(Q34691457)

4 August 2017

title

Mesenchymal phenotype predisposes lung cancer cells to impaired proliferation and redox stress in response to glutaminase inhibition (English)

1 reference

4 August 2017

1 reference

Danielle B Ulanet

1

1 reference

4 August 2017

Kiley Couto

2

1 reference

4 August 2017

Abhishek Jha

3

1 reference

4 August 2017

Sung Choe

4

1 reference

4 August 2017

Amanda Wang

5

1 reference

4 August 2017

Hin-Koon Woo

6

1 reference

4 August 2017

Mya Steadman

7

1 reference

4 August 2017

Byron DeLaBarre

8

1 reference

4 August 2017

Stefan Gross

9

1 reference

4 August 2017

Edward Driggers

10

1 reference

4 August 2017

Marion Dorsch

11

1 reference

4 August 2017

Jonathan B Hurov

12

1 reference

4 August 2017

language of work or name

English

0 references

publication date

12 December 2014

1 reference

4 August 2017

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4 August 2017

volume

9

1 reference

4 August 2017

issue

12

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4 August 2017

page(s)

e115144

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Creative Commons Attribution 4.0 International

4 August 2017

copyright license

start time

12 December 2014

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

cites work

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7 July 2018

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Glutamine sensitivity analysis identifies the xCT antiporter as a common triple-negative breast tumor therapeutic target

7 July 2018

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In vivo HIF-mediated reductive carboxylation is regulated by citrate levels and sensitizes VHL-deficient cells to glutamine deprivation

7 July 2018

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7 July 2018

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7 July 2018

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Susceptibility of human head and neck cancer cells to combined inhibition of glutathione and thioredoxin metabolism

7 July 2018

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7 July 2018

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7 July 2018

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Analysis of glutamine dependency in non-small cell lung cancer: GLS1 splice variant GAC is essential for cancer cell growth

7 July 2018

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7 July 2018

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Pyruvate fuels mitochondrial respiration and proliferation of breast cancer cells: effect of monocarboxylate transporter inhibition.

7 July 2018

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IDH mutation impairs histone demethylation and results in a block to cell differentiation

7 July 2018

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7 July 2018

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Free radical generation induces epithelial-to-mesenchymal transition in lung epithelium via a TGF-β1-dependent mechanism

7 July 2018

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Glucose-independent glutamine metabolism via TCA cycling for proliferation and survival in B cells

7 July 2018

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Have we enough glutamine and how does it work? A clinician's view

7 July 2018

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Epithelial-mesenchymal transition and breast cancer: role, molecular mechanisms and clinical impact.

7 July 2018

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An in vitro investigation of metabolically sensitive biomarkers in breast cancer progression

7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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Inhibition of lung cancer growth: ATP citrate lyase knockdown and statin treatment leads to dual blockade of mitogen-activated protein kinase (MAPK) and phosphatidylinositol-3-kinase (PI3K)/AKT pathways

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4264947

Pyruvate carboxylase is required for glutamine-independent growth of tumor cells

7 July 2018

1 reference

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A systems view of epithelial-mesenchymal transition signaling states

7 July 2018

1 reference

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The hexosamine biosynthetic pathway couples growth factor-induced glutamine uptake to glucose metabolism

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4264947

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7 July 2018

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Inhibition of glutaminase preferentially slows growth of glioma cells with mutant IDH1.

7 July 2018

1 reference

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Targeting mitochondrial glutaminase activity inhibits oncogenic transformation

7 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4264947

TGF-beta IL-6 axis mediates selective and adaptive mechanisms of resistance to molecular targeted therapy in lung cancer

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4264947

EMT, cancer stem cells and drug resistance: an emerging axis of evil in the war on cancer

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4264947

Phosphate-activated glutaminase (GLS2), a p53-inducible regulator of glutamine metabolism and reactive oxygen species

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4264947

Q's next: the diverse functions of glutamine in metabolism, cell biology and cancer

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4264947

c-Myc suppression of miR-23a/b enhances mitochondrial glutaminase expression and glutamine metabolism

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4264947

Myc regulates a transcriptional program that stimulates mitochondrial glutaminolysis and leads to glutamine addiction

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4264947

The upstream components of the Wnt signalling pathway in the dynamic EMT and MET associated with colorectal cancer progression

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4264947

Bypassing cellular EGF receptor dependence through epithelial-to-mesenchymal-like transitions

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4264947

Metabolic reconfiguration is a regulated response to oxidative stress.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4264947

Beyond aerobic glycolysis: transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4264947

Collagen I promotes epithelial-to-mesenchymal transition in lung cancer cells via transforming growth factor-beta signaling

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4264947

TGF-beta signaling and its effect on glutaminase expression in LLC-PK1-FBPase+ cells

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4264947

Novel mechanism of inhibition of rat kidney-type glutaminase by bis-2-(5-phenylacetamido-1,2,4-thiadiazol-2-yl)ethyl sulfide (BPTES)

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4264947

NAD(P)H oxidase 4 mediates transforming growth factor-beta1-induced differentiation of cardiac fibroblasts into myofibroblasts

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4264947

Inhibition of glutaminase expression by antisense mRNA decreases growth and tumourigenicity of tumour cells

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4264947

Cellular recovery of glyceraldehyde-3-phosphate dehydrogenase activity and thiol status after exposure to hydroperoxides

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4264947

Identification of two human glutaminase loci and tissue-specific expression of the two related genes.

7 July 2018

1 reference

Crossref

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0115144

Regulation of the activity of glyceraldehyde 3-phosphate dehydrogenase by glutathione and H2O2

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25502225

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

The growth response of mammalian cells in tissue culture to L-glutamine and L-glutamic acid

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25502225

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Glutaminase of the human malignant cell, strain HeLa

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25502225

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1371/JOURNAL.PONE.0115144

1 reference

4 August 2017

0 references

1 reference

4 August 2017

1 reference