(Q90568402)

English

Targeting glutaminase 1 attenuates stemness properties in hepatocellular carcinoma by increasing reactive oxygen species and suppressing Wnt/beta-catenin pathway

scientific article published on 13 December 2018

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scholarly article

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14 April 2020

Targeting glutaminase 1 attenuates stemness properties in hepatocellular carcinoma by increasing reactive oxygen species and suppressing Wnt/beta-catenin pathway (English)

1 reference

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14 April 2020

reactive oxygen species

1 reference

based on heuristic

inferred from title

hepatocellular carcinoma

1 reference

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inferred from title

author name string

Binghua Li

1

1 reference

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14 April 2020

Yajuan Cao

2

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14 April 2020

Gang Meng

3

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14 April 2020

Liyuan Qian

4

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14 April 2020

Tiancheng Xu

5

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14 April 2020

Chen Yan

6

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14 April 2020

Ouyang Luo

7

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14 April 2020

Shaohe Wang

8

1 reference

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14 April 2020

Jiwu Wei

9

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14 April 2020

Yitao Ding

10

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14 April 2020

Decai Yu

11

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14 April 2020

publication date

13 December 2018

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14 April 2020

1 reference

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14 April 2020

39

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14 April 2020

239-254

1 reference

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14 April 2020

Cloning and analysis of unique human glutaminase isoforms generated by tissue-specific alternative splicing

1 reference

https://pubmed.ncbi.nlm.nih.gov/30555042

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of two human glutaminase loci and tissue-specific expression of the two related genes.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30555042

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

New targets of beta-catenin signaling in the liver are involved in the glutamine metabolism

1 reference

https://pubmed.ncbi.nlm.nih.gov/30555042

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hydrogen peroxide negatively modulates Wnt signaling through downregulation of beta-catenin

1 reference

https://pubmed.ncbi.nlm.nih.gov/30555042

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Antisense glutaminase inhibition decreases glutathione antioxidant capacity and increases apoptosis in Ehrlich ascitic tumour cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/30555042

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Liver-specific loss of beta-catenin blocks glutamine synthesis pathway activity and cytochrome p450 expression in mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/30555042

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Wnt/beta-catenin signaling in cancer stemness and malignant behavior

1 reference

https://pubmed.ncbi.nlm.nih.gov/30555042

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification and characterization of tumorigenic liver cancer stem/progenitor cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/30555042

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Enhanced self-renewal capability in hepatic stem/progenitor cells drives cancer initiation.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30555042

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activation of hepatic stem cell marker EpCAM by Wnt-beta-catenin signaling in hepatocellular carcinoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/30555042

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Module map of stem cell genes guides creation of epithelial cancer stem cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/30555042

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Wnt/beta-catenin signaling contributes to activation of normal and tumorigenic liver progenitor cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/30555042

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

EpCAM-positive hepatocellular carcinoma cells are tumor-initiating cells with stem/progenitor cell features

1 reference

https://pubmed.ncbi.nlm.nih.gov/30555042

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

c-Myc suppression of miR-23a/b enhances mitochondrial glutaminase expression and glutamine metabolism

1 reference

https://pubmed.ncbi.nlm.nih.gov/30555042

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cancer stem cells in hepatocellular carcinoma: Recent progress and perspective

1 reference

https://pubmed.ncbi.nlm.nih.gov/30555042

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cancer stem/progenitor cells are highly enriched in CD133+CD44+ population in hepatocellular carcinoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/30555042

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Targeting Wnt signaling: can we safely eradicate cancer stem cells?

1 reference

https://pubmed.ncbi.nlm.nih.gov/30555042

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Targeting mitochondrial glutaminase activity inhibits oncogenic transformation

1 reference

https://pubmed.ncbi.nlm.nih.gov/30555042

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of reactive oxygen species in stem cells and cancer stem cells.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30555042

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Small molecule-based disruption of the Axin/β-catenin protein complex regulates mesenchymal stem cell differentiation

1 reference

https://pubmed.ncbi.nlm.nih.gov/30555042

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mitochondrial localization and structure-based phosphate activation mechanism of Glutaminase C with implications for cancer metabolism

1 reference

https://pubmed.ncbi.nlm.nih.gov/30555042

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reactive oxygen species in cancer stem cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/30555042

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Structural basis for the allosteric inhibitory mechanism of human kidney-type glutaminase (KGA) and its regulation by Raf-Mek-Erk signaling in cancer cell metabolism

1 reference

https://pubmed.ncbi.nlm.nih.gov/30555042

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Wnt/β-catenin signaling and disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/30555042

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Analysis of glutamine dependency in non-small cell lung cancer: GLS1 splice variant GAC is essential for cancer cell growth

