(Q90286842)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:32166339%20AND%20SRC:MED&resulttype=core&format=json

12 April 2020

title

PLCG2 protective variant p.P522R modulates tau pathology and disease progression in patients with mild cognitive impairment (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:32166339%20AND%20SRC:MED&resulttype=core&format=json

mild cognitive impairment

12 April 2020

main subject

1 reference

inferred from title

cognitive dysfunction

1 reference

56

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:32166339%20AND%20SRC:MED&resulttype=core&format=json

Alzheimer's Disease Neuroimaging Initiative

12 April 2020

34

object named as

Alzheimer’s Disease Neuroimaging Initiative (ADNI)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:32166339%20AND%20SRC:MED&resulttype=core&format=json

12 April 2020

33

Philip Scheltens

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:32166339%20AND%20SRC:MED&resulttype=core&format=json

12 April 2020

1

Luca Kleineidam

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:32166339%20AND%20SRC:MED&resulttype=core&format=json

12 April 2020

31

Natasja M van Schoor

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:32166339%20AND%20SRC:MED&resulttype=core&format=json

12 April 2020

46

Wolfgang Maier

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:32166339%20AND%20SRC:MED&resulttype=core&format=json

12 April 2020

9

Steffen Wolfsgruber

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:32166339%20AND%20SRC:MED&resulttype=core&format=json

12 April 2020

44

Frank Jessen

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:32166339%20AND%20SRC:MED&resulttype=core&format=json

12 April 2020

Steffi G. Riedel-Heller

41

object named as

Steffi Riedel-Heller

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:32166339%20AND%20SRC:MED&resulttype=core&format=json

12 April 2020

50

Michael Wagner

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:32166339%20AND%20SRC:MED&resulttype=core&format=json

12 April 2020

Jean-François Dartigues

23

object named as

Jean-François Dartigues

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:32166339%20AND%20SRC:MED&resulttype=core&format=json

12 April 2020

12

Piotr Lewczuk

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:32166339%20AND%20SRC:MED&resulttype=core&format=json

12 April 2020

author name string

Vincent Chouraki

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:32166339%20AND%20SRC:MED&resulttype=core&format=json

12 April 2020

Tomasz Próchnicki

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:32166339%20AND%20SRC:MED&resulttype=core&format=json

12 April 2020

Sven J van der Lee

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:32166339%20AND%20SRC:MED&resulttype=core&format=json

12 April 2020

Laura Madrid-Márquez

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:32166339%20AND%20SRC:MED&resulttype=core&format=json

12 April 2020

Holger Wagner-Thelen

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:32166339%20AND%20SRC:MED&resulttype=core&format=json

12 April 2020

Ilker Karaca

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:32166339%20AND%20SRC:MED&resulttype=core&format=json

12 April 2020

Leonie Weinhold

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:32166339%20AND%20SRC:MED&resulttype=core&format=json

12 April 2020

Anne Boland

10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:32166339%20AND%20SRC:MED&resulttype=core&format=json

12 April 2020

Pamela V Martino Adami

11

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:32166339%20AND%20SRC:MED&resulttype=core&format=json

12 April 2020

Julius Popp

13

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:32166339%20AND%20SRC:MED&resulttype=core&format=json

12 April 2020

Frederic Brosseron

14

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:32166339%20AND%20SRC:MED&resulttype=core&format=json

12 April 2020

Iris E Jansen

15

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:32166339%20AND%20SRC:MED&resulttype=core&format=json

12 April 2020

Marc Hulsman

16

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:32166339%20AND%20SRC:MED&resulttype=core&format=json

12 April 2020

Johannes Kornhuber

17

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:32166339%20AND%20SRC:MED&resulttype=core&format=json

12 April 2020

Oliver Peters

18

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:32166339%20AND%20SRC:MED&resulttype=core&format=json

12 April 2020

Claudine Berr

19

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:32166339%20AND%20SRC:MED&resulttype=core&format=json

12 April 2020

Reinhard Heun

20

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:32166339%20AND%20SRC:MED&resulttype=core&format=json

12 April 2020

Lutz Frölich

21

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:32166339%20AND%20SRC:MED&resulttype=core&format=json

12 April 2020

Christophe Tzourio

22

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:32166339%20AND%20SRC:MED&resulttype=core&format=json

12 April 2020

Michael Hüll

24

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:32166339%20AND%20SRC:MED&resulttype=core&format=json

12 April 2020

Ana Espinosa

25

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:32166339%20AND%20SRC:MED&resulttype=core&format=json

