(Q50531818)

14 March 2018

title

Elevated TREM2 Gene Dosage Reprograms Microglia Responsivity and Ameliorates Pathological Phenotypes in Alzheimer's Disease Models. (English)

1 reference

14 March 2018

0 references

1 reference

C Y Daniel Lee

1

1 reference

14 March 2018

Anthony Daggett

2

1 reference

14 March 2018

Xiaofeng Gu

3

1 reference

14 March 2018

Lu-Lin Jiang

4

1 reference

14 March 2018

Peter Langfelder

5

1 reference

14 March 2018

Xiaoguang Li

6

1 reference

14 March 2018

Nan Wang

7

1 reference

14 March 2018

Yingjun Zhao

8

1 reference

14 March 2018

Chang Sin Park

9

1 reference

14 March 2018

Yonatan Cooper

10

1 reference

14 March 2018

Isabella Ferando

11

1 reference

14 March 2018

Istvan Mody

12

1 reference

14 March 2018

Giovanni Coppola

13

1 reference

14 March 2018

Huaxi Xu

14

1 reference

14 March 2018

X William Yang

15

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14 March 2018

language of work or name

English

0 references

publication date

1 March 2018

1 reference

14 March 2018

published in

Neuron

1 reference

14 March 2018

volume

97

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14 March 2018

page(s)

1032-1048.e5

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14 March 2018

issue

5

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14 March 2018

describes a project that uses

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC5927822/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

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25 August 2018

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25 August 2018

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25 August 2018

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25 August 2018

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25 August 2018

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25 August 2018

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Identification of a unique TGF-β-dependent molecular and functional signature in microglia

25 August 2018

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25 August 2018

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Integrated systems approach identifies genetic nodes and networks in late-onset Alzheimer's disease

25 August 2018

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25 August 2018

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Using exome sequencing to reveal mutations in TREM2 presenting as a frontotemporal dementia-like syndrome without bone involvement

25 August 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5927822

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25 August 2018

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TREM2 Variants in Alzheimer's Disease

25 August 2018

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Variant of TREM2 Associated with the Risk of Alzheimer's Disease

25 August 2018

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25 August 2018

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Fast R Functions for Robust Correlations and Hierarchical Clustering

25 August 2018

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The complement system: an unexpected role in synaptic pruning during development and disease

25 August 2018

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Network methods for describing sample relationships in genomic datasets: application to Huntington's disease

25 August 2018

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25 August 2018

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Apolipoprotein E promotes β-amyloid trafficking and degradation by modulating microglial cholesterol levels

25 August 2018

1 reference

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Early steps in steroidogenesis: intracellular cholesterol trafficking

25 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5927822

Galectin-3 is a new MerTK-specific eat-me signal

25 August 2018

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Changing face of microglia

25 August 2018

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Simple combinations of lineage-determining transcription factors prime cis-regulatory elements required for macrophage and B cell identities

25 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5927822

BEDTools: a flexible suite of utilities for comparing genomic features

25 August 2018

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Morphological alterations to neurons of the amygdala and impaired fear conditioning in a transgenic mouse model of Alzheimer's disease.

25 August 2018

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The role of Galectin-3/MAC-2 in the activation of the innate-immune function of phagocytosis in microglia in injury and disease

25 August 2018

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TREM and TREM-like receptors in inflammation and disease

25 August 2018

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WGCNA: an R package for weighted correlation network analysis

25 August 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5927822

Impairments in remote memory stabilization precede hippocampal synaptic and cognitive failures in 5XFAD Alzheimer mouse model

25 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5927822

Species-specific transcription in mice carrying human chromosome 21

25 August 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5927822

Geometric interpretation of gene coexpression network analysis

25 August 2018

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Modification of bacterial artificial chromosomes (BACs) and preparation of intact BAC DNA for generation of transgenic mice.

25 August 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5927822

A systems level analysis of transcriptional changes in Alzheimer's disease and normal aging

25 August 2018

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Autophagy, amyloidogenesis and Alzheimer disease

25 August 2018

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Eigengene networks for studying the relationships between co-expression modules

25 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5927822

Intraneuronal beta-amyloid aggregates, neurodegeneration, and neuron loss in transgenic mice with five familial Alzheimer's disease mutations: potential factors in amyloid plaque formation.

25 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5927822

Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles

25 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5927822

Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo

25 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5927822

Clearance of apoptotic neurons without inflammation by microglial triggering receptor expressed on myeloid cells-2.

25 August 2018

1 reference

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Mutant presenilins specifically elevate the levels of the 42 residue beta-amyloid peptide in vivo: evidence for augmentation of a 42-specific gamma secretase

25 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5927822

A gene expression atlas of the central nervous system based on bacterial artificial chromosomes

25 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5927822

Critical role of galectin-3 in phagocytosis by macrophages

25 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5927822

TREMs in the immune system and beyond

25 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5927822

Highly efficient modification of bacterial artificial chromosomes (BACs) using novel shuttle vectors containing the R6Kgamma origin of replication

25 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5927822

The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics

25 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5927822

Mutations in two genes encoding different subunits of a receptor signaling complex result in an identical disease phenotype

25 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5927822

Apolipoprotein E (ApoE) isoform-dependent lipid release from astrocytes prepared from human ApoE3 and ApoE4 knock-in mice

25 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5927822

BAC-mediated gene-dosage analysis reveals a role for Zipro1 (Ru49/Zfp38) in progenitor cell proliferation in cerebellum and skin.

25 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5927822

Homologous recombination based modification in Escherichia coli and germline transmission in transgenic mice of a bacterial artificial chromosome.

25 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5927822

Comparison of neurodegenerative pathology in transgenic mice overexpressing V717F beta-amyloid precursor protein and Alzheimer's disease

25 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5927822

Mutant mice and neuroscience: recommendations concerning genetic background. Banbury Conference on genetic background in mice

25 August 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/29518357

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1016/J.NEURON.2018.02.002

1 reference

14 March 2018

0 references

1 reference

14 March 2018