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The pro-tumorigenic host response to cancer therapies
scientific article published on 23 October 2019
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Europe PubMed Central
PubMed publication ID
31645711
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31645711%20AND%20SRC:MED&resulttype=core&format=json
retrieved
17 April 2020
review article
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Europe PubMed Central
title
The pro-tumorigenic host response to cancer therapies
(English)
1 reference
stated in
Europe PubMed Central
PubMed publication ID
31645711
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31645711%20AND%20SRC:MED&resulttype=core&format=json
retrieved
17 April 2020
author
Yuval Shaked
series ordinal
1
1 reference
stated in
Europe PubMed Central
PubMed publication ID
31645711
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31645711%20AND%20SRC:MED&resulttype=core&format=json
retrieved
17 April 2020
publication date
23 October 2019
1 reference
stated in
Europe PubMed Central
PubMed publication ID
31645711
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31645711%20AND%20SRC:MED&resulttype=core&format=json
retrieved
17 April 2020
published in
Nature Reviews Cancer
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stated in
Europe PubMed Central
PubMed publication ID
31645711
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31645711%20AND%20SRC:MED&resulttype=core&format=json
retrieved
17 April 2020
volume
19
1 reference
stated in
Europe PubMed Central
PubMed publication ID
31645711
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31645711%20AND%20SRC:MED&resulttype=core&format=json
retrieved
17 April 2020
issue
12
1 reference
stated in
Europe PubMed Central
PubMed publication ID
31645711
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31645711%20AND%20SRC:MED&resulttype=core&format=json
retrieved
17 April 2020
page(s)
667-685
1 reference
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Europe PubMed Central
PubMed publication ID
31645711
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31645711%20AND%20SRC:MED&resulttype=core&format=json
retrieved
17 April 2020
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Chemotherapy-Exacerbated Breast Cancer Metastasis: A Paradox Explainable by Dysregulated Adaptive-Response
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1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41568-019-0209-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Multiple circulating proangiogenic factors induced by sunitinib malate are tumor-independent and correlate with antitumor efficacy
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41568-019-0209-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Rapid vascular regrowth in tumors after reversal of VEGF inhibition
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41568-019-0209-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Role of angiopoietin-2 in adaptive tumor resistance to VEGF signaling blockade.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41568-019-0209-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Endothelial cell-derived angiopoietin-2 is a therapeutic target in treatment-naive and bevacizumab-resistant glioblastoma
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41568-019-0209-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Tumor refractoriness to anti-VEGF treatment is mediated by CD11b+Gr1+ myeloid cells.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41568-019-0209-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Bv8 regulates myeloid-cell-dependent tumour angiogenesis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41568-019-0209-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Periostin Limits Tumor Response to VEGFA Inhibition.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41568-019-0209-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Pericyte depletion results in hypoxia-associated epithelial-to-mesenchymal transition and metastasis mediated by met signaling pathway
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41568-019-0209-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Tumor and stromal pathways mediating refractoriness/resistance to anti-angiogenic therapies
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41568-019-0209-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
PDGF-C mediates the angiogenic and tumorigenic properties of fibroblasts associated with tumors refractory to anti-VEGF treatment
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41568-019-0209-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Herceptin down-regulates HER-2/neu and vascular endothelial growth factor expression and enhances taxol-induced cytotoxicity of human Ewing's sarcoma cells in vitro and in vivo.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41568-019-0209-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Tumour biology: herceptin acts as an anti-angiogenic cocktail.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41568-019-0209-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
EGFR regulates the development and microarchitecture of intratumoral angiogenic vasculature capable of sustaining cancer cell intravasation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41568-019-0209-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Cancer surgery induces inflammation, immunosuppression and neo-angiogenesis, but is it influenced by analgesics?
