(Q90323926)

English

Autophagy blockade sensitizes human head and neck squamous cell carcinoma towards CYT997 through enhancing excessively high reactive oxygen species-induced apoptosis

scientific article published on 18 July 2018

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scholarly article

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30022281%20AND%20SRC:MED&resulttype=core&format=json

12 April 2020

Autophagy blockade sensitizes human head and neck squamous cell carcinoma towards CYT997 through enhancing excessively high reactive oxygen species-induced apoptosis (English)

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Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30022281%20AND%20SRC:MED&resulttype=core&format=json

12 April 2020

reactive oxygen species

1 reference

based on heuristic

inferred from title

1 reference

based on heuristic

inferred from title

head and neck squamous cell carcinoma

1 reference

based on heuristic

inferred from title

6

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30022281%20AND%20SRC:MED&resulttype=core&format=json

12 April 2020

author name string

Lixia Gao

1

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Europe PubMed Central

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12 April 2020

Xiangdong Zhao

2

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12 April 2020

Liwei Lang

3

1 reference

Europe PubMed Central

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12 April 2020

Chloe Shay

4

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Europe PubMed Central

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12 April 2020

W Andrew Yeudall

5

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Europe PubMed Central

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12 April 2020

publication date

18 July 2018

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Europe PubMed Central

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12 April 2020

Journal of Molecular Medicine

1 reference

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30022281%20AND%20SRC:MED&resulttype=core&format=json

12 April 2020

96

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Europe PubMed Central

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12 April 2020

9

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12 April 2020

929-938

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30022281%20AND%20SRC:MED&resulttype=core&format=json

12 April 2020

A direct linkage between the phosphoinositide 3-kinase-AKT signaling pathway and the mammalian target of rapamycin in mitogen-stimulated and transformed cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/30022281

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amino acid and insulin signaling via the mTOR/p70 S6 kinase pathway. A negative feedback mechanism leading to insulin resistance in skeletal muscle cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/30022281

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Resistance to paclitaxel is proportional to cellular total antioxidant capacity.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30022281

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Potential therapeutic applications of autophagy

1 reference

https://pubmed.ncbi.nlm.nih.gov/30022281

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Metformin inhibits mammalian target of rapamycin-dependent translation initiation in breast cancer cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/30022281

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phase I trial with the CD44v6-targeting immunoconjugate bivatuzumab mertansine in head and neck squamous cell carcinoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/30022281

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Targeting HER2-positive breast cancer with trastuzumab-DM1, an antibody-cytotoxic drug conjugate

1 reference

https://pubmed.ncbi.nlm.nih.gov/30022281

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nutrient-dependent mTORC1 association with the ULK1-Atg13-FIP200 complex required for autophagy

1 reference

https://pubmed.ncbi.nlm.nih.gov/30022281

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Discovery of CYT997: a structurally novel orally active microtubule targeting agent

1 reference

https://pubmed.ncbi.nlm.nih.gov/30022281

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

CYT997: a novel orally active tubulin polymerization inhibitor with potent cytotoxic and vascular disrupting activity in vitro and in vivo.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30022281

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dual role of 3-methyladenine in modulation of autophagy via different temporal patterns of inhibition on class I and III phosphoinositide 3-kinase

1 reference

https://pubmed.ncbi.nlm.nih.gov/30022281

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Methods in mammalian autophagy research

1 reference

https://pubmed.ncbi.nlm.nih.gov/30022281

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Targeting cancer cell metabolism: the combination of metformin and 2-deoxyglucose induces p53-dependent apoptosis in prostate cancer cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/30022281

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Understanding the "lethal" drivers of tumor-stroma co-evolution: emerging role(s) for hypoxia, oxidative stress and autophagy/mitophagy in the tumor micro-environment

1 reference

https://pubmed.ncbi.nlm.nih.gov/30022281

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Microtubule-binding agents: a dynamic field of cancer therapeutics

1 reference

https://pubmed.ncbi.nlm.nih.gov/30022281

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The molecular biology of head and neck cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/30022281

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mitosis is not a key target of microtubule agents in patient tumors.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30022281

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The mutational landscape of head and neck squamous cell carcinoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/30022281

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Targeting autophagy potentiates chemotherapy-induced apoptosis and proliferation inhibition in hepatocarcinoma cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/30022281

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ceramide targets autophagosomes to mitochondria and induces lethal mitophagy

1 reference

https://pubmed.ncbi.nlm.nih.gov/30022281

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Autophagy as a stress-response and quality-control mechanism: implications for cell injury and human disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/30022281

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interconnections between apoptotic, autophagic and necrotic pathways: implications for cancer therapy development

1 reference

https://pubmed.ncbi.nlm.nih.gov/30022281

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Autophagy and chemotherapy resistance: a promising therapeutic target for cancer treatment

1 reference

https://pubmed.ncbi.nlm.nih.gov/30022281

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The microtubule depolymerizing agent CYT997 effectively kills acute myeloid leukemia cells via activation of caspases and inhibition of PI3K/Akt/mTOR pathway proteins

1 reference

https://pubmed.ncbi.nlm.nih.gov/30022281

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The histone H3 methyltransferase G9A epigenetically activates the serine-glycine synthesis pathway to sustain cancer cell survival and proliferation

1 reference

https://pubmed.ncbi.nlm.nih.gov/30022281

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Targeting microtubules by natural agents for cancer therapy

1 reference

https://pubmed.ncbi.nlm.nih.gov/30022281

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

How Taxol/paclitaxel kills cancer cells.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30022281

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tubulin colchicine binding site inhibitors as vascular disrupting agents in clinical developments

1 reference

https://pubmed.ncbi.nlm.nih.gov/30022281

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacologic agents targeting autophagy

1 reference

https://pubmed.ncbi.nlm.nih.gov/30022281

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Calcium homeostasis and ER stress in control of autophagy in cancer cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/30022281

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mitochondrial ATAD3A combines with GRP78 to regulate the WASF3 metastasis-promoting protein

1 reference

https://pubmed.ncbi.nlm.nih.gov/30022281

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cancer statistics, 2016

1 reference

https://pubmed.ncbi.nlm.nih.gov/30022281

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Looking at the metabolic consequences of the colchicine-based in vivo autophagic flux assay

1 reference

https://pubmed.ncbi.nlm.nih.gov/30022281

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Exploiting plug-and-play electrochemistry for drug discovery

1 reference

https://pubmed.ncbi.nlm.nih.gov/30022281

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

ARF1 promotes prostate tumorigenesis via targeting oncogenic MAPK signaling.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30022281

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A Novel Resveratrol Based Tubulin Inhibitor Induces Mitotic Arrest and Activates Apoptosis in Cancer Cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/30022281

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

FGF19/FGFR4 signaling contributes to the resistance of hepatocellular carcinoma to sorafenib.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30022281

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Targeting autophagy as a strategy for drug discovery and therapeutic modulation

1 reference

https://pubmed.ncbi.nlm.nih.gov/30022281

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Deficiency of the hepatokine selenoprotein P increases responsiveness to exercise in mice through upregulation of reactive oxygen species and AMP-activated protein kinase in muscle.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30022281

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Augmentation of the anticancer activity of CYT997 in human prostate cancer by inhibiting Src activity.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30022281

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nocturnal activation of melatonin receptor type 1 signaling modulates diurnal insulin sensitivity via regulation of PI3K activity.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30022281

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1007/S00109-018-1670-5

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30022281%20AND%20SRC:MED&resulttype=core&format=json

12 April 2020

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30022281%20AND%20SRC:MED&resulttype=core&format=json

12 April 2020

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