(Q38522356)

3 September 2017

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title

CRISPR/Cas9-mediated genome engineering of CHO cell factories: Application and perspectives (English)

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3 September 2017

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3

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Helene Faustrup Kildegaard

3 September 2017

Lise Marie Grav

2

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object named as

Helene Faustrup Kildegaard

series ordinal

4

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author name string

Jae Seong Lee

series ordinal

1

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3 September 2017

publication date

9 June 2015

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3 September 2017

published in

Biotechnology Journal

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3 September 2017

volume

10

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3 September 2017

issue

7

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3 September 2017

page(s)

979-994

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Maximizing productivity of CHO cell‐based fed‐batch culture using chemically defined media conditions and typical manufacturing equipment

3 September 2017

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Cas9-crRNA ribonucleoprotein complex mediates specific DNA cleavage for adaptive immunity in bacteria

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A Programmable Dual-RNA-Guided DNA Endonuclease in Adaptive Bacterial Immunity

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CRISPR interference limits horizontal gene transfer in staphylococci by targeting DNA

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The Streptococcus thermophilus CRISPR/Cas system provides immunity in Escherichia coli

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Processing-independent CRISPR RNAs limit natural transformation in Neisseria meningitidis

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Structures of Cas9 Endonucleases Reveal RNA-Mediated Conformational Activation

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CAS9 transcriptional activators for target specificity screening and paired nickases for cooperative genome engineering

21 January 2018

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Double nicking by RNA-guided CRISPR Cas9 for enhanced genome editing specificity

21 January 2018

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DNA resection in eukaryotes: deciding how to fix the break

21 January 2018

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The mechanism of double-strand DNA break repair by the nonhomologous DNA end-joining pathway

21 January 2018

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Microhomology-mediated End Joining and Homologous Recombination share the initial end resection step to repair DNA double-strand breaks in mammalian cells

21 January 2018

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Mechanism of microhomology-mediated end-joining promoted by human DNA polymerase θ

21 January 2018

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Homologous-recombination-deficient tumours are dependent on Polθ-mediated repair

21 January 2018

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Mammalian polymerase θ promotes alternative NHEJ and suppresses recombination

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Microhomology-based choice of Cas9 nuclease target sites.

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Positive genetic selection for gene disruption in mammalian cells by homologous recombination

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Targeted genome engineering in human cells with the Cas9 RNA-guided endonuclease

21 January 2018

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Accelerating genome editing in CHO cells using CRISPR Cas9 and CRISPy, a web-based target finding tool

21 January 2018

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Multiplex CRISPR/Cas9-based genome engineering from a single lentiviral vector

21 January 2018

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Multiplex genome engineering in human cells using all-in-one CRISPR/Cas9 vector system

21 January 2018

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Analysis of off-target effects of CRISPR/Cas-derived RNA-guided endonucleases and nickases.

21 January 2018

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Characterization of genomic deletion efficiency mediated by clustered regularly interspaced palindromic repeats (CRISPR)/Cas9 nuclease system in mammalian cells.

21 January 2018

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Megabase-scale deletion using CRISPR/Cas9 to generate a fully haploid human cell line

21 January 2018

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Targeted genomic rearrangements using CRISPR/Cas technology

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Genome-wide recessive genetic screening in mammalian cells with a lentiviral CRISPR-guide RNA library

21 January 2018

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21 January 2018

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Genome-Scale CRISPR-Mediated Control of Gene Repression and Activation

21 January 2018

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Genome-scale transcriptional activation by an engineered CRISPR-Cas9 complex

21 January 2018

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https://api.crossref.org/works/10.1002%2FBIOT.201500082

High-throughput screening of a CRISPR/Cas9 library for functional genomics in human cells

21 January 2018

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https://api.crossref.org/works/10.1002%2FBIOT.201500082

Efficient genome editing in zebrafish using a CRISPR-Cas system

21 January 2018

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https://api.crossref.org/works/10.1002%2FBIOT.201500082

E-CRISP: fast CRISPR target site identification

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201500082

Cationic lipid-mediated delivery of proteins enables efficient protein-based genome editing in vitro and in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201500082

High-efficiency genome editing via 2A-coupled co-expression of fluorescent proteins and zinc finger nucleases or CRISPR/Cas9 nickase pairs

21 January 2018

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https://api.crossref.org/works/10.1002%2FBIOT.201500082

High-frequency genome editing using ssDNA oligonucleotides with zinc-finger nucleases

21 January 2018

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https://api.crossref.org/works/10.1002%2FBIOT.201500082

A rapid and general assay for monitoring endogenous gene modification

21 January 2018

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One-step generation of mice carrying mutations in multiple genes by CRISPR/Cas-mediated genome engineering

21 January 2018

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https://api.crossref.org/works/10.1002%2FBIOT.201500082

Targeted genome editing in human cells with zinc finger nucleases constructed via modular assembly

21 January 2018

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Chromosomal translocations induced at specified loci in human stem cells.