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41568-019-0209-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The effect of surgical wounding on tumour development
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41568-019-0209-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Systemic Effects of Surgery: Quantitative Analysis of Circulating Basic Fibroblast Growth Factor (bFGF), Vascular Endothelial Growth Factor (VEGF) and Transforming Growth Factor Beta (TGF-β) in Patients with Breast Cancer Who Underwent Limited or Ex
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41568-019-0209-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Angiogenic cells, macroparticles and RNA transcripts in laparoscopic vs open surgery for colorectal cancer.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41568-019-0209-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Liver surgery induces an immediate mobilization of progenitor cells in liver cancer patients: A potential role for G-CSF.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41568-019-0209-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Blocking Surgically Induced Lysyl Oxidase Activity Reduces the Risk of Lung Metastases.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41568-019-0209-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Angiogenesis and apoptosis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41568-019-0209-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Hypothesis: Induced angiogenesis after surgery in premenopausal node-positive breast cancer patients is a major underlying reason why adjuvant chemotherapy works particularly well for those patients
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41568-019-0209-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The angiogenic profile of colorectal cancer patients following open or laparoscopic colectomy
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41568-019-0209-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Tumor metastasis: molecular insights and evolving paradigms
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41568-019-0209-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Emerging Biological Principles of Metastasis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41568-019-0209-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Microenvironmental regulation of metastasis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41568-019-0209-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Host response to short-term, single-agent chemotherapy induces matrix metalloproteinase-9 expression and accelerates metastasis in mice
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41568-019-0209-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Chemotherapy Enhances Metastasis Formation via VEGFR-1–Expressing Endothelial Cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41568-019-0209-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Molecular pathways: emerging pathways mediating growth, invasion, and metastasis of tumors progressing in an irradiated microenvironment.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41568-019-0209-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Recruitment of circulating breast cancer cells is stimulated by radiotherapy
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41568-019-0209-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Effects of radiation on metastasis and tumor cell migration
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41568-019-0209-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Macrophages and cathepsin proteases blunt chemotherapeutic response in breast cancer
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41568-019-0209-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Blocking IL1β Pathway Following Paclitaxel Chemotherapy Slightly Inhibits Primary Tumor Growth but Promotes Spontaneous Metastasis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41568-019-0209-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A Unidirectional Transition from Migratory to Perivascular Macrophage Is Required for Tumor Cell Intravasation.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41568-019-0209-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Imaging tumor-stroma interactions during chemotherapy reveals contributions of the microenvironment to resistance
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41568-019-0209-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Heparanase is required for activation and function of macrophages.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41568-019-0209-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Preoperative chemotherapy: updates of National Surgical Adjuvant Breast and Bowel Project Protocols B-18 and B-27.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41568-019-0209-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Measurement of residual breast cancer burden to predict survival after neoadjuvant chemotherapy.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41568-019-0209-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Tumor microenvironment of metastasis and risk of distant metastasis of breast cancer.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41568-019-0209-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A metastasis biomarker (MetaSite Breast™ Score) is associated with distant recurrence in hormone receptor-positive, HER2-negative early-stage breast cancer
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41568-019-0209-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Neoadjuvant chemotherapy induces breast cancer metastasis through a TMEM-mediated mechanism.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41568-019-0209-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Mechanisms of Resistance to Neoadjuvant Chemotherapy in Breast Cancer.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41568-019-0209-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Dequalinium blocks macrophage-induced metastasis following local radiation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41568-019-0209-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Chemotherapy elicits pro-metastatic extracellular vesicles in breast cancer models
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41568-019-0209-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Stress-inducible gene Atf3 in the noncancer host cells contributes to chemotherapy-exacerbated breast cancer metastasis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41568-019-0209-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Hypoxia-induced lysyl oxidase is a critical mediator of bone marrow cell recruitment to form the premetastatic niche
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41568-019-0209-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Accelerated metastasis after short-term treatment with a potent inhibitor of tumor angiogenesis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41568-019-0209-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Peering into the aftermath: The inhospitable host?
