(Q90401888)

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High-Parameter Mass Cytometry Evaluation of Relapsed/Refractory Multiple Myeloma Patients Treated with Daratumumab Demonstrates Immune Modulation as a Novel Mechanism of Action

scientific article published on 11 December 2018

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13 April 2020

High-Parameter Mass Cytometry Evaluation of Relapsed/Refractory Multiple Myeloma Patients Treated with Daratumumab Demonstrates Immune Modulation as a Novel Mechanism of Action (English)

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13 April 2020

multiple myeloma

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inferred from title

7

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13 April 2020

Niels W C J van de Donk

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Niels W C J van de Donk

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13 April 2020

16

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Tuna Mutis

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13 April 2020

Henk M. Lokhorst

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Henk M Lokhorst

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13 April 2020

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Homer C Adams

1

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13 April 2020

Frederik Stevenaert

2

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13 April 2020

Jakub Krejcik

3

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13 April 2020

Koen Van der Borght

4

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13 April 2020

Tina Smets

5

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13 April 2020

Jaime Bald

6

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13 April 2020

Hugo Ceulemans

8

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13 April 2020

Christopher Chiu

9

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13 April 2020

Greet Vanhoof

10

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13 April 2020

Saad Z Usmani

11

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13 April 2020

Torben Plesner

12

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13 April 2020

Sagar Lonial

13

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13 April 2020

Inger Nijhof

14

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13 April 2020

Amy Kate Sasser

18

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13 April 2020

Tineke Casneuf

19

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13 April 2020

publication date

11 December 2018

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13 April 2020

Cytometry Part A

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13 April 2020

95

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13 April 2020

3

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13 April 2020

279-289

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13 April 2020

Daratumumab, a novel therapeutic human CD38 monoclonal antibody, induces killing of multiple myeloma and other hematological tumors.

1 reference

https://api.crossref.org/works/10.1002%2FCYTO.A.23693

7 January 2021

based on heuristic

inferred from DOI database lookup

Flow cytometric detection of aneuploid CD38(++) plasmacells and CD19(+) B-lymphocytes in bone marrow, peripheral blood and PBSC harvest in multiple myeloma patients.

1 reference

https://api.crossref.org/works/10.1002%2FCYTO.A.23693

7 January 2021

based on heuristic

inferred from DOI database lookup

Human CD38: a (r)evolutionary story of enzymes and receptors

1 reference

https://api.crossref.org/works/10.1002%2FCYTO.A.23693

7 January 2021

based on heuristic

inferred from DOI database lookup

Targeting CD38 with Daratumumab Monotherapy in Multiple Myeloma

1 reference

https://api.crossref.org/works/10.1002%2FCYTO.A.23693

7 January 2021

based on heuristic

inferred from DOI database lookup

Daratumumab monotherapy in patients with treatment-refractory multiple myeloma (SIRIUS): an open-label, randomised, phase 2 trial

1 reference

https://api.crossref.org/works/10.1002%2FCYTO.A.23693

7 January 2021

based on heuristic

inferred from DOI database lookup

Phase 1/2 study of daratumumab, lenalidomide, and dexamethasone for relapsed multiple myeloma.

1 reference

https://api.crossref.org/works/10.1002%2FCYTO.A.23693

7 January 2021

based on heuristic

inferred from DOI database lookup

Daratumumab, Bortezomib, and Dexamethasone for Multiple Myeloma

1 reference

https://api.crossref.org/works/10.1002%2FCYTO.A.23693

7 January 2021

based on heuristic

inferred from DOI database lookup

Daratumumab, Lenalidomide, and Dexamethasone for Multiple Myeloma

1 reference

https://api.crossref.org/works/10.1002%2FCYTO.A.23693

7 January 2021

based on heuristic

inferred from DOI database lookup

Daratumumab plus pomalidomide and dexamethasone in relapsed and/or refractory multiple myeloma

1 reference

https://api.crossref.org/works/10.1002%2FCYTO.A.23693

7 January 2021

based on heuristic

inferred from DOI database lookup

Antibody-mediated phagocytosis contributes to the anti-tumor activity of the therapeutic antibody daratumumab in lymphoma and multiple myeloma

1 reference

https://api.crossref.org/works/10.1002%2FCYTO.A.23693

7 January 2021

based on heuristic

inferred from DOI database lookup

The Therapeutic CD38 Monoclonal Antibody Daratumumab Induces Programmed Cell Death via Fcγ Receptor-Mediated Cross-Linking

1 reference

https://api.crossref.org/works/10.1002%2FCYTO.A.23693

7 January 2021

based on heuristic

inferred from DOI database lookup

Daratumumab depletes CD38+ immune regulatory cells, promotes T-cell expansion, and skews T-cell repertoire in multiple myeloma

1 reference

https://api.crossref.org/works/10.1002%2FCYTO.A.23693

7 January 2021

based on heuristic

inferred from DOI database lookup

Mass cytometry: technique for real time single cell multitarget immunoassay based on inductively coupled plasma time-of-flight mass spectrometry

1 reference

https://api.crossref.org/works/10.1002%2FCYTO.A.23693

7 January 2021

based on heuristic

inferred from DOI database lookup

Single-cell mass cytometry of differential immune and drug responses across a human hematopoietic continuum

1 reference

https://api.crossref.org/works/10.1002%2FCYTO.A.23693

7 January 2021

based on heuristic

inferred from DOI database lookup

Inferring phenotypic properties from single-cell characteristics

1 reference

https://api.crossref.org/works/10.1002%2FCYTO.A.23693

7 January 2021

based on heuristic

inferred from DOI database lookup

Characterizing cell subsets using marker enrichment modeling

1 reference

https://api.crossref.org/works/10.1002%2FCYTO.A.23693

7 January 2021

based on heuristic

inferred from DOI database lookup

Extracting a cellular hierarchy from high-dimensional cytometry data with SPADE

1 reference

https://api.crossref.org/works/10.1002%2FCYTO.A.23693

7 January 2021

based on heuristic

inferred from DOI database lookup

Exploring Glucocorticoid Receptor Agonists Mechanism of Action Through Mass Cytometry and Radial Visualizations

