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Adhesion G Protein-Coupled Receptors as Drug Targets for Neurological Diseases
scientific article published on 11 March 2019
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Europe PubMed Central
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6433515
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29 April 2020
title
Adhesion G Protein-Coupled Receptors as Drug Targets for Neurological Diseases
(English)
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6433515
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29 April 2020
author name string
Christopher J Folts
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1
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29 April 2020
Stefanie Giera
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2
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29 April 2020
Tao Li
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3
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29 April 2020
Xianhua Piao
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4
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29 April 2020
publication date
11 March 2019
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29 April 2020
published in
Trends in Pharmacological Sciences
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29 April 2020
volume
40
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29 April 2020
issue
4
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29 April 2020
page(s)
278-293
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29 April 2020
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23 February 2021
Phosphatidylserine receptor BAI1 and apoptotic cells as new promoters of myoblast fusion
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6433515
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23 February 2021
The adhesion-GPCR BAI1 regulates synaptogenesis by controlling the recruitment of the Par3/Tiam1 polarity complex to synaptic sites
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6433515
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23 February 2021
A genome-wide meta-analysis identifies two novel loci associated with high myopia in the Han Chinese population
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6433515
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23 February 2021
A role for atypical cadherin Celsr3 in hippocampal maturation and connectivity.
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6433515
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23 February 2021
The GPS motif is a molecular switch for bimodal activities of adhesion class G protein-coupled receptors.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6433515
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23 February 2021
A two-locus genetic interaction between LPHN3 and 11q predicts ADHD severity and long-term outcome
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6433515
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23 February 2021
Identification and characterization of three inherited genomic copy number variations associated with familial schizophrenia
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6433515
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23 February 2021
Planar cell polarity genes, Celsr1-3, in neural development
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6433515
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23 February 2021
Signaling property study of adhesion G-protein-coupled receptors
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6433515
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23 February 2021
Initial characterization of mice null for Lphn3, a gene implicated in ADHD and addiction
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6433515
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23 February 2021
The ADHD-susceptibility gene lphn3.1 modulates dopaminergic neuron formation and locomotor activity during zebrafish development.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6433515
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23 February 2021
Role of the planar cell polarity gene CELSR1 in neural tube defects and caudal agenesis
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6433515
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23 February 2021
A novel evolutionarily conserved domain of cell-adhesion GPCRs mediates autoproteolysis
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6433515
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23 February 2021
Disease-associated mutations prevent GPR56-collagen III interaction
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6433515
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23 February 2021
Mechanism and Genotype-Phenotype Correlation of Two Proximal 6q Deletions Characterized Using mBAND, FISH, Array CGH, and DNA Sequencing
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6433515
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23 February 2021
Mutations in the planar cell polarity genes CELSR1 and SCRIB are associated with the severe neural tube defect craniorachischisis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6433515
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23 February 2021
Functional gene group analysis identifies synaptic gene groups as risk factor for schizophrenia.
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6433515
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23 February 2021
GPR56 Regulates VEGF production and angiogenesis during melanoma progression
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6433515
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23 February 2021
Genome-wide association analysis of age at onset in schizophrenia in a European-American sample.
