(Q91588247)

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Preclinical Evidence of STAT3 Inhibitor Pacritinib Overcoming Temozolomide Resistance via Downregulating miR-21-Enriched Exosomes from M2 Glioblastoma-Associated Macrophages

scientific article published on 02 July 2019

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scholarly article

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23 April 2020

Preclinical Evidence of STAT3 Inhibitor Pacritinib Overcoming Temozolomide Resistance via Downregulating miR-21-Enriched Exosomes from M2 Glioblastoma-Associated Macrophages (English)

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23 April 2020

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Chao-Hsuan Chen

4

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23 April 2020

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23 April 2020

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23 April 2020

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23 April 2020

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Hao-Yu Chuang

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23 April 2020

Yu-Kai Su

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23 April 2020

Heng-Wei Liu

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23 April 2020

Shinn-Zong Lin

7

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23 April 2020

Yueh-Sheng Chen

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23 April 2020

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2 July 2019

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23 April 2020

Journal of Clinical Medicine

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23 April 2020

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23 April 2020

7

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23 April 2020

copyright license

Creative Commons Attribution 4.0 International

2 July 2019

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0 references

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1 reference

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Momelotinib sensitizes glioblastoma cells to temozolomide by enhancement of autophagy via JAK2/STAT3 inhibition

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Exosomes released from tumor-associated macrophages transfer miRNAs that induce a Treg/Th17 cell imbalance in epithelial ovarian cancer

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The critical role that STAT3 plays in glioma-initiating cells: STAT3 addiction in glioma.

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Overexpression of IL-9 induced by STAT3 phosphorylation is mediated by miR-155 and miR-21 in chronic lymphocytic leukemia

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Pacritinib vs Best Available Therapy, Including Ruxolitinib, in Patients With Myelofibrosis: A Randomized Clinical Trial.

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Targeting JAK2 reduces GVHD and xenograft rejection through regulation of T cell differentiation.

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Brain Cortex Microglia Derived Exosomes: novel nanoparticles for glioma therapy

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STAT3-mediated activation of miR-21 is involved in down-regulation of TIMP3 and neovascularization in the ischemic retina

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23 February 2021

The JAK2/STAT3 inhibitor pacritinib effectively inhibits patient-derived GBM brain tumor initiating cells in vitro and when used in combination with temozolomide increases survival in an orthotopic xenograft model

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23 February 2021

Inhibition of Farnesyltransferase Potentiates NOTCH-Targeted Therapy against Glioblastoma Stem Cells.

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The Biology of Cancer Exosomes: Insights and New Perspectives.

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Glioblastoma multiforme-derived extracellular vesicles drive normal astrocytes towards a tumour-enhancing phenotype.

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MiR-21: A key player in glioblastoma pathogenesis.

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The anti-tumor activity of the STAT3 inhibitor STX-0119 occurs via promotion of tumor-infiltrating lymphocyte accumulation in temozolomide-resistant glioblastoma cell line.

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Combination of a STAT3 Inhibitor and an mTOR Inhibitor Against a Temozolomide-resistant Glioblastoma Cell Line

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B7-H4(B7x)-Mediated Cross-talk between Glioma-Initiating Cells and Macrophages via the IL6/JAK/STAT3 Pathway Lead to Poor Prognosis in Glioma Patients

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Glioma Stem Cells and Their Microenvironments: Providers of Challenging Therapeutic Targets

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Concurrent therapy to enhance radiotherapeutic outcomes in glioblastoma

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The role of microglia and macrophages in glioma maintenance and progression

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Effect of the STAT3 inhibitor STX-0119 on the proliferation of a temozolomide-resistant glioblastoma cell line

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Identifiers

10.3390/JCM8070959

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23 April 2020

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23 April 2020

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23 April 2020

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