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41568-019-0209-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Anti-VEGF therapy induces ECM remodeling and mechanical barriers to therapy in colorectal cancer liver metastases
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41568-019-0209-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Surgery plus chemotherapy compared with surgery alone for localized squamous cell carcinoma of the thoracic esophagus: a Japan Clinical Oncology Group Study--JCOG9204.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41568-019-0209-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Detection of circulating tumor cells as a prognostic factor in patients undergoing radical surgery for non-small-cell lung carcinoma: comparison of the efficacy of the CellSearch Assay™ and the isolation by size of epithelial tumor cell method.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41568-019-0209-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
NSAID analgesic ketorolac used perioperatively may suppress early breast cancer relapse: particular relevance to triple negative subgroup
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41568-019-0209-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The mobilization and recruitment of c-kit+ cells contribute to wound healing after surgery
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41568-019-0209-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Surgery, wound healing, and metastasis: recent insights and clinical implications
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41568-019-0209-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The systemic response to surgery triggers the outgrowth of distant immune-controlled tumors in mouse models of dormancy.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41568-019-0209-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Preoperative stimulation of resolution and inflammation blockade eradicates micrometastases
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41568-019-0209-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The perioperative period is an underutilized window of therapeutic opportunity in patients with colorectal cancer
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41568-019-0209-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Cancer statistics, 2003.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41568-019-0209-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Time distribution of the recurrence risk for breast cancer patients undergoing mastectomy: Further support about the concept of tumor dormancy
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41568-019-0209-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
EMT, CSCs, and drug resistance: the mechanistic link and clinical implications
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41568-019-0209-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Mesenchymal Stem Cells Induce Resistance to Chemotherapy through the Release of Platinum-Induced Fatty Acids
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41568-019-0209-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Therapy-Educated Mesenchymal Stem Cells Enrich for Tumor-Initiating Cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41568-019-0209-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Metronomic chemotherapy prevents therapy-induced stromal activation and induction of tumor-initiating cells.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41568-019-0209-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
CD10+GPR77+ Cancer-Associated Fibroblasts Promote Cancer Formation and Chemoresistance by Sustaining Cancer Stemness
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41568-019-0209-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Tumor-Associated Macrophages Suppress the Cytotoxic Activity of Antimitotic Agents
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41568-019-0209-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Proinflammatory Macrophages Promote Multiple Myeloma Resistance to Bortezomib Therapy
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41568-019-0209-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Cancer-Associated Fibroblasts Promote the Chemo-resistance in Gastric Cancer through Secreting IL-11 Targeting JAK/STAT3/Bcl2 Pathway
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41568-019-0209-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Astrocytes upregulate survival genes in tumor cells and induce protection from chemotherapy
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41568-019-0209-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Adipocytes promote breast cancer resistance to chemotherapy, a process amplified by obesity: role of the major vault protein (MVP)
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41568-019-0209-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Treatment-induced damage to the tumor microenvironment promotes prostate cancer therapy resistance through WNT16B.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41568-019-0209-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Inflammation meets cancer, with NF-κB as the matchmaker
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41568-019-0209-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
NF-κB regulates radioresistance mediated by β1-integrin in three-dimensional culture of breast cancer cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41568-019-0209-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Less is more, regularly: metronomic dosing of cytotoxic drugs can target tumor angiogenesis in mice
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41568-019-0209-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Metronomic chemotherapy: new rationale for new directions
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41568-019-0209-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Metronomic cyclophosphamide regimen selectively depletes CD4+CD25+ regulatory T cells and restores T and NK effector functions in end stage cancer patients
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41568-019-0209-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Evidence Implicating Immunological Host Effects in the Efficacy of Metronomic Low-Dose Chemotherapy
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41568-019-0209-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A multitargeted, metronomic, and maximum-tolerated dose "chemo-switch" regimen is antiangiogenic, producing objective responses and survival benefit in a mouse model of cancer.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41568-019-0209-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Low-dose metronomic combined with intermittent bolus-dose cyclophosphamide is an effective long-term chemotherapy treatment strategy
