Wikidata

(Q21498923)

English

Thymoma viral proto-oncogene 1

mammalian protein found in Mus musculus

  • RAC-alpha serine/threonine-protein kinase
  • proto-oncogene c-AKT
  • Protein kinase B
  • protein kinase B-alpha
  • related to A and C kinases
  • AKT1 kinase
  • PKB alpha
  • PKB
  • RAC-PK-alpha
  • tumor rejection antigen peptide pRLib
  • Akt1m protein
  • Akt1
  • Protein kinase B alpha
  • Thymoma viral proto-oncogene
In more languages

Statements

molecular function
protein binding
determination method
IPI
23 references
retrieved
8 April 2019
stated in
KCTD20, a relative of BTBD10, is a positive regulator of Akt
GOA
curator
UniProt
UniProt protein ID
P31750
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31750
determination method
IPI
retrieved
8 April 2019
stated in
Phosphorylation of grb10 regulates its interaction with 14-3-3
GOA
curator
UniProt
UniProt protein ID
P31750
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31750
determination method
IPI
retrieved
8 April 2019
stated in
A WD-FYVE protein binds to the kinases Akt and PKCzeta/lambda
GOA
curator
UniProt
UniProt protein ID
P31750
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31750
determination method
IPI
retrieved
8 April 2019
stated in
A novel protein kinase B (PKB)/AKT-binding protein enhances PKB kinase activity and regulates DNA synthesis
GOA
curator
UniProt
UniProt protein ID
P31750
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31750
determination method
IPI
retrieved
8 April 2019
stated in
A novel Akt/PKB-interacting protein promotes cell adhesion and inhibits familial amyotrophic lateral sclerosis-linked mutant SOD1-induced neuronal death via inhibition of PP2A-mediated dephosphorylation of Akt/PKB
GOA
curator
UniProt
UniProt protein ID
P31750
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31750
determination method
IPI
retrieved
8 April 2019
stated in
Akt phosphorylates and regulates Pdcd4 tumor suppressor protein
GOA
curator
UniProt
UniProt protein ID
P31750
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31750
determination method
IPI
retrieved
8 April 2019
stated in
An Akt/beta-arrestin 2/PP2A signaling complex mediates dopaminergic neurotransmission and behavior
GOA
curator
UniProt
UniProt protein ID
P31750
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31750
determination method
IPI
retrieved
8 April 2019
stated in
ClipR-59 interacts with Akt and regulates Akt cellular compartmentalization
GOA
curator
UniProt
UniProt protein ID
P31750
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31750
determination method
IPI
retrieved
8 April 2019
stated in
ZNRF1 promotes Wallerian degeneration by degrading AKT to induce GSK3B-dependent CRMP2 phosphorylation
GOA
curator
UniProt
UniProt protein ID
P31750
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31750
determination method
IPI
retrieved
8 April 2019
stated in
BSTA promotes mTORC2-mediated phosphorylation of Akt1 to suppress expression of FoxC2 and stimulate adipocyte differentiation
GOA
curator
UniProt
UniProt protein ID
P31750
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31750
determination method
IPI
retrieved
8 April 2019
stated in
Identification and characterization of a novel gene, dapr, involved in skeletal muscle differentiation and protein kinase B signaling
GOA
curator
UniProt
UniProt protein ID
P31750
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31750
determination method
IPI
retrieved
8 April 2019
stated in
TRB3: a tribbles homolog that inhibits Akt/PKB activation by insulin in liver
GOA
curator
UniProt
UniProt protein ID
P31750
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31750
determination method
IPI
retrieved
8 April 2019
stated in
Ack1 mediated AKT/PKB tyrosine 176 phosphorylation regulates its activation
GOA
curator
UniProt
UniProt protein ID
P31750
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31750
determination method
IPI
retrieved
8 April 2019
stated in
PML regulates apoptosis at endoplasmic reticulum by modulating calcium release
GOA
curator
UniProt
UniProt protein ID
P31750
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31750
determination method
IPI
retrieved
8 April 2019
stated in
Bag1 is essential for differentiation and survival of hematopoietic and neuronal cells
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31750
determination method
IPI
retrieved
8 April 2019
stated in
Protein kinase N1, a cell inhibitor of Akt kinase, has a central role in quality control of germinal center formation
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31750
determination method
IPI
retrieved
8 April 2019
stated in
Akt augments the oncogenic potential of the HBx protein of hepatitis B virus by phosphorylation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31750
determination method
IPI
retrieved
8 April 2019
stated in
Deficiency of a beta-arrestin-2 signal complex contributes to insulin resistance.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31750
determination method
IPI
retrieved
8 April 2019
stated in
Selective activation of Akt1 by mammalian target of rapamycin complex 2 regulates cancer cell migration, invasion, and metastasis
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31750
determination method
IPI
retrieved
8 April 2019
stated in
The mammalian target of rapamycin complex 2 controls folding and stability of Akt and protein kinase C
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31750
determination method
IPI
retrieved
8 April 2019
stated in
An Akt/beta-arrestin 2/PP2A signaling complex mediates dopaminergic neurotransmission and behavior
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31750
determination method
IPI
retrieved
8 April 2019
stated in