12 April 2020

Isabel Hernández

26

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:32166339%20AND%20SRC:MED&resulttype=core&format=json

12 April 2020

Itziar de Rojas

27

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:32166339%20AND%20SRC:MED&resulttype=core&format=json

12 April 2020

Adelina Orellana

28

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:32166339%20AND%20SRC:MED&resulttype=core&format=json

12 April 2020

Sergi Valero

29

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:32166339%20AND%20SRC:MED&resulttype=core&format=json

12 April 2020

Najada Stringa

30

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:32166339%20AND%20SRC:MED&resulttype=core&format=json

12 April 2020

Martijn Huisman

32

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:32166339%20AND%20SRC:MED&resulttype=core&format=json

12 April 2020

Eckart Rüther

35

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:32166339%20AND%20SRC:MED&resulttype=core&format=json

12 April 2020

Jean-Francois Deleuze

36

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:32166339%20AND%20SRC:MED&resulttype=core&format=json

12 April 2020

Jens Wiltfang

37

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:32166339%20AND%20SRC:MED&resulttype=core&format=json

12 April 2020

Lluis Tarraga

38

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:32166339%20AND%20SRC:MED&resulttype=core&format=json

12 April 2020

Matthias Schmid

39

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:32166339%20AND%20SRC:MED&resulttype=core&format=json

12 April 2020

Martin Scherer

40

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:32166339%20AND%20SRC:MED&resulttype=core&format=json

12 April 2020

Michael T Heneka

42

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:32166339%20AND%20SRC:MED&resulttype=core&format=json

12 April 2020

Philippe Amouyel

43

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:32166339%20AND%20SRC:MED&resulttype=core&format=json

12 April 2020

Merce Boada

45

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:32166339%20AND%20SRC:MED&resulttype=core&format=json

12 April 2020

Anja Schneider

47

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:32166339%20AND%20SRC:MED&resulttype=core&format=json

12 April 2020

Antonio González-Pérez

48

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:32166339%20AND%20SRC:MED&resulttype=core&format=json

12 April 2020

Wiesje M van der Flier

49

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:32166339%20AND%20SRC:MED&resulttype=core&format=json

12 April 2020

Jean-Charles Lambert

51

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:32166339%20AND%20SRC:MED&resulttype=core&format=json

12 April 2020

Henne Holstege

52

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:32166339%20AND%20SRC:MED&resulttype=core&format=json

12 April 2020

Mª Eugenia Sáez

53

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:32166339%20AND%20SRC:MED&resulttype=core&format=json

12 April 2020

Eicke Latz

54

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:32166339%20AND%20SRC:MED&resulttype=core&format=json

12 April 2020

Agustin Ruiz

55

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:32166339%20AND%20SRC:MED&resulttype=core&format=json

12 April 2020

publication date

12 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:32166339%20AND%20SRC:MED&resulttype=core&format=json

12 April 2020

published in

Acta Neuropathologica

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:32166339%20AND%20SRC:MED&resulttype=core&format=json

Physical basis of cognitive alterations in alzheimer's disease: Synapse loss is the major correlate of cognitive impairment

12 April 2020

cites work

1 reference

12 December 2020

Phosphatidylinositol 3-kinase, phosphoinositide-specific phospholipase-Cgamma and protein kinase-C signal myelin phagocytosis mediated by complement receptor-3 alone and combined with scavenger receptor-AI/II in macrophages

1 reference

12 December 2020

Non-PKC DAG/phorbol-ester receptor(s) inhibit complement receptor-3 and nPKC inhibit scavenger receptor-AI/II-mediated myelin phagocytosis but cPKC, PI3k, and PLCgamma activate myelin phagocytosis by both

1 reference

12 December 2020

Antigen-receptor signaling to nuclear factor kappa B.

1 reference

12 December 2020

Synapse loss and microglial activation precede tangles in a P301S tauopathy mouse model

1 reference

12 December 2020

Expression of amyloid beta peptide in human platelets: pivotal role of the phospholipase Cgamma2-protein kinase C pathway in platelet activation

1 reference

12 December 2020

Integrative data analysis: the simultaneous analysis of multiple data sets

1 reference

12 December 2020

TREM2- and DAP12-dependent activation of PI3K requires DAP10 and is inhibited by SHIP1.

1 reference

12 December 2020

Regulation of tau pathology by the microglial fractalkine receptor

1 reference

12 December 2020

Reimagining Alzheimer's disease--an age-based hypothesis

1 reference

12 December 2020

The amyloid cascade hypothesis for Alzheimer's disease: an appraisal for the development of therapeutics

1 reference

12 December 2020

Misuse of the linear mixed model when evaluating risk factors of cognitive decline

1 reference

12 December 2020

Stages of the pathologic process in Alzheimer disease: age categories from 1 to 100 years.