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41568-019-0209-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Maintenance treatment with capecitabine and bevacizumab in metastatic colorectal cancer (CAIRO3): a phase 3 randomised controlled trial of the Dutch Colorectal Cancer Group.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41568-019-0209-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A pilot study of individualized maximum repeatable dose (iMRD), a new dose finding system, of weekly gemcitabine for patients with metastatic pancreas cancer
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41568-019-0209-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Dose- and time-dependence of the host-mediated response to paclitaxel therapy: a mathematical modeling approach
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41568-019-0209-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Chemotherapeutic Dose Scheduling Based on Tumor Growth Rates Provides a Case for Low-Dose Metronomic High-Entropy Therapies.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41568-019-0209-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Intermittent metronomic drug schedule is essential for activating antitumor innate immunity and tumor xenograft regression
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41568-019-0209-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Anti-VEGF antibody therapy does not promote metastasis in genetically engineered mouse tumour models
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41568-019-0209-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The status of high-dose chemotherapy in breast cancer
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41568-019-0209-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Antiangiogenic strategies on defense: on the possibility of blocking rebounds by the tumor vasculature after chemotherapy
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41568-019-0209-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Normalization of tumor vasculature: an emerging concept in antiangiogenic therapy
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41568-019-0209-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Antiangiogenic therapy: a universal chemosensitization strategy for cancer?
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41568-019-0209-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Phase III study of carboplatin and paclitaxel alone or with sorafenib in advanced non-small-cell lung cancer.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41568-019-0209-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Colony-stimulating factor 1 receptor (CSF1R) inhibitors in cancer therapy
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41568-019-0209-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Macrophage depletion through colony stimulating factor 1 receptor pathway blockade overcomes adaptive resistance to anti-VEGF therapy.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41568-019-0209-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Therapeutic targeting of macrophages enhances chemotherapy efficacy by unleashing type I interferon response
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41568-019-0209-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Macrophages and therapeutic resistance in cancer
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41568-019-0209-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The Selective Tie2 Inhibitor Rebastinib Blocks Recruitment and Function of Tie2Hi Macrophages in Breast Cancer and Pancreatic Neuroendocrine Tumors
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41568-019-0209-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
G-CSF supplementation with chemotherapy can promote revascularization and subsequent tumor regrowth: prevention by a CXCR4 antagonist
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41568-019-0209-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Chemokine receptor CXCR4 expression in colorectal cancer patients increases the risk for recurrence and for poor survival.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41568-019-0209-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Immune-based mechanisms of cytotoxic chemotherapy: implications for the design of novel and rationale-based combined treatments against cancer
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41568-019-0209-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Suppression of chemotherapy-induced cytokine/lipid mediator surge and ovarian cancer by a dual COX-2/sEH inhibitor
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41568-019-0209-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Resolvins suppress tumor growth and enhance cancer therapy.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41568-019-0209-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Cetuximab may inhibit tumor growth and angiogenesis induced by ionizing radiation: a preclinical rationale for maintenance treatment after radiotherapy
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41568-019-0209-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Hyperprogression as a distinct outcome after immunotherapy
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41568-019-0209-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
PD-1 regulatory T cells amplified by PD-1 blockade promote hyperprogression of cancer
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41568-019-0209-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Antibody-Fc/FcR Interaction on Macrophages as a Mechanism for Hyperprogressive Disease in Non-small Cell Lung Cancer Subsequent to PD-1/PD-L1 Blockade
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41568-019-0209-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Immune checkpoint targeting in cancer therapy: toward combination strategies with curative potential
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41568-019-0209-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Avelumab plus Axitinib versus Sunitinib for Advanced Renal-Cell Carcinoma
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41568-019-0209-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Pembrolizumab plus Axitinib versus Sunitinib for Advanced Renal-Cell Carcinoma
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41568-019-0209-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Myeloid-derived suppressor cells: a double-edged sword?
