(Q38007261)

1 July 2019

title

Cancer stem cells and epithelial-mesenchymal transition: concepts and molecular links (English)

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1 July 2019

main subject

neoplastic stem cells

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2

Robert A Weinberg

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author name string

Christina Scheel

series ordinal

1

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1 July 2019

language of work or name

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23 April 2012

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1 July 2019

Seminars in Cancer Biology

published in

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1 July 2019

volume

22

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1 July 2019

issue

5-6

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1 July 2019

page(s)

396-403

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1 July 2019

Downregulation of miRNA-200c links breast cancer stem cells with normal stem cells

cites work

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12 December 2020

The morphological and molecular features of the epithelial-to-mesenchymal transition

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12 December 2020

The ins and outs of the epithelial to mesenchymal transition in health and disease

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12 December 2020

Opinion: migrating cancer stem cells - an integrated concept of malignant tumour progression

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12 December 2020

Tumor patterning: analogies of neoplastic morphogenesis with embryogenesis.

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12 December 2020

Illegitimate WNT pathway activation by beta-catenin mutation or autocrine stimulation in T-cell malignancies.

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12 December 2020

Molecular signaling of the epithelial to mesenchymal transition in generating and maintaining cancer stem cells

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12 December 2020

Understanding the cancer stem cell.

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12 December 2020

TGF-beta-FOXO signalling maintains leukaemia-initiating cells in chronic myeloid leukaemia

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12 December 2020

Biological and molecular heterogeneity of breast cancers correlates with their cancer stem cell content

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12 December 2020

Epithelial to mesenchymal transition derived from repeated exposure to gefitinib determines the sensitivity to EGFR inhibitors in A549, a non-small cell lung cancer cell line

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12 December 2020

EMT, cancer stem cells and drug resistance: an emerging axis of evil in the war on cancer

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12 December 2020

Beta-catenin signaling, liver regeneration and hepatocellular cancer: sorting the good from the bad.

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12 December 2020

Regulation of tight junctions during the epithelium-mesenchyme transition: direct repression of the gene expression of claudins/occludin by Snail

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12 December 2020

Retinoic acid maintains self-renewal of murine embryonic stem cells via a feedback mechanism

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12 December 2020

A reciprocal repression between ZEB1 and members of the miR-200 family promotes EMT and invasion in cancer cells

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12 December 2020

A double-negative feedback loop between ZEB1-SIP1 and the microRNA-200 family regulates epithelial-mesenchymal transition

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12 December 2020

Normal stem cells and cancer stem cells: similar and different

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12 December 2020

Cancer stem cells in breast: current opinion and future challenges.

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12 December 2020

Epithelial-mesenchymal transition: at the crossroads of development and tumor metastasis

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12 December 2020

A transient, EMT-linked loss of basement membranes indicates metastasis and poor survival in colorectal cancer

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12 December 2020

Epithelial-mesenchymal transitions in development and disease

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12 December 2020

Critical determinants of metastasis

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12 December 2020

A cell initiating human acute myeloid leukaemia after transplantation into SCID mice

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12 December 2020

Gastrointestinal stem cells in development and cancer

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12 December 2020

Residual breast cancers after conventional therapy display mesenchymal as well as tumor-initiating features

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12 December 2020

Oncogenic cooperation between H-Twist and N-Myc overrides failsafe programs in cancer cells.

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12 December 2020

Distinct populations of cancer stem cells determine tumor growth and metastatic activity in human pancreatic cancer

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12 December 2020

Mesenchymal-to-epithelial transition facilitates bladder cancer metastasis: role of fibroblast growth factor receptor-2.

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12 December 2020

The transcription factors Slug and Snail act as repressors of Claudin-1 expression in epithelial cells.

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12 December 2020

Genetic interaction of PGE2 and Wnt signaling regulates developmental specification of stem cells and regeneration

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12 December 2020

A human colon cancer cell capable of initiating tumour growth in immunodeficient mice

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12 December 2020

The miR-200 family inhibits epithelial-mesenchymal transition and cancer cell migration by direct targeting of E-cadherin transcriptional repressors ZEB1 and ZEB2

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12 December 2020

Up-regulation of Twist induces angiogenesis and correlates with metastasis in hepatocellular carcinoma

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12 December 2020

Targeting Wnt signaling: can we safely eradicate cancer stem cells?

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12 December 2020

The miR-200 family determines the epithelial phenotype of cancer cells by targeting the E-cadherin repressors ZEB1 and ZEB2

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12 December 2020

Nuclear overexpression of the oncoprotein beta-catenin in colorectal cancer is localized predominantly at the invasion front.