Evidence for the involvement of FAM110C protein in cell spreading and migration
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31750
determination method
IPI
retrieved
8 April 2019
stated in
TRB3: a tribbles homolog that inhibits Akt/PKB activation by insulin in liver
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31750
determination method
IPI
protein kinase activity
determination method
IEA
IDA
7 references
retrieved
31 January 2018
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P31750&geneProductId=UniProtKB:P31750
determination method
IEA
retrieved
31 January 2018
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P31750&geneProductId=UniProtKB:P31750
determination method
IEA
retrieved
31 January 2018
stated in
Akt phosphorylates and regulates Pdcd4 tumor suppressor protein
GOA
curator
UniProt
UniProt protein ID
P31750
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P31750&geneProductId=UniProtKB:P31750
determination method
IDA
retrieved
31 January 2018
stated in
The costimulation-regulated duration of PKB activation controls T cell longevity
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P31750&geneProductId=UniProtKB:P31750
determination method
IDA
retrieved
31 January 2018
stated in
Cdc42 controls progenitor cell differentiation and beta-catenin turnover in skin
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P31750&geneProductId=UniProtKB:P31750
determination method
IDA
retrieved
31 January 2018
stated in
IL2-dependent phosphorylation of 40S ribosomal protein S6 is controlled by PI-3K/mTOR signalling in CTLL2 cells
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P31750&geneProductId=UniProtKB:P31750
determination method
IDA
retrieved
31 January 2018
stated in
PS1 activates PI3K thus inhibiting GSK-3 activity and tau overphosphorylation: effects of FAD mutations
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P31750&geneProductId=UniProtKB:P31750
determination method
IDA
protein serine/threonine kinase activity
determination method
IDA
IEA
IMP
ISO
ISS
TAS
9 references
retrieved
31 January 2018
stated in
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P31750&geneProductId=UniProtKB:P31750
determination method
TAS
retrieved
31 January 2018
stated in
GOA
curator
UniProt
UniProt protein ID
P31750
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P31750&geneProductId=UniProtKB:P31750
determination method
ISS
retrieved
31 January 2018
stated in
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P31750&geneProductId=UniProtKB:P31750
determination method
ISO
retrieved
31 January 2018
stated in
The protooncogene TCL1 is an Akt kinase coactivator
GOA
curator
UniProt
UniProt protein ID
P31750
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P31750&geneProductId=UniProtKB:P31750
determination method
IMP
retrieved
31 January 2018
stated in
GOA
curator
UniProt
UniProt protein ID
P31750
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P31750&geneProductId=UniProtKB:P31750
determination method
IEA
retrieved
31 January 2018
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P31750&geneProductId=UniProtKB:P31750
determination method
IEA
retrieved
31 January 2018
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P31750&geneProductId=UniProtKB:P31750
determination method
IEA
retrieved
31 January 2018
stated in
ZNRF1 promotes Wallerian degeneration by degrading AKT to induce GSK3B-dependent CRMP2 phosphorylation
GOA
curator
UniProt
UniProt protein ID
P31750
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P31750&geneProductId=UniProtKB:P31750
determination method
IDA
retrieved
31 January 2018
stated in
Oct4 interaction with Hmgb2 regulates Akt signaling and pluripotency
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P31750&geneProductId=UniProtKB:P31750
determination method
IDA
protein kinase activity
determination method
IDA
IEA
ISO
7 references
retrieved
8 April 2019
stated in
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31750
determination method
ISO
retrieved
8 April 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31750
determination method
IEA
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31750
determination method
IEA
retrieved
8 April 2019
stated in
Akt phosphorylates and regulates Pdcd4 tumor suppressor protein
GOA
curator
UniProt
UniProt protein ID
P31750
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31750
determination method
IDA
retrieved
8 April 2019
stated in
The costimulation-regulated duration of PKB activation controls T cell longevity
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31750
determination method
IDA
retrieved
8 April 2019
stated in
PS1 activates PI3K thus inhibiting GSK-3 activity and tau overphosphorylation: effects of FAD mutations
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31750
determination method
IDA
retrieved
8 April 2019
stated in
IL2-dependent phosphorylation of 40S ribosomal protein S6 is controlled by PI-3K/mTOR signalling in CTLL2 cells
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31750
determination method
IDA
protein serine/threonine kinase activity
determination method
IBA
IDA
IEA
IMP
ISO
ISS
TAS
10 references
retrieved
8 April 2019
stated in
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31750
determination method
TAS
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
P31750
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31750
determination method
ISS
retrieved
8 April 2019
stated in
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31750
determination method
ISO
retrieved
8 April 2019
stated in
The protooncogene TCL1 is an Akt kinase coactivator
GOA
curator
UniProt
UniProt protein ID
P31750
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31750
determination method
IMP