1 reference

https://pubmed.ncbi.nlm.nih.gov/30555042

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cancer stem cells in the development of liver cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/30555042

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Multifunctional antitumor molecule 5'-triphosphate siRNA combining glutaminase silencing and RIG-I activation

1 reference

https://pubmed.ncbi.nlm.nih.gov/30555042

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glutamine and cancer: cell biology, physiology, and clinical opportunities

1 reference

https://pubmed.ncbi.nlm.nih.gov/30555042

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Both GLS silencing and GLS2 overexpression synergize with oxidative stress against proliferation of glioma cells.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30555042

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Stem cells and the impact of ROS signaling

1 reference

https://pubmed.ncbi.nlm.nih.gov/30555042

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mesenchymal phenotype predisposes lung cancer cells to impaired proliferation and redox stress in response to glutaminase inhibition

1 reference

https://pubmed.ncbi.nlm.nih.gov/30555042

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Unconventional PINK1 localization to the outer membrane of depolarized mitochondria drives Parkin recruitment

1 reference

https://pubmed.ncbi.nlm.nih.gov/30555042

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Kidney-type glutaminase (GLS1) is a biomarker for pathologic diagnosis and prognosis of hepatocellular carcinoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/30555042

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Targeted inhibition of tumor-specific glutaminase diminishes cell-autonomous tumorigenesis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30555042

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Targeting glutaminolysis has antileukemic activity in acute myeloid leukemia and synergizes with BCL-2 inhibition

1 reference

https://pubmed.ncbi.nlm.nih.gov/30555042

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

ZIC2-dependent OCT4 activation drives self-renewal of human liver cancer stem cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/30555042

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glutaminases in slowly proliferating gastroenteropancreatic neuroendocrine neoplasms/tumors (GEP-NETs): Selective overexpression of mRNA coding for the KGA isoform

1 reference

https://pubmed.ncbi.nlm.nih.gov/30555042

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

NANOG Metabolically Reprograms Tumor-Initiating Stem-like Cells through Tumorigenic Changes in Oxidative Phosphorylation and Fatty Acid Metabolism.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30555042

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glutaminase 2 is a novel negative regulator of small GTPase Rac1 and mediates p53 function in suppressing metastasis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30555042

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dlx-2 and glutaminase upregulate epithelial-mesenchymal transition and glycolytic switch

1 reference

https://pubmed.ncbi.nlm.nih.gov/30555042

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Allele-Specific Reprogramming of Cancer Metabolism by the Long Non-coding RNA CCAT2.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30555042

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Energy metabolism in the acquisition and maintenance of stemness

1 reference

https://pubmed.ncbi.nlm.nih.gov/30555042

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

CFIm25 regulates glutaminase alternative terminal exon definition to modulate miR-23 function

1 reference

https://pubmed.ncbi.nlm.nih.gov/30555042

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hallmarks of cancer stem cell metabolism.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30555042

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cancer stem cell metabolism

1 reference

https://pubmed.ncbi.nlm.nih.gov/30555042

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Combination therapy with BPTES nanoparticles and metformin targets the metabolic heterogeneity of pancreatic cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/30555042

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glutaminase inhibitor compound 968 inhibits cell proliferation and sensitizes paclitaxel in ovarian cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/30555042

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A tale of two glutaminases: homologous enzymes with distinct roles in tumorigenesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/30555042

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The evolving concept of liver cancer stem cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/30555042

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Head and Neck Squamous Cell Carcinoma Metabolism Draws on Glutaminolysis, and Stemness Is Specifically Regulated by Glutaminolysis via Aldehyde Dehydrogenase

1 reference

https://pubmed.ncbi.nlm.nih.gov/30555042

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of stem-like cancer cells by glutamine through β-catenin pathway mediated by redox signaling

1 reference

https://pubmed.ncbi.nlm.nih.gov/30555042

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The origin and evolution of human glutaminases and their atypical C-terminal ankyrin repeats.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30555042

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hepatocellular carcinoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/30555042

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phosphorylation of glutaminase by PKCε is essential for its enzymatic activity and critically contributes to tumorigenesis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30555042

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Machine Learning Identifies Stemness Features Associated with Oncogenic Dedifferentiation.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30555042

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Liver-enriched Genes are Associated with the Prognosis of Patients with Hepatocellular Carcinoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/30555042

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1016/J.EBIOM.2018.11.063

1 reference

Europe PubMed Central

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14 April 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30555042%20AND%20SRC:MED&resulttype=core&format=json

14 April 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30555042%20AND%20SRC:MED&resulttype=core&format=json

14 April 2020

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