(Q93138971)

English

A phase Ib dose-finding, pharmacokinetic study of the focal adhesion kinase inhibitor GSK2256098 and trametinib in patients with advanced solid tumours

scientific article published on 17 April 2019

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scholarly article

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30992546%20AND%20SRC:MED&resulttype=core&format=json

3 May 2020

A phase Ib dose-finding, pharmacokinetic study of the focal adhesion kinase inhibitor GSK2256098 and trametinib in patients with advanced solid tumours (English)

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30992546%20AND%20SRC:MED&resulttype=core&format=json

3 May 2020

pharmacokinetics

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based on heuristic

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Gabriel Mak

1

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3 May 2020

Jean-Charles Soria

2

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3 May 2020

Sarah P Blagden

3

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3 May 2020

Ruth Plummer

4

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3 May 2020

Ronald A Fleming

5

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3 May 2020

Noelia Nebot

6

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3 May 2020

Jianping Zhang

7

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3 May 2020

Jolly Mazumdar

8

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3 May 2020

Debra Rogan

9

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3 May 2020

Anas Gazzah

10

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3 May 2020

Ivana Rizzuto

11

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3 May 2020

Alastair Greystoke

12

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3 May 2020

Li Yan

13

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3 May 2020

Jerry Tolson

14

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3 May 2020

Kurt R Auger

15

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3 May 2020

Hendrik-Tobias Arkenau

16

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3 May 2020

publication date

17 April 2019

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3 May 2020

British Journal of Cancer

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3 May 2020

120

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3 May 2020

10

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3 May 2020

975-981

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3 May 2020

copyright license

Creative Commons Attribution 4.0 International

17 April 2019

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April 2022 Public Data File from Crossref

copyright status

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A phase I, pharmacokinetic and pharmacodynamic study of GSK2256098, a focal adhesion kinase inhibitor, in patients with advanced solid tumors.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6735221

11 February 2021

Low Merlin expression and high Survivin labeling index are indicators for poor prognosis in patients with malignant pleural mesothelioma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6735221

11 February 2021

Dabrafenib and trametinib versus dabrafenib and placebo for Val600 BRAF-mutant melanoma: a multicentre, double-blind, phase 3 randomised controlled trial

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6735221

11 February 2021

Overexpression of activin-A and -B in malignant mesothelioma - attenuated Smad3 signaling responses and ERK activation promote cell migration and invasive growth.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6735221

11 February 2021

Safety, pharmacokinetic, pharmacodynamic, and efficacy data for the oral MEK inhibitor trametinib: a phase 1 dose-escalation trial

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6735221

11 February 2021

Phosphorylation of focal adhesion kinase at Tyr397 in gastric carcinomas and its clinical significance

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6735221

11 February 2021

New response evaluation criteria in solid tumours: revised RECIST guideline (version 1.1)

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6735221

11 February 2021

Re-expression of the tumor suppressor NF2/merlin inhibits invasiveness in mesothelioma cells and negatively regulates FAK.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6735221

11 February 2021

Phosphorylated extracellular signal-regulated kinases are significantly increased in malignant mesothelioma.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6735221

11 February 2021

The role of focal-adhesion kinase in cancer - a new therapeutic opportunity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6735221

11 February 2021

Mitogen-activated protein kinase expression and activation does not differentiate benign from malignant mesothelial cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6735221

11 February 2021

Biological significance of focal adhesion kinase in ovarian cancer: role in migration and invasion

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6735221

11 February 2021

Expression of focal adhesion kinase in acute myeloid leukemia is associated with enhanced blast migration, increased cellularity, and poor prognosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6735221

11 February 2021

Modified RECIST criteria for assessment of response in malignant pleural mesothelioma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6735221

11 February 2021

Immunohistochemical analyses of focal adhesion kinase expression in benign and malignant human breast and colon tissues: correlation with preinvasive and invasive phenotypes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6735221

11 February 2021

Identifiers

10.1038/S41416-019-0452-3

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30992546%20AND%20SRC:MED&resulttype=core&format=json

3 May 2020

PMC publication ID

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30992546%20AND%20SRC:MED&resulttype=core&format=json

3 May 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30992546%20AND%20SRC:MED&resulttype=core&format=json

3 May 2020

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