1 reference

12 December 2020

CD14 controls the LPS-induced endocytosis of Toll-like receptor 4

1 reference

12 December 2020

Cold urticaria, immunodeficiency, and autoimmunity related to PLCG2 deletions

1 reference

12 December 2020

GeneFriends: an online co-expression analysis tool to identify novel gene targets for aging and complex diseases.

1 reference

12 December 2020

The ADAS-Cog revisited: novel composite scales based on ADAS-Cog to improve efficiency in MCI and early AD trials

1 reference

12 December 2020

Using exome sequencing to reveal mutations in TREM2 presenting as a frontotemporal dementia-like syndrome without bone involvement

1 reference

12 December 2020

Tracking pathophysiological processes in Alzheimer's disease: an updated hypothetical model of dynamic biomarkers

1 reference

12 December 2020

Vulnerable neural systems and the borderland of brain aging and neurodegeneration

1 reference

12 December 2020

Integrated systems approach identifies genetic nodes and networks in late-onset Alzheimer's disease

1 reference

12 December 2020

Much of late life cognitive decline is not due to common neurodegenerative pathologies.

1 reference

12 December 2020

TREM2 in neurodegeneration: evidence for association of the p.R47H variant with frontotemporal dementia and Parkinson's disease

1 reference

12 December 2020

Validating therapeutic targets through human genetics

1 reference

12 December 2020

Classification and epidemiology of MCI.

1 reference

12 December 2020

Human genetics as a foundation for innovative drug development.

1 reference

12 December 2020

What is normal in normal aging? Effects of aging, amyloid and Alzheimer's disease on the cerebral cortex and the hippocampus

1 reference

12 December 2020

Connecting two pathways through Ca 2+ signaling: NLRP3 inflammasome activation induced by a hypermorphic PLCG2 mutation

1 reference

12 December 2020

Convergent genetic and expression data implicate immunity in Alzheimer's disease

1 reference

12 December 2020

A novel Alzheimer disease locus located near the gene encoding tau protein.

1 reference

12 December 2020

The role of TREM2 R47H as a risk factor for Alzheimer's disease, frontotemporal lobar degeneration, amyotrophic lateral sclerosis, and Parkinson's disease

1 reference

12 December 2020

Prevalence of cerebral amyloid pathology in persons without dementia: a meta-analysis

1 reference

12 December 2020

Prevalence of amyloid PET positivity in dementia syndromes: a meta-analysis

1 reference

12 December 2020

Colony-stimulating factor 1 receptor inhibition prevents microglial plaque association and improves cognition in 3xTg-AD mice

1 reference

12 December 2020

Depletion of microglia and inhibition of exosome synthesis halt tau propagation

1 reference

12 December 2020

Pharmacological targeting of CSF1R inhibits microglial proliferation and prevents the progression of Alzheimer's-like pathology

1 reference

12 December 2020

Eliminating microglia in Alzheimer's mice prevents neuronal loss without modulating amyloid-β pathology.

1 reference

12 December 2020

Genome-wide significant risk factors for Alzheimer's disease: role in progression to dementia due to Alzheimer's disease among subjects with mild cognitive impairment

1 reference

12 December 2020

Complement and microglia mediate early synapse loss in Alzheimer mouse models.

1 reference

12 December 2020

Alzheimer's disease cerebrospinal fluid biomarkers predict cognitive decline in lewy body dementia

1 reference

12 December 2020

TREM2 Binds to Apolipoproteins, Including APOE and CLU/APOJ, and Thereby Facilitates Uptake of Amyloid-Beta by Microglia.

1 reference

12 December 2020

Genetic architecture of sporadic frontotemporal dementia and overlap with Alzheimer's and Parkinson's diseases

1 reference

12 December 2020

Outcomes after diagnosis of mild cognitive impairment in a large autopsy series

1 reference

12 December 2020

The druggable genome and support for target identification and validation in drug development.

1 reference

12 December 2020

A Unique Microglia Type Associated with Restricting Development of Alzheimer's Disease

1 reference

12 December 2020

Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease

1 reference

12 December 2020

Evaluating Alzheimer's disease biomarkers as mediators of age-related cognitive decline.