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
P31750
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31750
determination method
IEA
retrieved
8 April 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31750
determination method
IEA
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31750
determination method
IEA
retrieved
8 April 2019
stated in
ZNRF1 promotes Wallerian degeneration by degrading AKT to induce GSK3B-dependent CRMP2 phosphorylation
GOA
curator
UniProt
UniProt protein ID
P31750
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31750
determination method
IDA
retrieved
8 April 2019
stated in
Oct4 interaction with Hmgb2 regulates Akt signaling and pluripotency
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31750
determination method
IDA
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31750
determination method
IBA
cell component
cytoplasm
determination method
IDA
IEA
ISO
7 references
retrieved
8 April 2019
stated in
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31750
determination method
ISO
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
P31750
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31750
determination method
IEA
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31750
determination method
IEA
retrieved
8 April 2019
stated in
Akt- and Foxo1-interacting WD-repeat-FYVE protein promotes adipogenesis
GOA
curator
UniProt
UniProt protein ID
P31750
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31750
determination method
IDA
retrieved
8 April 2019
stated in
The role of Asp-462 in regulating Akt activity
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31750
determination method
IDA
retrieved
8 April 2019
stated in
Id4 deficiency attenuates prostate development and promotes PIN-like lesions by regulating androgen receptor activity and expression of NKX3.1 and PTEN
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31750
determination method
IDA
retrieved
8 April 2019
stated in
Growth arrest induces primary-cilium formation and sensitizes IGF-1-receptor signaling during differentiation induction of 3T3-L1 preadipocytes
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31750
determination method
IDA
plasma membrane
determination method
IDA
IEA
TAS
ISO
9 references
retrieved
8 April 2019
stated in
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31750
determination method
TAS
retrieved
8 April 2019
stated in
Regulation of apoptosis by the Ft1 protein, a new modulator of protein kinase B/Akt
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31750
determination method
ISO
retrieved
8 April 2019
stated in
Nonredundant role of Akt2 for neuroprotection of rod photoreceptor cells from light-induced cell death
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31750
determination method
ISO
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
P31750
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31750
determination method
IEA
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31750
determination method
IEA
retrieved
8 April 2019
stated in
Ack1 mediated AKT/PKB tyrosine 176 phosphorylation regulates its activation
GOA
curator
UniProt
UniProt protein ID
P31750
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31750
determination method
IDA
retrieved
8 April 2019
stated in
External push and internal pull forces recruit curvature-sensing N-BAR domain proteins to the plasma membrane
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31750
determination method
IDA
retrieved
8 April 2019
stated in
E-cadherin is essential for in vivo epidermal barrier function by regulating tight junctions
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31750
determination method
IDA
retrieved
8 April 2019
stated in
Phosphoinositide 3-kinase p85beta regulates invadopodium formation
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31750
determination method
IDA
biological process
protein phosphorylation
determination method
IDA
IEA
ISO
8 references
retrieved
8 April 2019
stated in
Regulation of apoptosis by the Ft1 protein, a new modulator of protein kinase B/Akt
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31750
determination method
ISO
retrieved
8 April 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31750
determination method
IEA
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31750
determination method
IEA
retrieved
8 April 2019
stated in
Ack1 mediated AKT/PKB tyrosine 176 phosphorylation regulates its activation
GOA
curator
UniProt
UniProt protein ID
P31750
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31750
determination method
IDA
retrieved
8 April 2019
stated in
Phosphorylation-dependent ubiquitylation and degradation of androgen receptor by Akt require Mdm2 E3 ligase
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31750
determination method
IDA
retrieved
8 April 2019
stated in
The costimulation-regulated duration of PKB activation controls T cell longevity
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31750
determination method
IDA
retrieved
8 April 2019
stated in
PS1 activates PI3K thus inhibiting GSK-3 activity and tau overphosphorylation: effects of FAD mutations
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31750
determination method
IDA
retrieved
8 April 2019
stated in
A role for mitogen-activated protein kinase(Erk1/2) activation and non-selective pore formation in P2X7 receptor-mediated thymocyte death
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31750
determination method
IDA

Identifiers

 
edit
    edit
      edit
        edit
          edit
            edit
              edit
                edit
                  edit
                    Retrieved from "https://www.wikidata.org/w/index.php?title=Q21498923&oldid=2023180695"