(Q112189007)

English

Combining Activity Profiling with Advanced Annotation to Accelerate the Discovery of Natural Products Targeting Oncogenic Signaling in Melanoma

scientific article published on 31 May 2022

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scholarly article

1 reference

31 May 2022

Combining Activity Profiling with Advanced Annotation to Accelerate the Discovery of Natural Products Targeting Oncogenic Signaling in Melanoma (English)

1 reference

31 May 2022

Swiss National Science Foundation

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Swiss Cancer League

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natural product

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Hyptis brevipes

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Artemisia argyi

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Hyptis brachiata

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1 reference

1 reference

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chrysosplenol C

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6-methoxytricin

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0 references

1 reference

chrysosplenetin

1 reference

1 reference

3',4',5,6-tetrahydroxy-3,7-dimethoxyflavone

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sideritoflavone

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object named as

Adriano Rutz

2

1 reference

31 May 2022

Maciej Dobrzyński

object named as

Maciej Dobrzyński

4

1 reference

31 May 2022

Matthias Hamburger

object named as

Matthias Hamburger

11

1 reference

31 May 2022

Jean-Luc Wolfender

object named as

Jean-Luc Wolfender

12

1 reference

31 May 2022

1

object named as

Tanja Hell

1 reference

31 May 2022

3

object named as

Lara Dürr

1 reference

31 May 2022

Jakob K. Reinhardt

5

object named as

Jakob K. Reinhardt

1 reference

31 May 2022

9

object named as

Mahabir Gupta

1 reference

31 May 2022

10

object named as

Olivier Pertz

1 reference

31 May 2022

7

object named as

Morris Keller

1 reference

31 May 2022

13

object named as

Eliane Garo

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31 May 2022

author name string

Timo Lehner

6

1 reference

31 May 2022

Anika John

8

1 reference

31 May 2022

language of work or name

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31 May 2022

publication date

31 May 2022

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31 May 2022

number of pages

15

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Journal of Natural Products

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31 May 2022

85

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11

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copyright status

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describes a project that uses

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ThermoRawFileParser

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NMR spectroscopy

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liquid chromatography–mass spectrometry

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online access status

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Mitchell P Levesque

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access restriction status

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Sharing and community curation of mass spectrometry data with Global Natural Products Social Molecular Networking

1 reference

https://opencitations.net/index/coci/api/v1/references/10.1021/ACS.JNATPROD.2C00146

31 August 2022

SpecDis: quantifying the comparison of calculated and experimental electronic circular dichroism spectra.

1 reference

https://opencitations.net/index/coci/api/v1/references/10.1021/ACS.JNATPROD.2C00146

31 August 2022

Co-existence of BRAF and NRAS driver mutations in the same melanoma cells results in heterogeneity of targeted therapy resistance.

1 reference

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31 August 2022

Biological and pharmacological activities and further constituents of Hyptis verticillata

1 reference

https://opencitations.net/index/coci/api/v1/references/10.1021/ACS.JNATPROD.2C00146

31 August 2022

MassBank: a public repository for sharing mass spectral data for life sciences

1 reference

https://opencitations.net/index/coci/api/v1/references/10.1021/ACS.JNATPROD.2C00146

31 August 2022

Sesquiterpene Lactones from Artemisia argyi: Absolute Configuration and Immunosuppressant Activity

1 reference

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31 August 2022

The (+)-Brevipolide H Displays Anticancer Activity against Human Castration-Resistant Prostate Cancer: The Role of Oxidative Stress and Akt/mTOR/p70S6K-Dependent Pathways in G1 Checkpoint Arrest and Apoptosis

1 reference

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31 August 2022

Combined use of extract libraries and HPLC-based activity profiling for lead discovery: potential, challenges, and practical considerations

1 reference

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31 August 2022

Flavonol and Coumarin Glycosides from Artemisia incanescens

1 reference

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31 August 2022

NPClassifier: A Deep Neural Network-Based Structural Classification Tool for Natural Products

1 reference

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31 August 2022

Antimutagens in gaiyou (Artemisia argyi levl. et vant.).