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12 December 2020

Loss of beta-catenin impairs the renewal of normal and CML stem cells in vivo

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12 December 2020

Acquisition of epithelial-mesenchymal transition phenotype of gemcitabine-resistant pancreatic cancer cells is linked with activation of the notch signaling pathway

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12 December 2020

Identification of selective inhibitors of cancer stem cells by high-throughput screening

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12 December 2020

The transcription factor snail controls epithelial-mesenchymal transitions by repressing E-cadherin expression

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12 December 2020

The EMT-activator ZEB1 promotes tumorigenicity by repressing stemness-inhibiting microRNAs

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12 December 2020

Interplay of cadherin-mediated cell adhesion and canonical Wnt signaling

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12 December 2020

Efficient tumour formation by single human melanoma cells

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12 December 2020

Mechanisms of motility in metastasizing cells

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12 December 2020

Cancer stem cells: problems for therapy?

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12 December 2020

The enigmatic primitive streak: prevailing notions and challenges concerning the body axis of mammals

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12 December 2020

Cancer metastasis as a therapeutic target

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12 December 2020

The epithelial-mesenchymal transition generates cells with properties of stem cells

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12 December 2020

A Wnt survival guide: from flies to human disease.

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12 December 2020

Normal and neoplastic nonstem cells can spontaneously convert to a stem-like state

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12 December 2020

The miR-200 family and miR-205 regulate epithelial to mesenchymal transition by targeting ZEB1 and SIP1

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12 December 2020

Transformations between epithelium and mesenchyme: normal, pathological, and experimentally induced

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12 December 2020

E-cadherin, beta-catenin, and ZEB1 in malignant progression of cancer

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12 December 2020

Wnt activity defines colon cancer stem cells and is regulated by the microenvironment

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12 December 2020

Slug antagonizes p53-mediated apoptosis of hematopoietic progenitors by repressing puma

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12 December 2020

Multiple myeloma: a paradigm for translation of the cancer stem cell hypothesis

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12 December 2020

Loss of miR-200 Inhibition of Suz12 Leads to Polycomb-Mediated Repression Required for the Formation and Maintenance of Cancer Stem Cells

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12 December 2020

Paracrine and autocrine signals induce and maintain mesenchymal and stem cell states in the breast

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12 December 2020

Identification of human brain tumour initiating cells

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12 December 2020

Bmi1 is essential in Twist1-induced epithelial–mesenchymal transition

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12 December 2020

Induction by transforming growth factor-beta1 of epithelial to mesenchymal transition is a rare event in vitro

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12 December 2020

A Wnt-Axin2-GSK3beta cascade regulates Snail1 activity in breast cancer cells

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12 December 2020

TGF-beta1 and Ha-Ras collaborate in modulating the phenotypic plasticity and invasiveness of epithelial tumor cells

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12 December 2020

Wnt signaling in stem and cancer stem cells

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12 December 2020

DeltaEF1 is a transcriptional repressor of E-cadherin and regulates epithelial plasticity in breast cancer cells

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12 December 2020

Identification and expansion of human colon-cancer-initiating cells

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12 December 2020

Twist is a potential oncogene that inhibits apoptosis

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12 December 2020

Glycogen synthase kinase 3 β-dependent Snail degradation directs hepatocyte proliferation in normal liver regeneration.

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12 December 2020

Cancer stem cells: back to Darwin?

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12 December 2020

Upregulation of Twist-1 by NF-kappaB blocks cytotoxicity induced by chemotherapeutic drugs

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12 December 2020

Mechanisms, mechanics and function of epithelial-mesenchymal transitions in early development

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12 December 2020

The transcription factor Slug represses E-cadherin expression and induces epithelial to mesenchymal transitions: a comparison with Snail and E47 repressors

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12 December 2020

Moving Targets That Drive Cancer Progression

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12 December 2020

Metastatic colonization: settlement, adaptation and propagation of tumor cells in a foreign tissue environment

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12 December 2020

Generation of breast cancer stem cells through epithelial-mesenchymal transition

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12 December 2020

Synergistic principles of development: overlapping patterning systems in Xenopus mesoderm induction

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12 December 2020

Comment on "Tumor growth need not be driven by rare cancer stem cells".

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12 December 2020

Prospective identification of tumorigenic breast cancer cells

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12 December 2020

Invasion and metastasis in colorectal cancer: epithelial-mesenchymal transition, mesenchymal-epithelial transition, stem cells and beta-catenin

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12 December 2020

Epigenetic inactivation of secreted Frizzled-related proteins in acute myeloid leukaemia

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12 December 2020

Epithelial-mesenchymal transitions: the importance of changing cell state in development and disease.

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12 December 2020

Polycomb complex 2 is required for E-cadherin repression by the Snail1 transcription factor.

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12 December 2020

Metastasis mechanisms

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12 December 2020

Snail activation disrupts tissue homeostasis and induces fibrosis in the adult kidney

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12 December 2020

BMP-7 counteracts TGF-beta1-induced epithelial-to-mesenchymal transition and reverses chronic renal injury

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12 December 2020

Direct regulation of TWIST by HIF-1alpha promotes metastasis

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12 December 2020

Zinc-finger transcription factor slug contributes to the survival advantage of chronic myeloid leukemia cells

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12 December 2020

10.1016/J.SEMCANCER.2012.04.001

Identifiers

DOI

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1 July 2019

PMC publication ID

6220425

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1 July 2019

PubMed publication ID

22554795

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1 July 2019