(Q21144697)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17032058%20AND%20SRC:MED&resulttype=core&format=json

20 December 2019

title

Lentiviral gene transfer of RPE65 rescues survival and function of cones in a mouse model of Leber congenital amaurosis (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17032058%20AND%20SRC:MED&resulttype=core&format=json

Leber congenital amaurosis

20 December 2019

main subject

congenital disorder

0 references

1 reference

inferred from title

author

Alexis-Pierre Bemelmans

1

object named as

Alexis-Pierre Bemelmans

Alexis-Pierre

Bemelmans

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17032058%20AND%20SRC:MED&resulttype=core&format=json

20 December 2019

2

Corinne Kostic

Corinne

Kostic

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17032058%20AND%20SRC:MED&resulttype=core&format=json

20 December 2019

3

Sylvain V Crippa

Sylvain V

Crippa

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17032058%20AND%20SRC:MED&resulttype=core&format=json

20 December 2019

William W Hauswirth

4

William W

Hauswirth

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17032058%20AND%20SRC:MED&resulttype=core&format=json

20 December 2019

Janis Lem

5

Janis

Lem

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17032058%20AND%20SRC:MED&resulttype=core&format=json

20 December 2019

Francis L Munier

6

Francis L

Munier

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17032058%20AND%20SRC:MED&resulttype=core&format=json

20 December 2019

Mathias W Seeliger

7

Mathias W

Seeliger

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17032058%20AND%20SRC:MED&resulttype=core&format=json

20 December 2019

Andreas Wenzel

8

Andreas

Wenzel

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17032058%20AND%20SRC:MED&resulttype=core&format=json

20 December 2019

Yvan Arsenijevic

9

Yvan

Arsenijevic

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17032058%20AND%20SRC:MED&resulttype=core&format=json

20 December 2019

language of work or name

English

0 references

publication date

1 October 2006

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17032058%20AND%20SRC:MED&resulttype=core&format=json

20 December 2019

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17032058%20AND%20SRC:MED&resulttype=core&format=json

20 December 2019

volume

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17032058%20AND%20SRC:MED&resulttype=core&format=json

20 December 2019

issue

10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17032058%20AND%20SRC:MED&resulttype=core&format=json

20 December 2019

page(s)

e347

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17032058%20AND%20SRC:MED&resulttype=core&format=json

Creative Commons Attribution 4.0 International

20 December 2019

copyright license

start time

10 October 2006

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

cites work

RPE65 is the isomerohydrolase in the retinoid visual cycle

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1592340

Recombinant adeno-associated virus type 2-mediated gene delivery into the Rpe65-/- knockout mouse eye results in limited rescue

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1592340

Mutations in RPE65 cause autosomal recessive childhood-onset severe retinal dystrophy

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1592340

Rpe65 is the retinoid isomerase in bovine retinal pigment epithelium

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1592340

Leber congenital amaurosis: comprehensive survey of the genetic heterogeneity, refinement of the clinical definition, and genotype-phenotype correlations as a strategy for molecular diagnosis

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1592340

Phototransduction in transgenic mice after targeted deletion of the rod transducin alpha -subunit

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1592340

Phenotype of three consanguineous Tunisian families with early-onset retinal degeneration caused by an R91W homozygous mutation in the RPE65 gene

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1592340

Effective gene therapy with nonintegrating lentiviral vectors

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1592340

Long-term restoration of rod and cone vision by single dose rAAV-mediated gene transfer to the retina in a canine model of childhood blindness

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1592340

Mutation of key residues of RPE65 abolishes its enzymatic role as isomerohydrolase in the visual cycle.

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1592340

Adeno-associated virus-vectored gene therapy for retinal disease

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1592340

Downregulation of cone-specific gene expression and degeneration of cone photoreceptors in the Rpe65-/- mouse at early ages

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1592340

Dark adaptation and the retinoid cycle of vision

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1592340

Pars plana vitrectomy, subretinal injection of tissue plasminogen activator, and fluid-gas exchange for displacement of thick submacular hemorrhage in age-related macular degeneration

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1592340

Woodchuck hepatitis virus posttranscriptional regulatory element enhances expression of transgenes delivered by retroviral vectors.

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1592340

Stable and efficient gene transfer into the retina using an HIV-based lentiviral vector

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1592340

Efficient photoreceptor-targeted gene expression in vivo by recombinant adeno-associated virus

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1592340

Activity analysis of housekeeping promoters using self-inactivating lentiviral vector delivery into the mouse retina.

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1592340

Five recombinant simian immunodeficiency virus pseudotypes lead to exclusive transduction of retinal pigmented epithelium in rat.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1592340

Ultraviolet and middle wavelength sensitive cone responses in the electroretinogram (ERG) of normal and Rpe65 -/- mice

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1592340

Different functional outcome of RetGC1 and RPE65 gene mutations in Leber congenital amaurosis

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1592340

RPE65 gene delivery restores isomerohydrolase activity and prevents early cone loss in Rpe65-/- mice

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1592340

Assessment of structure and function over a 3-year period after gene transfer in RPE65-/- dogs

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1592340

Cone opsin mislocalization in Rpe65-/- mice: a defect that can be corrected by 11-cis retinal

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1592340

Predominant rod photoreceptor degeneration in Leber congenital amaurosis.

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1592340

The retinal G protein-coupled receptor (RGR) enhances isomerohydrolase activity independent of light

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1592340

Long-term preservation of retinal function in the RCS rat model of retinitis pigmentosa following lentivirus-mediated gene therapy

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1592340

In utero gene therapy rescues vision in a murine model of congenital blindness

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1592340

Spontaneous activity of opsin apoprotein is a cause of Leber congenital amaurosis

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1592340

Functional and structural recovery of the retina after gene therapy in the RPE65 null mutation dog.

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1592340

Gene transfer to the nonhuman primate retina with recombinant feline immunodeficiency virus vectors.

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1592340

In vivo gene transfer to the mouse eye using an HIV-based lentiviral vector; efficient long-term transduction of corneal endothelium and retinal pigment epithelium

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1592340

Exchange of surface proteins impacts on viral vector cellular specificity and transduction characteristics: the retina as a model

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1592340

New views on RPE65 deficiency: the rod system is the source of vision in a mouse model of Leber congenital amaurosis.

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1592340

Gene therapy restores vision in a canine model of childhood blindness

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1592340

The murine cone photoreceptor: a single cone type expresses both S and M opsins with retinal spatial patterning

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1592340

Rpe65 is necessary for production of 11-cis-vitamin A in the retinal visual cycle.

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1592340

Real-time, noninvasive in vivo assessment of adeno-associated virus-mediated retinal transduction

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1592340

Gene transfer into the mouse retina mediated by an adeno-associated viral vector

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1592340

Early-onset severe rod-cone dystrophy in young children with RPE65 mutations

29 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/17032058

12 December 2020

inferred from PubMed ID database lookup

HIV-1 genome nuclear import is mediated by a central DNA flap

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/17032058

12 December 2020

inferred from PubMed ID database lookup

Reversible immortalization of human primary cells by lentivector-mediated transfer of specific genes

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/17032058

12 December 2020

inferred from PubMed ID database lookup

Identifiers

DOI

10.1371/JOURNAL.PMED.0030347

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17032058%20AND%20SRC:MED&resulttype=core&format=json

20 December 2019

1 reference

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17032058%20AND%20SRC:MED&resulttype=core&format=json

20 December 2019

PubMed publication ID

17032058

2 references