Wikidata

(Q21116494)

English

Heat shock protein family A (Hsp70) member 5

mammalian protein found in Homo sapiens

  • immunoglobulin heavy chain-binding protein
  • BiP
  • 78 kDa glucose-regulated protein
  • glucose-regulated protein, 78kDa
  • binding-immunoglobulin protein
  • endoplasmic reticulum lumenal Ca(2+)-binding protein grp78
  • heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
  • epididymis secretory sperm binding protein Li 89n
  • HSP70 family protein 5
  • Heat shock 70 kDa protein 5
  • heat shock protein family A member 5
  • heat shock protein 70 family protein 5
  • endoplasmic reticulum chaperone BiP
  • HSPA5
In more languages

Statements

molecular function
protein binding
determination method
IPI
25 references
retrieved
8 April 2019
stated in
Role of the lectin VIP36 in post-ER quality control of human alpha1-antitrypsin
GOA
curator
UniProt
UniProt protein ID
P11021
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11021
determination method
IPI
retrieved
8 April 2019
stated in
GRP78 regulates clusterin stability, retrotranslocation and mitochondrial localization under ER stress in prostate cancer
GOA
curator
UniProt
UniProt protein ID
P11021
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11021
determination method
IPI
retrieved
8 April 2019
stated in
A newly uncovered group of distantly related lysine methyltransferases preferentially interact with molecular chaperones to regulate their activity
GOA
curator
UniProt
UniProt protein ID
P11021
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11021
determination method
IPI
retrieved
8 April 2019
stated in
Dimerization and release of molecular chaperone inhibition facilitate activation of eukaryotic initiation factor-2 kinase in response to endoplasmic reticulum stress
GOA
curator
UniProt
UniProt protein ID
P11021
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11021
determination method
IPI
retrieved
8 April 2019
stated in
OS-9 and GRP94 deliver mutant alpha1-antitrypsin to the Hrd1-SEL1L ubiquitin ligase complex for ERAD
GOA
curator
UniProt
UniProt protein ID
P11021
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11021
determination method
IPI
retrieved
8 April 2019
stated in
Unraveling the role of KIAA1199, a novel endoplasmic reticulum protein, in cancer cell migration
GOA
curator
UniProt
UniProt protein ID
P11021
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11021
determination method
IPI
retrieved
8 April 2019
stated in
ERdj5 is the ER reductase that catalyzes the removal of non-native disulfides and correct folding of the LDL receptor
GOA
curator
UniProt
UniProt protein ID
P11021
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11021
determination method
IPI
retrieved
8 April 2019
stated in
Dimerization of pro-oncogenic protein Anterior Gradient 2 is required for the interaction with BiP/GRP78
GOA
curator
UniProt
UniProt protein ID
P11021
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11021
determination method
IPI
retrieved
8 April 2019
stated in
A novel link between Fic (filamentation induced by cAMP)-mediated adenylylation/AMPylation and the unfolded protein response
GOA
curator
UniProt
UniProt protein ID
P11021
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11021
determination method
IPI
retrieved
8 April 2019
stated in
Human XTP3-B forms an endoplasmic reticulum quality control scaffold with the HRD1-SEL1L ubiquitin ligase complex and BiP
GOA
curator
UniProt
UniProt protein ID
P11021
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11021
determination method
IPI
retrieved
8 April 2019
stated in
GRP78 and Raf-1 cooperatively confer resistance to endoplasmic reticulum stress-induced apoptosis
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11021
determination method
IPI
retrieved
8 April 2019
stated in
The Salmonella type III secretion effector, salmonella leucine-rich repeat protein (SlrP), targets the human chaperone ERdj3
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11021
determination method
IPI
retrieved
8 April 2019
stated in
Histone Interaction Landscapes Visualized by Crosslinking Mass Spectrometry in Intact Cell Nuclei
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11021
determination method
IPI
retrieved
8 April 2019
stated in
Compounds Triggering ER Stress Exert Anti-Melanoma Effects and Overcome BRAF Inhibitor Resistance
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11021
determination method
IPI
retrieved
8 April 2019
stated in
Perturbation of the mutated EGFR interactome identifies vulnerabilities and resistance mechanisms
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11021
determination method
IPI
retrieved
8 April 2019
stated in
Dimerization and release of molecular chaperone inhibition facilitate activation of eukaryotic initiation factor-2 kinase in response to endoplasmic reticulum stress
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11021
determination method
IPI
retrieved
8 April 2019
stated in
IRE1α is an endogenous substrate of endoplasmic-reticulum-associated degradation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11021
determination method
IPI
retrieved
8 April 2019
stated in
A human interactome in three quantitative dimensions organized by stoichiometries and abundances
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11021
determination method
IPI
retrieved
8 April 2019
stated in
BiP-mediated closing of the Sec61 channel limits Ca2+ leakage from the ER
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11021
determination method
IPI
retrieved
8 April 2019
stated in
Identification of a potential tumor differentiation factor receptor candidate in prostate cancer cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11021
determination method
IPI
retrieved
8 April 2019
stated in
Regulated association of misfolded endoplasmic reticulum lumenal proteins with P58/DNAJc3
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11021
determination method
IPI
retrieved
8 April 2019
stated in
Regulated release of ERdj3 from unfolded proteins by BiP
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11021
determination method
IPI
retrieved
8 April 2019
stated in
Dermokine-β impairs ERK signaling through direct binding to GRP78
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11021
determination method
IPI
retrieved
8 April 2019
stated in
The tumor suppressor Par-4 activates an extrinsic pathway for apoptosis
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11021
determination method
IPI
retrieved
8 April 2019
stated in
Regulation of AKT phosphorylation at Ser473 and Thr308 by endoplasmic reticulum stress modulates substrate specificity in a severity dependent manner
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11021
determination method
IPI
cell component
biological process

Identifiers

MeSH descriptor ID
D000091342
subject named as
Endoplasmic Reticulum Chaperone BiP
0 references
PDB structure ID
 
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