(Q90675087)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30065630%20AND%20SRC:MED&resulttype=core&format=json

15 April 2020

title

Novel Nrf2-Inducer Prevents Mitochondrial Defects and Oxidative Stress in Friedreich's Ataxia Models (English)

1 reference

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15 April 2020

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4

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15 April 2020

author name string

Rosella Abeti

series ordinal

1

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30065630%20AND%20SRC:MED&resulttype=core&format=json

15 April 2020

Annalisa Baccaro

series ordinal

2

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30065630%20AND%20SRC:MED&resulttype=core&format=json

15 April 2020

Noemi Esteras

series ordinal

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30065630%20AND%20SRC:MED&resulttype=core&format=json

15 April 2020

publication date

17 July 2018

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30065630%20AND%20SRC:MED&resulttype=core&format=json

Frontiers in Cellular Neuroscience

15 April 2020

published in

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15 April 2020

volume

12

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15 April 2020

page(s)

188

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Creative Commons Attribution 4.0 International

15 April 2020

copyright license

start time

17 July 2018

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

cites work

Friedreich's ataxia: autosomal recessive disease caused by an intronic GAA triplet repeat expansion

1 reference

12 December 2020

beta 25-35 alters calcium homeostasis and induces neurotoxicity in cerebellar granule cells

1 reference

12 December 2020

Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain

1 reference

12 December 2020

The yeast frataxin homologue mediates mitochondrial iron efflux. Evidence for a mitochondrial iron cycle

1 reference

12 December 2020

Iron use for haeme synthesis is under control of the yeast frataxin homologue (Yfh1).

1 reference

12 December 2020

Neurodegenerative diseases and oxidative stress

1 reference

12 December 2020

GAA repeat expansion mutation mouse models of Friedreich ataxia exhibit oxidative stress leading to progressive neuronal and cardiac pathology

1 reference

12 December 2020

Friedreich's ataxia: coenzyme Q10 and vitamin E therapy

1 reference

12 December 2020

Coenzyme Q10 and vitamin E deficiency in Friedreich's ataxia: predictor of efficacy of vitamin E and coenzyme Q10 therapy.

1 reference

12 December 2020

Impaired nuclear Nrf2 translocation undermines the oxidative stress response in Friedreich ataxia

1 reference

12 December 2020

Molecular control of the cytosolic aconitase/IRP1 switch by extramitochondrial frataxin

1 reference

12 December 2020

PGC-1alpha down-regulation affects the antioxidant response in Friedreich's ataxia

1 reference

12 December 2020

Beta-amyloid activates PARP causing astrocytic metabolic failure and neuronal death

1 reference

12 December 2020

Frataxin deficiency leads to defects in expression of antioxidants and Nrf2 expression in dorsal root ganglia of the Friedreich's ataxia YG8R mouse model

1 reference

12 December 2020

Clinical features of Friedreich's ataxia: classical and atypical phenotypes.

1 reference

12 December 2020

Topical application of the synthetic triterpenoid RTA 408 activates Nrf2 and induces cytoprotective genes in rat skin

1 reference

12 December 2020

Hrd1 suppresses Nrf2-mediated cellular protection during liver cirrhosis

1 reference

12 December 2020

Mitochondrial reactive oxygen species production and elimination

1 reference

12 December 2020

Topical application of the synthetic triterpenoid RTA 408 protects mice from radiation-induced dermatitis

1 reference

12 December 2020

Dysregulation of cellular iron metabolism in Friedreich ataxia: from primary iron-sulfur cluster deficit to mitochondrial iron accumulation.

1 reference

12 December 2020

Measurement of mitochondrial NADH and FAD autofluorescence in live cells.

1 reference

12 December 2020

RTA 408, A Novel Synthetic Triterpenoid with Broad Anticancer and Anti-Inflammatory Activity

1 reference

12 December 2020

Targeting lipid peroxidation and mitochondrial imbalance in Friedreich's ataxia.

1 reference

12 December 2020

Topical application of RTA 408 lotion activates Nrf2 in human skin and is well-tolerated by healthy human volunteers

1 reference

12 December 2020

The spatiotemporal regulation of the Keap1-Nrf2 pathway and its importance in cellular bioenergetics

1 reference

12 December 2020

Nrf2 activation in the treatment of neurodegenerative diseases: a focus on its role in mitochondrial bioenergetics and function

1 reference

12 December 2020

'Mitochondrial energy imbalance and lipid peroxidation cause cell death in Friedreich's ataxia'.

1 reference

12 December 2020

The multifaceted role of Nrf2 in mitochondrial function

1 reference

12 December 2020

Pathogenic p62/SQSTM1 mutations impair energy metabolism through limitation of mitochondrial substrates.

1 reference

12 December 2020

Safety, pharmacokinetics, and pharmacodynamics of oral omaveloxolone (RTA 408), a synthetic triterpenoid, in a first-in-human trial of patients with advanced solid tumors

1 reference

12 December 2020

KEAP1 and Done? Targeting the NRF2 Pathway with Sulforaphane

1 reference

12 December 2020

Targeted Nrf2 activation therapy with RTA 408 enhances regenerative capacity of diabetic wounds.

1 reference

12 December 2020

KEAP1 inhibition is neuroprotective and suppresses the development of epilepsy.

1 reference

12 December 2020

Identifiers

DOI

10.3389/FNCEL.2018.00188

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30065630%20AND%20SRC:MED&resulttype=core&format=json

15 April 2020

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30065630%20AND%20SRC:MED&resulttype=core&format=json

15 April 2020

PubMed publication ID

30065630

1 reference