(Q21496781)

V(D)J recombination-activating protein 1

1 reference

Zinc finger C2H2 superfamily

1 reference

RAG1 importin-binding domain, protein family

1 reference

Zinc finger, RING-type, protein family

1 reference

V(D)J recombination-activating protein 1, Zinc finger, protein family

1 reference

Zinc finger, C3HC4 RING-type, protein family

1 reference

RAG nonamer-binding domain, protein family

1 reference

Zinc finger, RING-type, conserved site, protein family

1 reference

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15919

1 reference

25 May 2022

1 reference

25 May 2022

1 reference

9 May 2019

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15919

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15919

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15919

5 references

9 May 2019

Structure of the RAG1 nonamer binding domain with DNA reveals a dimer that mediates DNA synapsis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15919

9 May 2019

A WW-like module in the RAG1 N-terminal domain contributes to previously unidentified protein-protein interactions

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15919

9 May 2019

Structure of the RAG1 nonamer binding domain with DNA reveals a dimer that mediates DNA synapsis

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15919

9 May 2019

Crystal structure of the V(D)J recombinase RAG1-RAG2

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15919

9 May 2019

Autoinhibition of DNA cleavage mediated by RAG1 and RAG2 is overcome by an epigenetic signal in V(D)J recombination

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15919

ubiquitin protein ligase activity

IPI

5 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15919

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15919

14 February 2019

The RAG1 N-terminal domain is an E3 ubiquitin ligase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15919

14 February 2019

The RING domain of RAG1 ubiquitylates histone H3: a novel activity in chromatin-mediated regulation of V(D)J joining

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15919

14 February 2019

Autoubiquitylation of the V(D)J recombinase protein RAG1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15919

sequence-specific DNA binding

3 references

14 February 2019

Mutations of acidic residues in RAG1 define the active site of the V(D)J recombinase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15919

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15919

14 February 2019

Structure of the RAG1 nonamer binding domain with DNA reveals a dimer that mediates DNA synapsis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15919

protein homodimerization activity

1 reference

9 May 2019

The RING domain of RAG1 ubiquitylates histone H3: a novel activity in chromatin-mediated regulation of V(D)J joining

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15919

3 references

endonuclease activity

4 references

9 May 2019

Structure of the RAG1 nonamer binding domain with DNA reveals a dimer that mediates DNA synapsis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15919

9 May 2019

Mutations of acidic residues in RAG1 define the active site of the V(D)J recombinase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15919

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15919

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15919

ubiquitin-protein transferase activity

3 references

9 May 2019

Autoubiquitylation of the V(D)J recombinase protein RAG1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15919

9 May 2019

The RING domain of RAG1 ubiquitylates histone H3: a novel activity in chromatin-mediated regulation of V(D)J joining

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15919

9 May 2019

The RAG1 N-terminal domain is an E3 ubiquitin ligase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15919

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15919

1 reference

9 May 2019

Crystal structure of the RAG1 dimerization domain reveals multiple zinc-binding motifs including a novel zinc binuclear cluster

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15919

sequence-specific DNA binding

4 references

9 May 2019

Mutations of acidic residues in RAG1 define the active site of the V(D)J recombinase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15919

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15919

9 May 2019

Structure of the RAG1 nonamer binding domain with DNA reveals a dimer that mediates DNA synapsis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15919

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15919

ubiquitin protein ligase activity

6 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15919

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15919

9 May 2019

Autoubiquitylation of the V(D)J recombinase protein RAG1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15919

9 May 2019

The RING domain of RAG1 ubiquitylates histone H3: a novel activity in chromatin-mediated regulation of V(D)J joining

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15919

9 May 2019

The RAG1 N-terminal domain is an E3 ubiquitin ligase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15919

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15919

double-stranded DNA endodeoxyribonuclease activity

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15919

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15919

3 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15919

9 May 2019

Expression and V(D)J recombination activity of mutated RAG-1 proteins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15919

