(Q22676730)

Ribosomal protein S5 domain 2-type fold

1 reference

Exoribonuclease, PH domain 2 superfamily

1 reference

PNPase/RNase PH domain superfamily

1 reference

Exoribonuclease, phosphorolytic domain 2, protein family

1 reference

based on heuristic

inferred from protein domain or family

Exoribonuclease, phosphorolytic domain 1, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

1 reference

13 November 2019

3'-5'-exoribonuclease activity

1 reference

8 April 2019

Autoantibodies directed to novel components of the PM/Scl complex, the human exosome

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06265

Reconstitution, activities, and structure of the eukaryotic RNA exosome

NAS

exoribonuclease activity

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06265

6 references

8 April 2019

A SUMO-dependent interaction between Senataxin and the exosome, disrupted in the neurodegenerative disease AOA2, targets the exosome to sites of transcription-induced DNA damage

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06265

8 April 2019

The human core exosome interacts with differentially localized processive RNases: hDIS3 and hDIS3L

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06265

8 April 2019

Histone Interaction Landscapes Visualized by Crosslinking Mass Spectrometry in Intact Cell Nuclei

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06265

8 April 2019

A human interactome in three quantitative dimensions organized by stoichiometries and abundances

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06265

8 April 2019

The association of the human PM/Scl-75 autoantigen with the exosome is dependent on a newly identified N terminus

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06265

8 April 2019

A protein interaction framework for human mRNA degradation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06265

3 references

26 September 2017

Autoantibodies directed to novel components of the PM/Scl complex, the human exosome

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q06265&geneProductId=UniProtKB:Q06265

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q06265&geneProductId=UniProtKB:Q06265

26 September 2017

Insights into RNA biology from an atlas of mammalian mRNA-binding proteins

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q06265&geneProductId=UniProtKB:Q06265

3 references

8 April 2019

Autoantibodies directed to novel components of the PM/Scl complex, the human exosome

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06265

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06265

8 April 2019

Insights into RNA biology from an atlas of mammalian mRNA-binding proteins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06265

mRNA 3'-UTR AU-rich region binding

HDA

1 reference

8 April 2019

The mammalian exosome mediates the efficient degradation of mRNAs that contain AU-rich elements

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06265

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06265

TAS

exosome (RNase complex)

nuclear exosome (RNase complex)

IDA

IEA

2 references

26 September 2017

Autoantibodies directed to novel components of the PM/Scl complex, the human exosome

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q06265&geneProductId=UniProtKB:Q06265

26 September 2017

Phosphatase of regenerating liver 2 (PRL2) is essential for placental development by down-regulating PTEN (Phosphatase and Tensin Homologue Deleted on Chromosome 10) and activating Akt protein

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q06265&geneProductId=UniProtKB:Q06265

1 reference

8 April 2019

A SUMO-dependent interaction between Senataxin and the exosome, disrupted in the neurodegenerative disease AOA2, targets the exosome to sites of transcription-induced DNA damage

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06265

4 references

8 April 2019

Molecular characterization of an autoantigen of PM-Scl in the polymyositis/scleroderma overlap syndrome: a unique and complete human cDNA encoding an apparent 75-kD acidic protein of the nucleolar complex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06265

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06265

8 April 2019

A SUMO-dependent interaction between Senataxin and the exosome, disrupted in the neurodegenerative disease AOA2, targets the exosome to sites of transcription-induced DNA damage

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06265

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06265

Proteomic analysis of exosomes from human neural stem cells by flow field-flow fractionation and nanoflow liquid chromatography-tandem mass spectrometry

IDA

extracellular exosome

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q06265&geneProductId=UniProtKB:Q06265

3 references

8 April 2019

Molecular characterization of an autoantigen of PM-Scl in the polymyositis/scleroderma overlap syndrome: a unique and complete human cDNA encoding an apparent 75-kD acidic protein of the nucleolar complex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06265

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06265

8 April 2019

Human cell growth requires a functional cytoplasmic exosome, which is involved in various mRNA decay pathways

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06265

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06265

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06265

8 April 2019

A SUMO-dependent interaction between Senataxin and the exosome, disrupted in the neurodegenerative disease AOA2, targets the exosome to sites of transcription-induced DNA damage

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06265

cytoplasmic exosome (RNase complex)

IDA

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06265

nuclear exosome (RNase complex)

3 references

8 April 2019

Autoantibodies directed to novel components of the PM/Scl complex, the human exosome

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06265

8 April 2019

Phosphatase of regenerating liver 2 (PRL2) is essential for placental development by down-regulating PTEN (Phosphatase and Tensin Homologue Deleted on Chromosome 10) and activating Akt protein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06265

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06265

Proteomic analysis of exosomes from human neural stem cells by flow field-flow fractionation and nanoflow liquid chromatography-tandem mass spectrometry

extracellular exosome

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06265

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06265

regulation of mRNA stability

IEA

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06265

nuclear polyadenylation-dependent rRNA catabolic process

TAS

1 reference

26 September 2017

Adenylation and exosome-mediated degradation of cotranscriptionally cleaved pre-messenger RNA in human cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q06265&geneProductId=UniProtKB:Q06265

nuclear-transcribed mRNA catabolic process

IMP

1 reference

8 April 2019

Human cell growth requires a functional cytoplasmic exosome, which is involved in various mRNA decay pathways

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06265

positive regulation of cell growth

IMP

1 reference

8 April 2019

Human cell growth requires a functional cytoplasmic exosome, which is involved in various mRNA decay pathways

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06265

nuclear mRNA surveillance

IMP

1 reference

26 September 2017

Human cell growth requires a functional cytoplasmic exosome, which is involved in various mRNA decay pathways

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q06265&geneProductId=UniProtKB:Q06265

1 reference

8 April 2019

Autoantibodies directed to novel components of the PM/Scl complex, the human exosome

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06265

positive regulation of transcription by RNA polymerase II

NAS

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06265

3 references

exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06265

nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5'

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06265

U1 snRNA 3'-end processing

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06265

U4 snRNA 3'-end processing

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06265

U5 snRNA 3'-end processing

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06265

nuclear polyadenylation-dependent tRNA catabolic process

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06265

nuclear polyadenylation-dependent mRNA catabolic process

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06265

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

rRNA catabolic process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06265

exonucleolytic catabolism of deadenylated mRNA

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06265

8 April 2019

The mammalian exosome mediates the efficient degradation of mRNAs that contain AU-rich elements

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06265

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06265

nuclear polyadenylation-dependent rRNA catabolic process

Exoribonuclease, phosphorolytic domain 2

1 reference

Exoribonuclease, phosphorolytic domain 1

1 reference