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41568-019-0209-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Tumor cell death and ATP release prime dendritic cells and efficient anticancer immunity
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41568-019-0209-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Chemotherapy response of spontaneous mammary tumors is independent of the adaptive immune system
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41568-019-0209-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Coinhibitory Pathways in Immunotherapy for Cancer
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41568-019-0209-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Combining Immune Checkpoint Inhibitors With Conventional Cancer Therapy
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41568-019-0209-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Immune-modulating properties of ionizing radiation: rationale for the treatment of cancer by combination radiotherapy and immune checkpoint inhibitors
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41568-019-0209-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Immunologic correlates of the abscopal effect in a patient with melanoma
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41568-019-0209-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
State of clinical research of radiotherapy/chemoradiotherapy and immune checkpoint inhibitor therapy combinations in solid tumours-a German radiation oncology survey
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41568-019-0209-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Crosstalk between TEMs and endothelial cells modulates angiogenesis and metastasis via IGF1-IGF1R signalling in epithelial ovarian cancer
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41568-019-0209-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
VEGF inhibits T-cell development and may contribute to tumor-induced immune suppression
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41568-019-0209-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The effect of anti-VEGF therapy on immature myeloid cell and dendritic cells in cancer patients.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41568-019-0209-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Enhancing cancer immunotherapy using antiangiogenics: opportunities and challenges.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41568-019-0209-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Combined antiangiogenic and anti-PD-L1 therapy stimulates tumor immunity through HEV formation.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41568-019-0209-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Sex and interleukin-6 are prognostic factors for autoimmune toxicity following treatment with anti-CTLA4 blockade.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41568-019-0209-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Combined Blockade of IL6 and PD-1/PD-L1 Signaling Abrogates Mutual Regulation of Their Immunosuppressive Effects in the Tumor Microenvironment
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41568-019-0209-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Targeting Interleukin-6 (IL-6) Sensitizes Anti-PD-L1 Treatment in a Colorectal Cancer Preclinical Model
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41568-019-0209-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Effects of BRAF mutations and BRAF inhibition on immune responses to melanoma
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41568-019-0209-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Immune Responses to Epidermal Growth Factor Receptor (EGFR) and Their Application for Cancer Treatment
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41568-019-0209-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Reversing EGFR Mediated Immunoescape by Targeted Monoclonal Antibody Therapy
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41568-019-0209-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Comprehensive Clinical Trial Data Summation for BRAF-MEK Inhibition and Checkpoint Immunotherapy in Metastatic Melanoma
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41568-019-0209-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
High-dimensional single-cell analysis predicts response to anti-PD-1 immunotherapy
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41568-019-0209-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Cancer immunotherapy: Strategies for personalization and combinatorial approaches
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41568-019-0209-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Macrophage targeting: opening new possibilities for cancer immunotherapy
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41568-019-0209-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
CSF1/CSF1R blockade reprograms tumor-infiltrating macrophages and improves response to T-cell checkpoint immunotherapy in pancreatic cancer models.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41568-019-0209-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Combinatorial drug therapy for cancer in the post-genomic era.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41568-019-0209-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Pooled Analysis of Long-Term Survival Data From Phase II and Phase III Trials of Ipilimumab in Unresectable or Metastatic Melanoma
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41568-019-0209-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Rationalizing combination therapies
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41568-019-0209-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identifiers
DOI
10.1038/S41568-019-0209-6
1 reference
stated in
Europe PubMed Central
PubMed publication ID
31645711
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31645711%20AND%20SRC:MED&resulttype=core&format=json
retrieved
17 April 2020
PubMed publication ID
31645711
1 reference
stated in
Europe PubMed Central
PubMed publication ID
31645711
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31645711%20AND%20SRC:MED&resulttype=core&format=json
retrieved
17 April 2020
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