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15919

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

DNA recombinase complex

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15919

endodeoxyribonuclease complex

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15919

1 reference

9 May 2019

TSCOT+ thymic epithelial cell-mediated sensitive CD4 tolerance by direct presentation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15919

negative regulation of T cell apoptotic process

IGI

1 reference

9 May 2019

TSCOT+ thymic epithelial cell-mediated sensitive CD4 tolerance by direct presentation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15919

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15919

HVEM signalling at mucosal barriers provides host defence against pathogenic bacteria

adaptive immune response

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15919

1 reference

9 May 2019

TSCOT+ thymic epithelial cell-mediated sensitive CD4 tolerance by direct presentation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15919

negative regulation of thymocyte apoptotic process

IGI

1 reference

9 May 2019

The BCL2A1 gene as a pre-T cell receptor-induced regulator of thymocyte survival

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15919

regulation of T cell differentiation

IMP

1 reference

9 May 2019

TSCOT+ thymic epithelial cell-mediated sensitive CD4 tolerance by direct presentation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15919

negative regulation of cysteine-type endopeptidase activity involved in apoptotic process

IGI

1 reference

9 May 2019

The BCL2A1 gene as a pre-T cell receptor-induced regulator of thymocyte survival

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15919

8 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15919

14 February 2019

Expression and V(D)J recombination activity of mutated RAG-1 proteins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15919

14 February 2019

RAG-1-deficient mice have no mature B and T lymphocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15919

14 February 2019

Mutations of acidic residues in RAG1 define the active site of the V(D)J recombinase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15919

14 February 2019

The RING domain of RAG1 ubiquitylates histone H3: a novel activity in chromatin-mediated regulation of V(D)J joining

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15919

14 February 2019

RAG-1 and RAG-2, adjacent genes that synergistically activate V(D)J recombination

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15919

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15919

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15919

nucleic acid phosphodiester bond hydrolysis

1 reference

9 May 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15919

histone monoubiquitination

1 reference

14 February 2019

The RING domain of RAG1 ubiquitylates histone H3: a novel activity in chromatin-mediated regulation of V(D)J joining

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15919

protein autoubiquitination

1 reference

9 May 2019

Autoubiquitylation of the V(D)J recombinase protein RAG1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15919

positive regulation of T cell differentiation

1 reference

9 May 2019

RAG-1-deficient mice have no mature B and T lymphocytes

Community Assessment of Community Annotation with Ontologies

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15919

pre-B cell allelic exclusion

IMP

1 reference

14 February 2019

RAG-1 and ATM coordinate monoallelic recombination and nuclear positioning of immunoglobulin loci

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15919

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15919

IMP

chromatin organization

1 reference

9 May 2019

9 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15919

9 May 2019

The RING domain of RAG1 ubiquitylates histone H3: a novel activity in chromatin-mediated regulation of V(D)J joining

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15919

9 May 2019

Expression and V(D)J recombination activity of mutated RAG-1 proteins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15919

9 May 2019

Mutations of acidic residues in RAG1 define the active site of the V(D)J recombinase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15919

9 May 2019

RAG-1-deficient mice have no mature B and T lymphocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15919

9 May 2019

RAG-1 and RAG-2, adjacent genes that synergistically activate V(D)J recombination

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15919

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15919

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15919

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15919

Zinc finger, RING-type, conserved site

has part(s)

1 reference

RAG nonamer-binding domain

1 reference

Zinc finger, RING-type

1 reference

Zinc finger, C3HC4 RING-type

1 reference

V(D)J recombination-activating protein 1, Zinc finger

1 reference

RAG1 importin-binding

1 reference

Identifiers

1 reference

20 March 2022

1 reference

25 May 2022

1 reference

1 reference

10 August 2016

1 reference

10 August 2016

1 reference

10 August 2016

1 reference

10 August 2016