for metabolic engineering.

1 reference

12 December 2020

Comprehensive genome and epigenome characterization of CHO cells in response to evolutionary pressures and over time.

1 reference

12 December 2020

Enhancement of production of protein biopharmaceuticals by mammalian cell cultures: the metabolomics perspective

1 reference

12 December 2020

Unveiling the principle of microRNA-mediated redundancy in cellular pathway regulation

1 reference

12 December 2020

One-step generation of triple knockout CHO cell lines using CRISPR/Cas9 and fluorescent enrichment

1 reference

12 December 2020

Improving the efficiency of CHO cell line generation using glutamine synthetase gene knockout cells

1 reference

12 December 2020

Links between metabolism and apoptosis in mammalian cells: applications for anti-apoptosis engineering

1 reference

12 December 2020

Improving glucose and glutamine metabolism of human HEK 293 and Trichoplusia ni insect cells engineered to express a cytosolic pyruvate carboxylase enzyme

1 reference

12 December 2020

Identification of microRNAs specific for high producer CHO cell lines using steady-state cultivation

1 reference

12 December 2020

A Consensus Genome-scale Reconstruction of Chinese Hamster Ovary Cell Metabolism.

1 reference

12 December 2020

Engineering cell metabolism for high-density cell culture via manipulation of sugar transport

1 reference

12 December 2020

Modification of glucose and glutamine metabolism in hybridoma cells through metabolic engineering.

1 reference

12 December 2020

The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line

1 reference

12 December 2020

High level expression of tissue inhibitor of metalloproteinases in Chinese hamster ovary cells using glutamine synthetase gene amplification

1 reference

12 December 2020

Functional expression of human pyruvate carboxylase for reduced lactic acid formation of Chinese hamster ovary cells (DG44).

1 reference

12 December 2020

The emerging CHO systems biology era: harnessing the 'omics revolution for biotechnology

1 reference

12 December 2020

Genomic landscapes of Chinese hamster ovary cell lines as revealed by the Cricetulus griseus draft genome

1 reference

12 December 2020

High-antibody-producing Chinese hamster ovary cells up-regulate intracellular protein transport and glutathione synthesis

1 reference

12 December 2020

Optimizing eukaryotic cell hosts for protein production through systems biotechnology and genome-scale modeling

1 reference

12 December 2020

Cooverexpression of alanine aminotransferase 1 in Chinese hamster ovary cells overexpressing taurine transporter further stimulates metabolism and enhances product yield

1 reference

12 December 2020

Dynamic gene expression for metabolic engineering of mammalian cells in culture

1 reference

12 December 2020

Genetic engineering of hybridoma glutamine metabolism

1 reference

12 December 2020

Non-stationary 13C metabolic flux analysis of Chinese hamster ovary cells in batch culture using extracellular labeling highlights metabolic reversibility and compartmentation

1 reference

12 December 2020

CHO cells in biotechnology for production of recombinant proteins: current state and further potential

1 reference

12 December 2020

The impact of anti-apoptotic gene Bcl-2∆ expression on CHO central metabolism.

1 reference

12 December 2020

Augmenting Chinese hamster genome assembly by identifying regions of high confidence

1 reference

12 December 2020

Modulating carbohydrate-protein interactions through glycoengineering of monoclonal antibodies to impact cancer physiology

1 reference

12 December 2020

Engineered CHO cells for production of diverse, homogeneous glycoproteins.

1 reference

12 December 2020

The art of CHO cell engineering: A comprehensive retrospect and future perspectives

1 reference

12 December 2020

Regulation of Glucose Metabolism - A Perspective From Cell Bioprocessing.

1 reference

12 December 2020

Peak antibody production is associated with increased oxidative metabolism in an industrially relevant fed-batch CHO cell culture.

1 reference

12 December 2020

Down-regulation of lactate dehydrogenase-A by siRNAs for reduced lactic acid formation of Chinese hamster ovary cells producing thrombopoietin

1 reference

12 December 2020

Application of multi-omics techniques for bioprocess design and optimization in chinese hamster ovary cells

1 reference

12 December 2020

miRNAs--pathway engineering of CHO cell factories that avoids translational burdening.

1 reference

12 December 2020

Expression of carbamoyl phosphate synthetase I and ornithine transcarbamoylase genes in Chinese hamster ovary dhfr-cells decreases accumulation of ammonium ion in culture media

1 reference

12 December 2020

Expression of recombinant cytoplasmic yeast pyruvate carboxylase for the improvement of the production of human erythropoietin by recombinant BHK-21 cells

1 reference

12 December 2020

Analyzing clonal variation of monoclonal antibody-producing CHO cell lines using an in silico metabolomic platform

1 reference

12 December 2020

CRISPR/Cas9-mediated genome engineering of CHO cell factories: Application and perspectives

1 reference

12 December 2020

Engineering mammalian cells in bioprocessing - current achievements and future perspectives

1 reference

12 December 2020

Impact of temperature reduction and expression of yeast pyruvate carboxylase on hGM-CSF-producing CHO cells

1 reference

12 December 2020

Chinese hamster genome sequenced from sorted chromosomes

1 reference

12 December 2020

Mining transcriptome data for function-trait relationship of hyper productivity of recombinant antibody

1 reference

12 December 2020

Efficient production of recombinant IgG by metabolic control and co-expression with GLUT5 in a fructose-based medium

1 reference

12 December 2020

Understanding and Controlling Sialylation in a CHO Fc-Fusion Process

1 reference

12 December 2020

Engineering the supply chain for protein production/secretion in yeasts and mammalian cells.

1 reference

12 December 2020

Engineering of a mammalian cell line for reduction of lactate formation and high monoclonal antibody production

1 reference

12 December 2020

Dynamic metabolic engineering: New strategies for developing responsive cell factories

1 reference

12 December 2020

Metabolite channeling and compartmentation in the human cell line AGE1.HN determined by 13C labeling experiments and 13C metabolic flux analysis

1 reference

12 December 2020

Decreasing lactate level and increasing antibody production in Chinese Hamster Ovary cells (CHO) by reducing the expression of lactate dehydrogenase and pyruvate dehydrogenase kinases

1 reference

12 December 2020

10.1016/J.COISB.2017.05.019

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29104947%20AND%20SRC:MED&resulttype=core&format=json

8 April 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29104947%20AND%20SRC:MED&resulttype=core&format=json

8 April 2020

PubMed publication ID

29104947

1 reference