1 reference

https://api.crossref.org/works/10.1002%2FCYTO.A.23693

7 January 2021

based on heuristic

inferred from DOI database lookup

CD38 expression and complement inhibitors affect response and resistance to daratumumab therapy in myeloma

1 reference

https://api.crossref.org/works/10.1002%2FCYTO.A.23693

7 January 2021

based on heuristic

inferred from DOI database lookup

Effects of daratumumab on natural killer cells and impact on clinical outcomes in relapsed or refractory multiple myeloma

1 reference

https://api.crossref.org/works/10.1002%2FCYTO.A.23693

7 January 2021

based on heuristic

inferred from DOI database lookup

Lymphocyte-mediated cytotoxicity.

1 reference

https://api.crossref.org/works/10.1002%2FCYTO.A.23693

7 January 2021

based on heuristic

inferred from DOI database lookup

Dasatinib Changes Immune Cell Profiles Concomitant with Reduced Tumor Growth in Several Murine Solid Tumor Models

1 reference

https://api.crossref.org/works/10.1002%2FCYTO.A.23693

7 January 2021

based on heuristic

inferred from DOI database lookup

PARP Inhibitor Upregulates PD-L1 Expression and Enhances Cancer-Associated Immunosuppression.

1 reference

https://api.crossref.org/works/10.1002%2FCYTO.A.23693

7 January 2021

based on heuristic

inferred from DOI database lookup

Combined targeting of BCL-2 and BCR-ABL tyrosine kinase eradicates chronic myeloid leukemia stem cells

1 reference

https://api.crossref.org/works/10.1002%2FCYTO.A.23693

7 January 2021

based on heuristic

inferred from DOI database lookup

Epidemiology, Mechanisms, and Diagnosis of Drug-Induced Anaphylaxis

1 reference

https://api.crossref.org/works/10.1002%2FCYTO.A.23693

7 January 2021

based on heuristic

inferred from DOI database lookup

CD27 defines phenotypically and functionally different human NK cell subsets

1 reference

https://api.crossref.org/works/10.1002%2FCYTO.A.23693

7 January 2021

based on heuristic

inferred from DOI database lookup

CD27 dissects mature NK cells into two subsets with distinct responsiveness and migratory capacity

1 reference

https://api.crossref.org/works/10.1002%2FCYTO.A.23693

7 January 2021

based on heuristic

inferred from DOI database lookup

Maturation of mouse NK cells is a 4-stage developmental program.

1 reference

https://api.crossref.org/works/10.1002%2FCYTO.A.23693

7 January 2021

based on heuristic

inferred from DOI database lookup

Subsets of human natural killer cells and their regulatory effects

1 reference

https://api.crossref.org/works/10.1002%2FCYTO.A.23693

7 January 2021

based on heuristic

inferred from DOI database lookup

CD45 Isoform Profile Identifies Natural Killer (NK) Subsets with Differential Activity.

1 reference

https://api.crossref.org/works/10.1002%2FCYTO.A.23693

7 January 2021

based on heuristic

inferred from DOI database lookup

Identification of Anti-tumor Cells Carrying Natural Killer (NK) Cell Antigens in Patients With Hematological Cancers

1 reference

https://api.crossref.org/works/10.1002%2FCYTO.A.23693

7 January 2021

based on heuristic

inferred from DOI database lookup

Fratricide of NK Cells in Daratumumab Therapy for Multiple Myeloma Overcome by Ex Vivo Expanded Autologous NK Cells.

1 reference

https://api.crossref.org/works/10.1002%2FCYTO.A.23693

7 January 2021

based on heuristic

inferred from DOI database lookup

Targeting CD38 Suppresses Induction and Function of T Regulatory Cells to Mitigate Immunosuppression in Multiple Myeloma

1 reference

https://api.crossref.org/works/10.1002%2FCYTO.A.23693

7 January 2021

based on heuristic

inferred from DOI database lookup

T cells in multiple myeloma display features of exhaustion and senescence at the tumor site.

1 reference

https://api.crossref.org/works/10.1002%2FCYTO.A.23693

7 January 2021

based on heuristic

inferred from DOI database lookup

Multiple myeloma causes clonal T-cell immunosenescence: identification of potential novel targets for promoting tumour immunity and implications for checkpoint blockade.

1 reference

https://api.crossref.org/works/10.1002%2FCYTO.A.23693

7 January 2021

based on heuristic

inferred from DOI database lookup

CD38-NAD+Axis Regulates Immunotherapeutic Anti-Tumor T Cell Response.

1 reference

https://api.crossref.org/works/10.1002%2FCYTO.A.23693

7 January 2021

based on heuristic

inferred from DOI database lookup

Flow cytometric immunophenotypic analysis of 306 cases of multiple myeloma

1 reference

https://pubmed.ncbi.nlm.nih.gov/30536810

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evaluation of a 12-color flow cytometry panel to study lymphocyte, monocyte, and dendritic cell subsets in humans

1 reference

https://pubmed.ncbi.nlm.nih.gov/30536810

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1002/CYTO.A.23693

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30536810%20AND%20SRC:MED&resulttype=core&format=json

13 April 2020

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30536810%20AND%20SRC:MED&resulttype=core&format=json

13 April 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30536810%20AND%20SRC:MED&resulttype=core&format=json

13 April 2020

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