1 reference

https://opencitations.net/index/coci/api/v1/references/10.1021/ACS.JNATPROD.2C00146

31 August 2022

NMR of natural products at the 'nanomole-scale'.

1 reference

https://opencitations.net/index/coci/api/v1/references/10.1021/ACS.JNATPROD.2C00146

31 August 2022

Systematic classification of unknown metabolites using high-resolution fragmentation mass spectra

1 reference

https://opencitations.net/index/coci/api/v1/references/10.1021/ACS.JNATPROD.2C00146

31 August 2022

Homogentisic acid derivatives from Miliusa balansae

1 reference

https://opencitations.net/index/coci/api/v1/references/10.1021/ACS.JNATPROD.2C00146

31 August 2022

Bioactive constituents of Chinese natural medicines. I. New sesquiterpene ketones with vasorelaxant effect from Chinese moxa, the processed leaves of Artemisia argyi Levl. et Vant.: moxartenone and moxartenolide

1 reference

https://opencitations.net/index/coci/api/v1/references/10.1021/ACS.JNATPROD.2C00146

31 August 2022

Cytoscape: a software environment for integrated models of biomolecular interaction networks

1 reference

https://opencitations.net/index/coci/api/v1/references/10.1021/ACS.JNATPROD.2C00146

31 August 2022

Antiviral Compounds from Codiaeum peltatum Targeted by a Multi-informative Molecular Networks Approach

1 reference

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31 August 2022

Feature-Based Molecular Networking for the Targeted Identification of G<sub>q</sub>-Inhibiting FR900359 Derivatives

1 reference

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31 August 2022

Eupatilin, a major flavonoid of Artemisia, attenuates aortic smooth muscle cell proliferation and migration by inhibiting PI3K, MKK3/6, and MKK4 activities

1 reference

https://opencitations.net/index/coci/api/v1/references/10.1021/ACS.JNATPROD.2C00146

31 August 2022

Multiplexed Fluorescence Imaging of ERK and Akt Activities and Cell-cycle Progression.

1 reference

https://opencitations.net/index/coci/api/v1/references/10.1021/ACS.JNATPROD.2C00146

31 August 2022

Bioactivity-Based Molecular Networking for the Discovery of Drug Leads in Natural Product Bioassay-Guided Fractionation.

1 reference

https://opencitations.net/index/coci/api/v1/references/10.1021/ACS.JNATPROD.2C00146

31 August 2022

Current approaches and challenges for the metabolite profiling of complex natural extracts

1 reference

https://opencitations.net/index/coci/api/v1/references/10.1021/ACS.JNATPROD.2C00146

31 August 2022

Cytotoxic constituents from Hyptis verticillata

1 reference

https://opencitations.net/index/coci/api/v1/references/10.1021/ACS.JNATPROD.2C00146

31 August 2022

Molecular Networking As a Drug Discovery, Drug Metabolism, and Precision Medicine Strategy

1 reference

https://opencitations.net/index/coci/api/v1/references/10.1021/ACS.JNATPROD.2C00146

31 August 2022

Tricyclic diterpenes from hyptys dilatata

1 reference

https://opencitations.net/index/coci/api/v1/references/10.1021/ACS.JNATPROD.2C00146

31 August 2022

Complementarity of DFT Calculations, NMR Anisotropy, and ECD for the Configurational Analysis of Brevipolides K-O from Hyptis brevipes.

1 reference

https://opencitations.net/index/coci/api/v1/references/10.1021/ACS.JNATPROD.2C00146

31 August 2022

Integration of Molecular Networking and In-Silico MS/MS Fragmentation for Natural Products Dereplication.