21 January 2018

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https://api.crossref.org/works/10.1002%2FBIOT.201500082

Targeted chromosomal deletions in human cells using zinc finger nucleases

21 January 2018

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https://api.crossref.org/works/10.1002%2FBIOT.201500082

Targeted chromosomal duplications and inversions in the human genome using zinc finger nucleases

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201500082

A library of TAL effector nucleases spanning the human genome

21 January 2018

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https://api.crossref.org/works/10.1002%2FBIOT.201500082

High-frequency off-target mutagenesis induced by CRISPR-Cas nucleases in human cells

21 January 2018

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https://api.crossref.org/works/10.1002%2FBIOT.201500082

DNA targeting specificity of RNA-guided Cas9 nucleases

21 January 2018

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https://api.crossref.org/works/10.1002%2FBIOT.201500082

Genome-wide binding of the CRISPR endonuclease Cas9 in mammalian cells

21 January 2018

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CRISPR/Cas9 systems have off-target activity with insertions or deletions between target DNA and guide RNA sequences

21 January 2018

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https://api.crossref.org/works/10.1002%2FBIOT.201500082

Genome-wide analysis reveals characteristics of off-target sites bound by the Cas9 endonuclease.

21 January 2018

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https://api.crossref.org/works/10.1002%2FBIOT.201500082

Unbiased detection of off-target cleavage by CRISPR-Cas9 and TALENs using integrase-defective lentiviral vectors.

21 January 2018

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https://api.crossref.org/works/10.1002%2FBIOT.201500082

High-throughput profiling of off-target DNA cleavage reveals RNA-programmed Cas9 nuclease specificity

21 January 2018

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https://api.crossref.org/works/10.1002%2FBIOT.201500082

Digenome-seq: genome-wide profiling of CRISPR-Cas9 off-target effects in human cells

21 January 2018

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https://api.crossref.org/works/10.1002%2FBIOT.201500082

Genome-wide detection of DNA double-stranded breaks induced by engineered nucleases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201500082

GUIDE-seq enables genome-wide profiling of off-target cleavage by CRISPR-Cas nucleases

21 January 2018

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https://api.crossref.org/works/10.1002%2FBIOT.201500082

Improving CRISPR-Cas nuclease specificity using truncated guide RNAs

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201500082

Fusion of catalytically inactive Cas9 to FokI nuclease improves the specificity of genome modification

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201500082

Dimeric CRISPR RNA-guided FokI nucleases for highly specific genome editing

21 January 2018

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https://api.crossref.org/works/10.1002%2FBIOT.201500082

Methods in mammalian cell line engineering: from random mutagenesis to sequence-specific approaches.

21 January 2018

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CHO cells in biotechnology for production of recombinant proteins: current state and further potential

21 January 2018

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Establishment of FUT8 knockout Chinese hamster ovary cells: an ideal host cell line for producing completely defucosylated antibodies with enhanced antibody-dependent cellular cytotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201500082

Targeted gene knockout in mammalian cells by using engineered zinc-finger nucleases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201500082

BAK and BAX deletion using zinc-finger nucleases yields apoptosis-resistant CHO cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201500082

An efficient and targeted gene integration system for high-level antibody expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201500082

Construction of engineered CHO strains for high-level production of recombinant proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201500082

Generation of site-specific retargeting platform cell lines for drug discovery using phiC31 and R4 integrases

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201500082

Zinc-finger nuclease-driven targeted integration into mammalian genomes using donors with limited chromosomal homology

21 January 2018

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https://api.crossref.org/works/10.1002%2FBIOT.201500082

In vivo cleavage of transgene donors promotes nuclease-mediated targeted integration

21 January 2018

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https://api.crossref.org/works/10.1002%2FBIOT.201500082

RNA-guided editing of bacterial genomes using CRISPR-Cas systems

21 January 2018

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Multigene editing in the Escherichia coli genome via the CRISPR-Cas9 system

21 January 2018

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Genome engineering in Saccharomyces cerevisiae using CRISPR-Cas systems

21 January 2018

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Multiplex metabolic pathway engineering using CRISPR/Cas9 in Saccharomyces cerevisiae.

21 January 2018

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https://api.crossref.org/works/10.1002%2FBIOT.201500082

Rational design of highly active sgRNAs for CRISPR-Cas9-mediated gene inactivation.

21 January 2018

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https://api.crossref.org/works/10.1002%2FBIOT.201500082

Protein engineering of Cas9 for enhanced function

21 January 2018

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https://api.crossref.org/works/10.1002%2FBIOT.201500082

Surrogate reporter-based enrichment of cells containing RNA-guided Cas9 nuclease-induced mutations

21 January 2018

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https://api.crossref.org/works/10.1002%2FBIOT.201500082

Enhanced homology-directed human genome engineering by controlled timing of CRISPR/Cas9 delivery

21 January 2018

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https://api.crossref.org/works/10.1002%2FBIOT.201500082

Toward product attribute control: developments from genome sequencing

21 January 2018

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https://api.crossref.org/works/10.1002%2FBIOT.201500082

Analysis of omics data with genome-scale models of metabolism

21 January 2018

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https://api.crossref.org/works/10.1002%2FBIOT.201500082

Systems glycobiology for glycoengineering

21 January 2018

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https://api.crossref.org/works/10.1002%2FBIOT.201500082

Towards genome-scale signalling network reconstructions

21 January 2018

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https://api.crossref.org/works/10.1002%2FBIOT.201500082

A systems approach to mapping DNA damage response pathways

21 January 2018

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https://api.crossref.org/works/10.1002%2FBIOT.201500082

Quantitative and logic modelling of molecular and gene networks

21 January 2018

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https://api.crossref.org/works/10.1002%2FBIOT.201500082

The evolution of genome-scale models of cancer metabolism

21 January 2018

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https://api.crossref.org/works/10.1002%2FBIOT.201500082

21 January 2018

Identifiers

DOI

10.1002/BIOT.201500082

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3 September 2017

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