1 reference

12 December 2020

Microglia and C9orf72 in neuroinflammation and ALS and frontotemporal dementia

1 reference

12 December 2020

TREM2 in Neurodegenerative Diseases

1 reference

12 December 2020

By Capturing Inflammatory Lipids Released from Dying Cells, the Receptor CD14 Induces Inflammasome-Dependent Phagocyte Hyperactivation

1 reference

12 December 2020

Microglia-derived ASC specks cross-seed amyloid-β in Alzheimer's disease

1 reference

12 December 2020

Humanized TREM2 mice reveal microglia-intrinsic and -extrinsic effects of R47H polymorphism.

1 reference

12 December 2020

Diverse Brain Myeloid Expression Profiles Reveal Distinct Microglial Activation States and Aspects of Alzheimer's Disease Not Evident in Mouse Models

1 reference

12 December 2020

Statistical tests and identifiability conditions for pooling and analyzing multisite datasets

1 reference

12 December 2020

Early long-term administration of the CSF1R inhibitor PLX3397 ablates microglia and reduces accumulation of intraneuronal amyloid, neuritic plaque deposition and pre-fibrillar oligomers in 5XFAD mouse model of Alzheimer's disease.

1 reference

12 December 2020

Elevated TREM2 Gene Dosage Reprograms Microglia Responsivity and Ameliorates Pathological Phenotypes in Alzheimer's Disease Models.

1 reference

12 December 2020

NIA-AA Research Framework: Toward a biological definition of Alzheimer's disease.

1 reference

12 December 2020

Prevalence and Outcomes of Amyloid Positivity Among Persons Without Dementia in a Longitudinal, Population-Based Setting.

1 reference

12 December 2020

Disease-Associated Microglia: A Universal Immune Sensor of Neurodegeneration

1 reference

12 December 2020

Cerebrospinal fluid soluble TREM2 levels in frontotemporal dementia differ by genetic and pathological subgroup

1 reference

12 December 2020

Interplay between innate immunity and Alzheimer disease: APOE and TREM2 in the spotlight

1 reference

12 December 2020

Understanding the relationship between cognition and death: a within cohort examination of cognitive measures and mortality

1 reference

12 December 2020

ABI3 and PLCG2 missense variants as risk factors for neurodegenerative diseases in Caucasians and African Americans

1 reference

12 December 2020

CSF soluble TREM2 as a measure of immune response along the Alzheimer's disease continuum

1 reference

12 December 2020

STRING v11: protein–protein association networks with increased coverage, supporting functional discovery in genome-wide experimental datasets

1 reference

12 December 2020

Genome-wide meta-analysis identifies new loci and functional pathways influencing Alzheimer's disease risk

1 reference

12 December 2020

Early increase of CSF sTREM2 in Alzheimer's disease is associated with tau related-neurodegeneration but not with amyloid-β pathology

1 reference

12 December 2020

Transethnic meta-analysis of rare coding variants in PLCG2, ABI3, and TREM2 supports their general contribution to Alzheimer's disease

1 reference

12 December 2020

Alzheimer's disease phospholipase C-gamma-2 (PLCG2) protective variant is a functional hypermorph

1 reference

12 December 2020

Aggregated Tau activates NLRP3-ASC inflammasome exacerbating exogenously seeded and non-exogenously seeded Tau pathology in vivo

1 reference

12 December 2020

Implications of Microglia in Amyotrophic Lateral Sclerosis and Frontotemporal Dementia

1 reference

12 December 2020

Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing

1 reference

12 December 2020

Immune Signaling in Neurodegeneration

1 reference

12 December 2020

Single-cell transcriptomic analysis of Alzheimer's disease

1 reference

12 December 2020

GBA and APOE ε4 associate with sporadic dementia with Lewy bodies in European genome wide association study

1 reference

12 December 2020

WebGestalt 2019: gene set analysis toolkit with revamped UIs and APIs

1 reference

12 December 2020

A nonsynonymous mutation in PLCG2 reduces the risk of Alzheimer’s disease, dementia with Lewy bodies and frontotemporal dementia, and increases the likelihood of longevity

1 reference

12 December 2020

1 reference

12 December 2020

Association of MAPT H1 subhaplotypes with neuropathology of lewy body disease

1 reference

12 December 2020

Sustained microglial depletion with CSF1R inhibitor impairs parenchymal plaque development in an Alzheimer's disease model

1 reference

12 December 2020

Resistance to autosomal dominant Alzheimer’s disease in an APOE3 Christchurch homozygote: a case report

1 reference

12 December 2020

NLRP3 inflammasome activation drives tau pathology

1 reference

12 December 2020

Longitudinal transcriptomic analysis of altered pathways in a CHMP2Bintron5-based model of ALS-FTD

1 reference

12 December 2020