1 reference
stated in
PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6433515
retrieved
23 February 2021
Genetic variants at 13q12.12 are associated with high myopia in the Han Chinese population
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6433515
retrieved
23 February 2021
Gpr126 is essential for peripheral nerve development and myelination in mammals
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6433515
retrieved
23 February 2021
A cooperative interaction between LPHN3 and 11q doubles the risk for ADHD.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6433515
retrieved
23 February 2021
Novel autism subtype-dependent genetic variants are revealed by quantitative trait and subphenotype association analyses of published GWAS data
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6433515
retrieved
23 February 2021
Brain angiogenesis inhibitor 1 (BAI1) is a pattern recognition receptor that mediates macrophage binding and engulfment of Gram-negative bacteria
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6433515
retrieved
23 February 2021
The orphan adhesion-GPCR GPR126 is required for embryonic development in the mouse
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6433515
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23 February 2021
Antidepressant-like behavior in brain-specific angiogenesis inhibitor 2-deficient mice
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6433515
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23 February 2021
Contribution of LPHN3 to the genetic susceptibility to ADHD in adulthood: a replication study.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6433515
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23 February 2021
A genome-wide scan for common alleles affecting risk for autism
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6433515
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23 February 2021
Lack of cadherins Celsr2 and Celsr3 impairs ependymal ciliogenesis, leading to fatal hydrocephalus
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6433515
retrieved
23 February 2021
A common variant of the latrophilin 3 gene, LPHN3, confers susceptibility to ADHD and predicts effectiveness of stimulant medication
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6433515
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23 February 2021
A G protein-coupled receptor is essential for Schwann cells to initiate myelination
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6433515
retrieved
23 February 2021
Splicing variants of the orphan G-protein-coupled receptor GPR56 regulate the activity of transcription factors associated with tumorigenesis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6433515
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23 February 2021
Role of the atypical cadherin Celsr3 during development of the internal capsule.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6433515
retrieved
23 February 2021
Planar polarization in embryonic epidermis orchestrates global asymmetric morphogenesis of hair follicles
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6433515
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23 February 2021
The genetics of symptom-based phenotypes: toward a molecular classification of schizophrenia
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6433515
retrieved
23 February 2021
Early forebrain wiring: genetic dissection using conditional Celsr3 mutant mice
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6433515
retrieved
23 February 2021
BAI1 is an engulfment receptor for apoptotic cells upstream of the ELMO/Dock180/Rac module
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6433515
retrieved
23 February 2021
Hippocampus and amygdala morphology in attention-deficit/hyperactivity disorder
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6433515
retrieved
23 February 2021
The very large G-protein-coupled receptor VLGR1: a component of the ankle link complex required for the normal development of auditory hair bundles.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6433515
retrieved
23 February 2021
GPR56, an atypical G protein-coupled receptor, binds tissue transglutaminase, TG2, and inhibits melanoma tumor growth and metastasis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6433515
retrieved
23 February 2021
Brain development and ADHD
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6433515
retrieved
23 February 2021
The DFNB31 gene product whirlin connects to the Usher protein network in the cochlea and retina by direct association with USH2A and VLGR1
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6433515
retrieved
23 February 2021
Protocadherin Celsr3 is crucial in axonal tract development
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6433515
retrieved
23 February 2021
The human and mouse repertoire of the adhesion family of G-protein-coupled receptors
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6433515
retrieved
23 February 2021
G protein-coupled receptor-dependent development of human frontal cortex
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6433515
retrieved
23 February 2021
Mutations in the VLGR1 gene implicate G-protein signaling in the pathogenesis of Usher syndrome type II
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6433515
retrieved
23 February 2021
Mutation of Celsr1 disrupts planar polarity of inner ear hair cells and causes severe neural tube defects in the mouse
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6433515
retrieved
23 February 2021
The atypical cadherin Flamingo links Frizzled and Notch signaling in planar polarity establishment in the Drosophila eye.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6433515
retrieved
23 February 2021
Identifiers
DOI
10.1016/J.TIPS.2019.02.003
1 reference
stated in
Europe PubMed Central
PMC publication ID
6433515
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30871735%20AND%20SRC:MED&resulttype=core&format=json
retrieved
29 April 2020
PMC publication ID
6433515
1 reference
stated in
Europe PubMed Central
PMC publication ID
6433515
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30871735%20AND%20SRC:MED&resulttype=core&format=json
retrieved
29 April 2020
PubMed publication ID
30871735
1 reference
stated in
Europe PubMed Central
PMC publication ID
6433515
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30871735%20AND%20SRC:MED&resulttype=core&format=json
retrieved
29 April 2020
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