1 reference

https://opencitations.net/index/coci/api/v1/references/10.1021/ACS.JNATPROD.2C00146

31 August 2022

Flavonoids from Artemisia ludoviciana var. ludoviciana

1 reference

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31 August 2022

Three new compounds from the plant Lippia alva as inhibitors of chemokine receptor 5 (CCR5).

1 reference

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31 August 2022

Screening of Inhibitory Effects of Polyphenols on Akt-Phosphorylation in Endothelial Cells and Determination of Structure-Activity Features

1 reference

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31 August 2022

Natural product libraries: assembly, maintenance, and screening

1 reference

https://opencitations.net/index/coci/api/v1/references/10.1021/ACS.JNATPROD.2C00146

31 August 2022

Innovative omics-based approaches for prioritisation and targeted isolation of natural products - new strategies for drug discovery

1 reference

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31 August 2022

Can Invalid Bioactives Undermine Natural Product-Based Drug Discovery?

1 reference

https://opencitations.net/index/coci/api/v1/references/10.1021/ACS.JNATPROD.2C00146

31 August 2022

Creating and screening natural product libraries

1 reference

https://opencitations.net/index/coci/api/v1/references/10.1021/ACS.JNATPROD.2C00146

31 August 2022

Bioactive 5,6-dihydro-alpha-pyrone derivatives from Hyptis brevipes

1 reference

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31 August 2022

Ion identity molecular networking for mass spectrometry-based metabolomics in the GNPS environment

1 reference

https://opencitations.net/index/coci/api/v1/references/10.1021/ACS.JNATPROD.2C00146

31 August 2022

Flavonoids of Artemisia argyi

1 reference

https://opencitations.net/index/coci/api/v1/references/10.1021/ACS.JNATPROD.2C00146

31 August 2022

Phenolic and acetylenic metabolites from Artemisia assoana

1 reference

https://opencitations.net/index/coci/api/v1/references/10.1021/ACS.JNATPROD.2C00146

31 August 2022

High-confidence structural annotation of metabolites absent from spectral libraries

2 references

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31 August 2022

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31 August 2022

High-sensitivity measurements of multiple kinase activities in live single cells

1 reference

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31 August 2022

ThermoRawFileParser: Modular, Scalable, and Cross-Platform RAW File Conversion

1 reference

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31 August 2022

Absolute configuration and conformational analysis of brevipolides, bioactive 5,6-dihydro-α-pyrones from Hyptis brevipes

1 reference

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31 August 2022

Advances in decomposing complex metabolite mixtures using substructure- and network-based computational metabolomics approaches

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31 August 2022

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Integration of micro-fractionation, high-performance liquid chromatography-ultraviolet detector-charged aerosol detector-mass spectrometry analysis and cellular dynamic mass redistribution assay to accelerate alkaloid drug discovery

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31 August 2022

A Detailed Investigation and Comparison of the XCMS and MZmine 2 Chromatogram Construction and Chromatographic Peak Detection Methods for Preprocessing Mass Spectrometry Metabolomics Data

1 reference

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31 August 2022

Taxonomically Informed Scoring Enhances Confidence in Natural Products Annotation

2 references

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31 August 2022

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1 reference

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31 August 2022

Jaceosidin, a pharmacologically active flavone derived from Artemisia argyi, inhibits phorbol-ester-induced upregulation of COX-2 and MMP-9 by blocking phosphorylation of ERK-1 and -2 in cultured human mammary epithelial cells

1 reference

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Evolution of secondary metabolites from an ecological and molecular phylogenetic perspective

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Antitumor activity of flavones isolated from Artemisia argyi

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Inhibitory effect of jaceosidin isolated from Artemisiaargyi on the function of E6 and E7 oncoproteins of HPV 16.

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5 December 2022

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10.1021/ACS.JNATPROD.2C00146

1 reference

31 May 2022

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ae0c6ec93b89bc8b239498d354d686cc1a37c019

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