(Q24301865)

mRNA cis splicing, via spliceosome

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

Cwc2p YDL209C

1 reference

GOA release 2020-03-11

author

Reinhard Georg Lührmann

6

0 references

author name string

Nicolas Rasche

1

0 references

Olexandr Dybkov

2

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Jana Schmitzová

3

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Berktan Akyildiz

4

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Patrizia Fabrizio

Tertiary architecture of the Oceanobacillus iheyensis group II intron

5

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language of work or name

English

0 references

publication date

21 March 2012

0 references

published in

The EMBO Journal

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volume

31

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page(s)

1591-604

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issue

6

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cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3321175

Prp8 protein: at the heart of the spliceosome

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3321175

Characterization of U6 snRNA-protein interactions

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3321175

A general two-metal-ion mechanism for catalytic RNA

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3321175

The Prp19 WD40 Domain Contains a Conserved Protein Interaction Region Essential for Its Function

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3321175

Structure and function of an RNase H domain at the heart of the spliceosome

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3321175

Structural elucidation of a PRP8 core domain from the heart of the spliceosome

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3321175

Crystal structure of the -finger domain of Prp8 reveals analogy to ribosomal proteins

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3321175

Crystal Structure of a Self-Spliced Group II Intron

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3321175

Metal binding and base ionization in the U6 RNA intramolecular stem-loop structure

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3321175

Reconstitution of both steps of Saccharomyces cerevisiae splicing with purified spliceosomal components

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3321175

The RNA binding protein Cwc2 interacts directly with the U6 snRNA to link the nineteen complex to the spliceosome during pre-mRNA splicing

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3321175

The Isy1p component of the NineTeen complex interacts with the ATPase Prp16p to regulate the fidelity of pre-mRNA splicing

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3321175

The Prp19p-associated complex in spliceosome activation

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3321175

Characterization of interactions among the Cef1p-Prp19p-associated splicing complex

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3321175

Identification and characterization of two novel components of the Prp19p-associated complex, Ntc30p and Ntc20p

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3321175

Mechanical devices of the spliceosome: motors, clocks, springs, and things

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3321175

Spliceosome activation by PRP2 ATPase prior to the first transesterification reaction of pre-mRNA splicing

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3321175

Functional association of essential splicing factor(s) with PRP19 in a protein complex

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3321175

The tandem affinity purification (TAP) method: a general procedure of protein complex purification

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3321175

Towards understanding the catalytic core structure of the spliceosome

19 March 2017

2 references

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3321175

19 March 2017

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3321175

A stem/loop in U6 RNA defines a conformational switch required for pre-mRNA splicing

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4163966

A novel base-pairing interaction between U2 and U6 snRNAs suggests a mechanism for the catalytic activation of the spliceosome

6 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3321175

Pre-mRNA splicing: awash in a sea of proteins

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3321175

Dynamic RNA-RNA interactions in the spliceosome

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3321175

Semiquantitative proteomic analysis of the human spliceosome via a novel two-dimensional gel electrophoresis method

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3321175

Characterization of purified human Bact spliceosomal complexes reveals compositional and morphological changes during spliceosome activation and first step catalysis

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3321175

The function of the NineTeen Complex (NTC) in regulating spliceosome conformations and fidelity during pre-mRNA splicing

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3321175

The evolutionarily conserved core design of the catalytic activation step of the yeast spliceosome

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3321175

Cwc25 is a novel splicing factor required after Prp2 and Yju2 to facilitate the first catalytic reaction

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3321175

The ribozyme core of group II introns: a structure in want of partners

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3321175

A dynamic bulge in the U6 RNA internal stem-loop functions in spliceosome assembly and activation.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3321175

snRNAs as the catalysts of pre-mRNA splicing

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3321175

Insights into the mechanisms of splicing: more lessons from the ribosome

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3321175

A two-tracked approach to analyze RNA-protein crosslinking sites in native, nonlabeled small nuclear ribonucleoprotein particles

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3321175

A catalytically active group II intron domain 5 can function in the U12-dependent spliceosome

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3321175

Splicing factor slt11p and its involvement in formation of U2/U6 helix II in activation of the yeast spliceosome

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3321175

Functional analysis of the U5 snRNA loop 1 in the second catalytic step of yeast pre-mRNA splicing

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3321175

Probing the structure of RNAs in solution

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3321175

Thiophosphates in yeast U6 snRNA specifically affect pre-mRNA splicingin vitro

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3321175

Evidence that U2/U6 helix I promotes both catalytic steps of pre-mRNA splicing and rearranges in between these steps

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3321175

Multiple functions for the invariant AGC triad of U6 snRNA.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3321175

Mutations in U6 snRNA that alter splice site specificity: implications for the active site

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3321175

Two domains of yeast U6 small nuclear RNA required for both steps of nuclear precursor messenger RNA splicing

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3321175

Is the spliceosome a ribonucleoprotein enzyme?

30 May 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMBOJ.2011.502

Isolation of an active step I spliceosome and composition of its RNP core.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMBOJ.2011.502

A mechanism to enhance mRNA splicing fidelity: the RNA-dependent ATPase Prp16 governs usage of a discard pathway for aberrant lariat intermediates

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMBOJ.2011.502

The Prp19-associated complex is required for specifying interactions of U5 and U6 with pre-mRNA during spliceosome activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMBOJ.2011.502

A structural analysis of the group II intron active site and implications for the spliceosome

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMBOJ.2011.502

Repositioning of the reaction intermediate within the catalytic center of the spliceosome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMBOJ.2011.502

Splicing fidelity revisited

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMBOJ.2011.502

Proximity of conserved U6 and U2 snRNA elements to the 5' splice site region in activated spliceosomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMBOJ.2011.502

Metal-ion coordination by U6 small nuclear RNA contributes to catalysis in the spliceosome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMBOJ.2011.502

Base pairing between U2 and U6 snRNAs is necessary for splicing of a mammalian pre-mRNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMBOJ.2011.502

The U5 and U6 small nuclear RNAs as active site components of the spliceosome

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22246180

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Involvement of U6 snRNA in 5' splice site selection

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22246180

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Intrinsic metal binding by a spliceosomal RNA

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22246180

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/EMBOJ.2011.502

1 reference

1188069

1188069

1 reference

1 reference

1 reference